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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

dc.contributor.authorYavari, Arash
dc.contributor.authorStocker, Claire J.
dc.contributor.authorGhaffari, Sahar
dc.contributor.authorWargent, Edward T.
dc.contributor.authorSteeples, Violetta
dc.contributor.authorCzibik, Gabor
dc.contributor.authorPinter, Katalin
dc.contributor.authorBellahcene, Mohamed
dc.contributor.authorWoods, Angela
dc.contributor.authorMartínez de Morentin, Pablo B.
dc.contributor.authorCansell, Céline
dc.contributor.authorLam, Brian Y. H.
dc.contributor.authorChuster, André
dc.contributor.authorPetkevicius, Kasparas
dc.contributor.authorNguyen-Tu, Marie-Sophie
dc.contributor.authorMartinez-Sanchez, Aida
dc.contributor.authorPullen, Timothy J.
dc.contributor.authorOliver, Peter L.
dc.contributor.authorStockenhuber, Alexander
dc.contributor.authorNguyen, Chinh
dc.contributor.authorLazdam, Merzaka
dc.contributor.authorO'Dowd, Jacqueline F.
dc.contributor.authorHarikumar, Parvathy
dc.contributor.authorTóth, Mónika
dc.contributor.authorBeall, Craig
dc.contributor.authorKyriakou, Theodosios
dc.contributor.authorParnis, Julia
dc.contributor.authorSarma, Dhruv
dc.contributor.authorKatritsis, George
dc.contributor.authorWortmann, Diana D. J.
dc.contributor.authorHarper, Andrew R.
dc.contributor.authorBrown, Laurence A.
dc.contributor.authorWillows, Robin
dc.contributor.authorGandra, Silvia
dc.contributor.authorPoncio, Victor
dc.contributor.authorde Oliveira Figueiredo, Márcio J.
dc.contributor.authorQi, Nathan R.
dc.contributor.authorPeirson, Stuart N.
dc.contributor.authorMcCrimmon, Rory J.
dc.contributor.authorGereben, Balázs
dc.contributor.authorTretter, László
dc.contributor.authorFekete, Csaba
dc.contributor.authorRedwood, Charles
dc.contributor.authorYeo, Giles S. H.
dc.contributor.authorHeisler, Lora K.
dc.contributor.authorRutter, Guy A.
dc.contributor.authorSmith, Mark A.
dc.contributor.authorWithers, Dominic J.
dc.contributor.authorCarling, David
dc.contributor.authorSternick, Eduardo B.
dc.contributor.authorArch, Jonathan R. S.
dc.contributor.authorCawthorne, Michael A.
dc.contributor.authorWatkins, Hugh
dc.contributor.authorAshrafian, Houman
dc.date.accessioned2017-05-18T12:00:25Z
dc.date.available2017-05-18T12:00:25Z
dc.date.issued2016-05-10
dc.identifier.citationYavari , A , Stocker , C J , Ghaffari , S , Wargent , E T , Steeples , V , Czibik , G , Pinter , K , Bellahcene , M , Woods , A , Martínez de Morentin , P B , Cansell , C , Lam , B Y H , Chuster , A , Petkevicius , K , Nguyen-Tu , M-S , Martinez-Sanchez , A , Pullen , T J , Oliver , P L , Stockenhuber , A , Nguyen , C , Lazdam , M , O'Dowd , J F , Harikumar , P , Tóth , M , Beall , C , Kyriakou , T , Parnis , J , Sarma , D , Katritsis , G , Wortmann , D D J , Harper , A R , Brown , L A , Willows , R , Gandra , S , Poncio , V , de Oliveira Figueiredo , M J , Qi , N R , Peirson , S N , McCrimmon , R J , Gereben , B , Tretter , L , Fekete , C , Redwood , C , Yeo , G S H , Heisler , L K , Rutter , G A , Smith , M A , Withers , D J , Carling , D , Sternick , E B , Arch , J R S , Cawthorne , M A , Watkins , H & Ashrafian , H 2016 , ' Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function ' , Cell Metabolism , vol. 23 , no. 5 , pp. 821-836 . https://doi.org/10.1016/j.cmet.2016.04.003en
dc.identifier.issn1550-4131
dc.identifier.otherPURE: 66682263
dc.identifier.otherPURE UUID: a8956ed7-f8c6-4d10-b982-3c182206d4cf
dc.identifier.otherPubMed: 27133129
dc.identifier.otherScopus: 84964600616
dc.identifier.urihttp://hdl.handle.net/2164/8647
dc.descriptionAcknowledgments We thank Sandra Stobrawa and colleagues (Genoway Lyon) for generating R299Q γ2 mice; families participating in the R302Q phenotyping study; Wellcome Trust Centre for Human Genetics High-Throughput Genomics Group (grant 090532/Z/09/Z) for sequencing data; Hermes Pardini for human biochemistry; Karen McGuire, Kate Thomson, and Jessica Woodley (Oxford Medical Genetics Laboratories) for R302Q genotyping; Keith Burling (Core Biochemical Assay Laboratory Cambridge) and Tertius Hough (MRC, Harwell Oxford) for murine biochemistry; Paul Trayhurn for comments; and Parisa Yavari for artwork support. This work utilized Core Services supported by grants DK089503 (MNORC) and DK020572 (MDRC) of the NIH to the University of Michigan. C.B. is supported by a Diabetes UK RD Lawrence Fellowship (13/0004647). C.F. and B.G. are supported by the Hungarian National Brain Research Program. L.K.H. is supported by the Wellcome Trust (WT098012) and BBSRC (BB/K001418/1). G.A.R. was supported by a Wellcome Trust Senior Investigator Award (WT098424AIA), MRC Programme Grant (MR/J0003042/1), and a Royal Society Wolfson Research Merit Award. A.Y. was funded by a Wellcome Trust Research Training Fellowship (086632/Z/08/Z) and is supported by the UK National Institute for Health Research. A.Y. (RE/08/004), H.W., and H.A. acknowledge support from the BHF Centre of Research Excellence, Oxford. This work was supported by a grant from the MRC to H.A. and H.W. (MR/K019023/1). This paper is dedicated to the memory of the late Professor Michael A. Cawthorne.en
dc.format.extent17
dc.language.isoeng
dc.relation.ispartofCell Metabolismen
dc.rights© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject090532/Z/09/Zen
dc.subjectWT098012en
dc.subjectWT098424AIAen
dc.subject086632/Z/08/Zen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K001418/1en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectRE/08/004en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K019023/1en
dc.subjectMR/J0003042/1en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleChronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Functionen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1016/j.cmet.2016.04.003
dc.identifier.vol23en
dc.identifier.iss5en


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