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The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

dc.contributor.authorChilders, Delma S.
dc.contributor.authorRaziunaite, Ingrida
dc.contributor.authorMol Avelar, Gabriela
dc.contributor.authorMackie, Joanna
dc.contributor.authorBudge, Susan
dc.contributor.authorStead, David
dc.contributor.authorGow, Neil A. R.
dc.contributor.authorLenardon, Megan D.
dc.contributor.authorBallou, Elizabeth R.
dc.contributor.authorMacCallum, Donna M.
dc.contributor.authorBrown, Alistair J. P.
dc.date.accessioned2016-04-18T09:00:06Z
dc.date.available2016-04-18T09:00:06Z
dc.date.issued2016-04-13
dc.identifier.citationChilders , D S , Raziunaite , I , Mol Avelar , G , Mackie , J , Budge , S , Stead , D , Gow , N A R , Lenardon , M D , Ballou , E R , MacCallum , D M & Brown , A J P 2016 , ' The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence ' , PLoS Pathogens , vol. 12 , no. 4 , 1005566 . https://doi.org/10.1371/journal.ppat.1005566en
dc.identifier.issn1553-7366
dc.identifier.otherPURE: 64370938
dc.identifier.otherPURE UUID: 000e6388-cd56-45c7-8ef7-2bface1ad3bc
dc.identifier.otherPubMed: 27073846
dc.identifier.otherPubMed: 27073846
dc.identifier.otherScopus: 84964811694
dc.identifier.otherORCID: /0000-0003-4833-0378/work/47631094
dc.identifier.otherORCID: /0000-0001-9268-5868/work/76974338
dc.identifier.otherORCID: /0000-0003-2869-7332/work/76975985
dc.identifier.urihttp://hdl.handle.net/2164/5870
dc.descriptionFunding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk], AJPB (BB/F00513X/1, BB/K017365/1); the CNPq-Brazil [http://cnpq.br], GMA (Science without Borders fellowship 202976/2014-9); and the National Centre for the Replacement, Refinement and Reduction of Animals in Research [www.nc3rs.org.uk], DMM (NC/K000306/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We thank Dr. Elizabeth Johnson (Mycology Reference Laboratory, Bristol) for providing strains, and the Aberdeen Proteomics facility for the biotyping of S. cerevisiae clinical isolates, and to Euroscarf for providing S. cerevisiae strains and plasmids. We are grateful to our Microscopy Facility in the Institute of Medical Sciences for their expert help with the electron microscopy, and to our friends in the Aberdeen Fungal Group for insightful discussions.en
dc.format.extent26
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.rightsCopyright: © 2016 Childers et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/en
dc.subjectQR Microbiologyen
dc.subjectWellcome Trusten
dc.subject080088en
dc.subject097377en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/F00513X/1en
dc.subjectBB/K017365/1en
dc.subjectEuropean Research Councilen
dc.subjectC-2009-AdG-249793en
dc.subjectNational Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3R's)en
dc.subjectNC/K000306/1en
dc.subjectSupplementary data availableen
dc.subject.lccQRen
dc.titleThe Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulenceen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciences (Research Theme)en
dc.contributor.institutionUniversity of Aberdeen.Clinical Medicineen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1005566
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s001en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s002en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s003en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s004en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s005en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s006en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s007en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s008en
dc.identifier.urlhttps://doi.org/10.1371/journal.ppat.1005566.s009en


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