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Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

dc.contributor.authorHiraga, Shin-ichiro
dc.contributor.authorLy, Tony
dc.contributor.authorGarzon, Javier
dc.contributor.authorHořejší, Zuzana
dc.contributor.authorOhkubo, Yoshi-nobu
dc.contributor.authorEndo, Akinori
dc.contributor.authorObuse, Chikashi
dc.contributor.authorBoulton, Simon J.
dc.contributor.authorLamond, Angus I.
dc.contributor.authorDonaldson, Anne D.
dc.date.accessioned2017-03-02T14:28:18Z
dc.date.available2017-03-02T14:28:18Z
dc.date.issued2017-03-01
dc.identifier.citationHiraga , S , Ly , T , Garzon , J , Hořejší , Z , Ohkubo , Y , Endo , A , Obuse , C , Boulton , S J , Lamond , A I & Donaldson , A D 2017 , ' Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation ' , EMBO reports , vol. 18 , no. 3 , pp. 403-419 . https://doi.org/10.15252/embr.201641983en
dc.identifier.issn1469-221X
dc.identifier.otherPURE: 68244695
dc.identifier.otherPURE UUID: ff68c143-51fc-43eb-a870-cd1bad4e8a59
dc.identifier.otherScopus: 85010540265
dc.identifier.otherORCID: /0000-0002-8722-3869/work/29423912
dc.identifier.otherORCID: /0000-0002-5093-8385/work/46964299
dc.identifier.urihttp://hdl.handle.net/2164/8280
dc.descriptionWe thank David Stead at the Aberdeen Proteomics Service for help in mass spectrometry interpretation, and Raif Yücel and his team at the University of Aberdeen Iain Fraser Cytometry Centre for assistance with flow cytometry. We thank Robert Alver and Julian Blow at University of Dundee for advice on the use of tautomycetin. Peter Cherepanov of the Francis Crick Institute gifted XL413. Daniel Durocher of Lunenfeld-Tanenbaum Research Institute gifted DNA constructs. Work by ADD and SH was supported by Cancer Research UK Grant A13356, Cancer Research UK Programme Award A19059, and BBSRC grant (BB/K006304/1). AIL was supported by Wellcome Trust Awards (108058/Z/15/Z & 105024/Z/14/Z). This work was also supported by JSPS KAKENHI Grant # 16H04739, 25116004 to CO and 16J04327 to YO.en
dc.format.extent17
dc.language.isoeng
dc.relation.ispartofEMBO reportsen
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectRIF1en
dc.subjectPP1en
dc.subjectorigin licensingen
dc.subjectORC1en
dc.subjectMCMen
dc.subjectQH301 Biologyen
dc.subjectCancer Research UKen
dc.subjectA13356en
dc.subjectA19059en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K006304/1en
dc.subjectWellcome Trusten
dc.subject108058/Z/15/Zen
dc.subject105024/Z/14/Zen
dc.subjectSupplementary Dataen
dc.subject.lccQH301en
dc.titleHuman RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activationen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Clinical Medicineen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.15252/embr.201641983


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