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dc.contributor.authorvan den Berg, Marten E
dc.contributor.authorWarren, Helen R
dc.contributor.authorCabrera, Claudia P
dc.contributor.authorVerweij, Niek
dc.contributor.authorMifsud, Borbala
dc.contributor.authorHaessler, Jeffrey
dc.contributor.authorBihlmeyer, Nathan A
dc.contributor.authorFu, Yi-Ping
dc.contributor.authorWeiss, Stefan
dc.contributor.authorLin, Henry J
dc.contributor.authorGrarup, Niels
dc.contributor.authorLi-Gao, Ruifang
dc.contributor.authorPistis, Giorgio
dc.contributor.authorShah, Nabi
dc.contributor.authorBrody, Jennifer A
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorLin, Honghuang
dc.contributor.authorMei, Hao
dc.contributor.authorSmith, Albert V
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorHall, Leanne M
dc.contributor.authorvan Setten, Jessica
dc.contributor.authorTrompet, Stella
dc.contributor.authorPrins, Bram P
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorRadmanesh, Farid
dc.contributor.authorMarten, Jonathan
dc.contributor.authorEntwistle, Aiman
dc.contributor.authorKors, Jan A
dc.contributor.authorSilva, Claudia T
dc.contributor.authorAlonso, Alvaro
dc.contributor.authorBis, Joshua C
dc.contributor.authorde Boer, Rudolf
dc.contributor.authorde Haan, Hugoline G
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorDedoussis, George
dc.contributor.authorDominiczak, Anna F
dc.contributor.authorDoney, Alex S F
dc.contributor.authorEllinor, Patrick T
dc.contributor.authorEppinga, Ruben N
dc.contributor.authorFelix, Stephan B
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorHagemeijer, Yanick
dc.contributor.authorHansen, Torben
dc.contributor.authorHarris, Tamara B
dc.contributor.authorHeckbert, Susan R
dc.contributor.authorHuang, Paul L
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorKähönen, Mika
dc.contributor.authorKanters, Jørgen K
dc.contributor.authorKolcic, Ivana
dc.contributor.authorLauner, Lenore J
dc.contributor.authorLi, Man
dc.contributor.authorYao, Jie
dc.contributor.authorLinneberg, Allan
dc.contributor.authorLiu, Simin
dc.contributor.authorMacfarlane, Peter W
dc.contributor.authorMangino, Massimo
dc.contributor.authorMorris, Andrew D
dc.contributor.authorMulas, Antonella
dc.contributor.authorMurray, Alison D
dc.contributor.authorNelson, Christopher P
dc.contributor.authorOrrú, Marco
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorPeters, Annette
dc.contributor.authorPorteous, David J
dc.contributor.authorPoulter, Neil
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorQi, Lihong
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorRoselli, Carolina
dc.contributor.authorRudan, Igor
dc.contributor.authorSattar, Naveed
dc.contributor.authorSever, Peter
dc.contributor.authorSinner, Moritz F
dc.contributor.authorSoliman, Elsayed Z
dc.contributor.authorSpector, Timothy D
dc.contributor.authorStanton, Alice V
dc.contributor.authorStirrups, Kathleen E
dc.contributor.authorTaylor, Kent D
dc.contributor.authorTobin, Martin D
dc.contributor.authorUitterlinden, André
dc.contributor.authorVaartjes, Ilonca
dc.contributor.authorHoes, Arno W
dc.contributor.authorvan der Meer, Peter
dc.contributor.authorVölker, Uwe
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorXie, Zhijun
dc.contributor.authorZoledziewska, Magdalena
dc.contributor.authorTinker, Andrew
dc.contributor.authorPolasek, Ozren
dc.contributor.authorRosand, Jonathan
dc.contributor.authorJamshidi, Yalda
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorWouter Jukema, J
dc.contributor.authorAsselbergs, Folkert W
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorWilson, James
dc.contributor.authorLubitz, Steven A
dc.contributor.authorKääb, Stefan
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorCaulfield, Mark J
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorSanna, Serena
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorDeloukas, Panos
dc.contributor.authorPedersen, Oluf
dc.contributor.authorRotter, Jerome I
dc.contributor.authorDörr, Marcus
dc.contributor.authorO'Donnell, Chris J
dc.contributor.authorHayward, Caroline
