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An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

dc.contributor.authorHay, Elizabeth Anne
dc.contributor.authorKhalaf, Abdulla Razak
dc.contributor.authorMarini, Pietro
dc.contributor.authorBrown, Andrew
dc.contributor.authorHeath, Karyn
dc.contributor.authorSheppard, Darrin
dc.contributor.authorMacKenzie, Alasdair
dc.date.accessioned2016-11-30T13:28:20Z
dc.date.available2016-11-30T13:28:20Z
dc.date.issued2017-08
dc.identifier.citationHay , E A , Khalaf , A R , Marini , P , Brown , A , Heath , K , Sheppard , D & MacKenzie , A 2017 , ' An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome ' , Neuropeptides , vol. 64 , pp. 101-107 . https://doi.org/10.1016/j.npep.2016.11.003en
dc.identifier.issn0143-4179
dc.identifier.otherPURE: 73235151
dc.identifier.otherPURE UUID: f19aae0c-77ab-493e-b412-deff773220aa
dc.identifier.otherPubMed: 27866656
dc.identifier.otherScopus: 85006804245
dc.identifier.otherORCID: /0000-0002-8456-4473/work/29354671
dc.identifier.urihttp://hdl.handle.net/2164/7773
dc.descriptionAcknowledgements These studies were funded by a Wellcome Trust (105625/Z/14/Z) ISSF starting grant, Medical Research Scotland (PhD-719-2013) and GW Pharmaceuticals (PhD-719-2013 - S.5242.001).en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofNeuropeptidesen
dc.rights© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.subjectneuropeptideen
dc.subjectenhanceren
dc.subjectCAS9/CRISPRen
dc.subjectOff-target effectsen
dc.subjecttransgenic mouseen
dc.subjectCAS9 mRNAen
dc.subjectgRNAen
dc.subject1-cell mouse embryoen
dc.subjectCytoplasmic microinjectionen
dc.subjectCRISPR design toolen
dc.subjectUCSC browser BLATen
dc.subjectPCRen
dc.subjectSanger sequencingen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject105625/Z/14/Zen
dc.subject.lccRen
dc.titleAn analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genomeen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1016/j.npep.2016.11.003
dc.identifier.vol64en


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