Show simple item record

An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly

dc.contributor.authorPhilippe, Lucas
dc.contributor.authorPandarakalam, George C.
dc.contributor.authorFasimoye, Rotimi
dc.contributor.authorHarrison, Neale
dc.contributor.authorConnolly, Bernadette
dc.contributor.authorPettitt, Jonathan
dc.contributor.authorMuller, Berndt
dc.date.accessioned2017-06-05T12:00:26Z
dc.date.available2017-06-05T12:00:26Z
dc.date.issued2017-08-21
dc.identifier.citationPhilippe , L , Pandarakalam , G C , Fasimoye , R , Harrison , N , Connolly , B , Pettitt , J & Muller , B 2017 , ' An in vivo genetic screen for genes involved in spliced leader trans -splicing indicates a crucial role for continuous de novo spliced leader RNP assembly ' , Nucleic Acids Research , vol. 45 , no. 14 , pp. 8474-8483 . https://doi.org/10.1093/nar/gkx500en
dc.identifier.issn0305-1048
dc.identifier.otherPURE: 101153943
dc.identifier.otherPURE UUID: 5c833370-19ee-4f43-a89f-287b19833814
dc.identifier.otherScopus: 85031849724
dc.identifier.otherORCID: /0000-0001-8195-7880/work/57461220
dc.identifier.otherORCID: /0000-0003-1279-5421/work/60546392
dc.identifier.urihttp://hdl.handle.net/2164/8751
dc.descriptionACKNOWLEDGEMENTS Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We would also like to thank Prof. Shohei Mitani,at the National Bioresource Project for the Experimental Animal ‘Nematode C. elegans’, Japan, for FX3079. We are grateful to Prof. Tom Blumenthal (University of Colorado, Boulder) for suggestions and support of this work; and to Kathrine Wood for her contribution to the initial stages of part of this work. Author contributions. L.P., G.P., R.F., N.H., J.P. and B.M. performed experiments; B.M., J.P. and B.C. designed and lead the study; B.M. and J.P. drafted the manuscript. All authors reviewed the manuscript. FUNDING Biotechnology and Biological Sciences Research Council (BBSRC) [Project grant BB/J007137/1]; Medical Research Council (MRC) Confidence in Concept 2014 - University of Aberdeen Award(MC PC 14114v.2); University of Aberdeen Elphinstone Scholarship (to R.F.) and TET Fund support through Adekunle Ajasin University, Nigeria (to R.F.). Funding for open access charge: Biotechnology and Biological Sciences Research Council and Medical Research Council.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofNucleic Acids Researchen
dc.rightsThe Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectgenesen
dc.subjectrna splicingen
dc.subjectgeneticsen
dc.subjectrnaen
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/J007137/1en
dc.subjectMedical Research Council (MRC)en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAn in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assemblyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1093/nar/gkx500
dc.identifier.vol45en
dc.identifier.iss14en


Files in this item

Thumbnail
Name:
An_in_vivo_genetic_screen_for_ ...
Size:
4.063Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record