dc.contributor.authorArking, Dan E
dc.contributor.authorKooperberg, Charles
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorEijgelsheim, Mark
dc.contributor.authorStricker, Bruno H
dc.contributor.authorMunroe, Patricia B
dc.date.accessioned2017-06-13T09:00:29Z
dc.date.available2017-06-13T09:00:29Z
dc.date.issued2017-06-15
dc.identifier.citationvan den Berg , M E , Warren , H R , Cabrera , C P , Verweij , N , Mifsud , B , Haessler , J , Bihlmeyer , N A , Fu , Y-P , Weiss , S , Lin , H J , Grarup , N , Li-Gao , R , Pistis , G , Shah , N , Brody , J A , Müller-Nurasyid , M , Lin , H , Mei , H , Smith , A V , Lyytikäinen , L-P , Hall , L M , van Setten , J , Trompet , S , Prins , B P , Isaacs , A , Radmanesh , F , Marten , J , Entwistle , A , Kors , J A , Silva , C T , Alonso , A , Bis , J C , de Boer , R , de Haan , H G , de Mutsert , R , Dedoussis , G , Dominiczak , A F , Doney , A S F , Ellinor , P T , Eppinga , R N , Felix , S B , Guo , X , Hagemeijer , Y , Hansen , T , Harris , T B , Heckbert , S R , Huang , P L , Hwang , S-J , Kähönen , M , Kanters , J K , Kolcic , I , Launer , L J , Li , M , Yao , J , Linneberg , A , Liu , S , Macfarlane , P W , Mangino , M , Morris , A D , Mulas , A , Murray , A D , Nelson , C P , Orrú , M , Padmanabhan , S , Peters , A , Porteous , D J , Poulter , N , Psaty , B M , Qi , L , Raitakari , O T , Rivadeneira , F , Roselli , C , Rudan , I , Sattar , N , Sever , P , Sinner , M F , Soliman , E Z , Spector , T D , Stanton , A V , Stirrups , K E , Taylor , K D , Tobin , M D , Uitterlinden , A , Vaartjes , I , Hoes , A W , van der Meer , P , Völker , U , Waldenberger , M , Xie , Z , Zoledziewska , M , Tinker , A , Polasek , O , Rosand , J , Jamshidi , Y , van Duijn , C M , Zeggini , E , Wouter Jukema , J , Asselbergs , F W , Samani , N J , Lehtimäki , T , Gudnason , V , Wilson , J , Lubitz , S A , Kääb , S , Sotoodehnia , N , Caulfield , M J , Palmer , C N A , Sanna , S , Mook-Kanamori , D O , Deloukas , P , Pedersen , O , Rotter , J I , Dörr , M , O'Donnell , C J , Hayward , C , Arking , D E , Kooperberg , C , van der Harst , P , Eijgelsheim , M , Stricker , B H & Munroe , P B 2017 , ' Discovery of novel heart rate-associated loci using the Exome Chip ' , Human Molecular Genetics , vol. 26 , no. 12 , pp. 2346-2363 . https://doi.org/10.1093/hmg/ddx113en
dc.identifier.issn0964-6906
dc.identifier.otherPURE: 100542868
dc.identifier.otherPURE UUID: 468b78a7-1256-446e-aef2-91f0024f9116
dc.identifier.otherPubMed: 28379579
dc.identifier.otherScopus: 85031038119
dc.identifier.otherORCID: /0000-0003-4915-4847/work/44018578
dc.identifier.urihttp://hdl.handle.net/2164/8801
dc.descriptionIndividual studies 1958BC: We are grateful for using the British 1958 Birth Cohort DNA collection. ARIC: The authors thank the staff and participants of the ARIC study for their important contributions. ASCOT: We thank all ASCOT trial participants, physicians, nurses, and practices in the participating countries for their important contribution to the study. In particular we thank Clare Muckian and David Toomey for their help in DNA extraction, storage and handling. We would also like to acknowledge the Barts and The London Genome Centre staff for genotyping the Exome Chip array. BRIGHT: The BRIGHT study is extremely grateful to all the patients who participated in the study and the BRIGHT nursing team. CROATIA-Korcula: We would like to acknowledge the contributions of the recruitment team in Korcula, the administrative teams in Croatia and Edinburgh and the people of Korcula. Exome array genotyping was performed at the Wellcome Trust Clinical Research Facility Genetics Core at Western General Hospital, Edinburgh, UK. ERF: We are grateful to all study participants and their relatives, general practitioners and neurologists for their contributions to the ERF study and to P. Veraart for her help in genealogy, J. Vergeer for the supervision of the laboratory work and P. Snijders for his help in data collection. GoDARTs: We are grateful to all the participants in this study, the general practitioners, the Scottish School of Primary Care for their help in recruiting the participants, and to the whole team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. The study complies with the Declaration of Helsinki. We acknowledge the support of the Health Informatics Centre, University of Dundee for managing and supplying the anonymized data and NHS Tayside, the original data owner. GRAPHIC: This work falls under the portfolio of research supported by the NIHR Leicester Cardiovascular Biomedical Research Unit. GS:SFHS: We are grateful to all the families who took part, the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the whole Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants and nurses. Ethics approval for the study was given by the NHS Tayside committee on research ethics (reference 05/S1401/89). HELIC: The MANOLIS cohort is named in honour of Manolis Giannakakis, 1978–2010. We thank the residents of the Mylopotamos villages, and of the Pomak villages, for taking part. The HELIC study has been supported by many individuals who have contributed to sample collection (including Antonis Athanasiadis, Olina Balafouti, Christina Batzaki, Georgios Daskalakis, Eleni Emmanouil, Chrisoula Giannakaki, Margarita Giannakopoulou, Anastasia Kaparou, Vasiliki Kariakli, Stella Koinaki, Dimitra Kokori, Maria Konidari, Hara Koundouraki, Dimitris Koutoukidis, Vasiliki Mamakou, Eirini Mamalaki, Eirini Mpamiaki, Maria Tsoukana, Dimitra Tzakou, Katerina Vosdogianni, Niovi Xenaki, Eleni Zengini), data entry (Thanos Antonos, Dimitra Papagrigoriou, Betty Spiliopoulou), sample logistics (Sarah Edkins, Emma Gray), genotyping (Robert Andrews, Hannah Blackburn, Doug Simpkin, Siobhan Whitehead), research administration (Anja Kolb-Kokocinski, Carol Smee, Danielle Walker) and informatics (Martin Pollard, Josh Randall). JHS: We thank the Jackson Heart Study (JHS) participants and staff for their contributions to this work. The JHS is supported by contracts HHSN268201300046C, HHSN268201300047C, HHSN 268201300048C, HHSN268201300049C, HHSN268201300050C from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities. KORA: We thank all KORA participants and staff members as well as Nadine Lindemann and Franziska Scharl involved in the generation of the SNP data. Lifelines: We thank U. Bultmann (1), J.M. Geleijnse (2), P. van der Harst (3), S. Mulder (4), J.G.M. Rosmalen (5), E.F.C. van Rossum (6), H.A. Smit (7), M. Swertz (8), E.A.L.M. Verhagen (9) (1) Department of Social Medicine, University Medical Center Groningen, University of Groningen, The Netherlands, (2) Department of Human Nutrition, Wageningen University, The Netherlands, (3) Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands, (4) Lifelines Cohort Study, The Netherlands, (5) Interdisciplinary Center of Psychopathology of Emotion Regulation (ICPE), Department of Psychiatry, University Medical Center Groningen, University of Groningen, The Netherlands, (6) Department of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands, (7) Department of Public Health, University Medical Center Utrecht, The Netherlands, (8) Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands, (9) Department of Public and Occupational Health, VU Medical Center, Amsterdam, The Netherlands. NEO: The authors of the NEO study thank all individuals who participated in the Netherlands Epidemiology in Obesity study, all participating general practitioners for inviting eligible participants and all research nurses for collection of the data. We thank the NEO study group, Pat van Beelen, Petra Noordijk and Ingeborg de Jonge for the coordination, lab and data management of the NEO study. The genotyping in the NEO study was supported by the Centre National de Génotypage (Paris, France), headed by Jean-Francois Deleuze. RS: The generation and management of the Illumina Exome Chip v1.0 array data for the Rotterdam Study (RS-I) was executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. The authors are grateful to the study participants, the staff from the Rotterdam Study and the participating general practitioners and pharmacists. We thank Ms Mila Jhamai, Ms Sarah Higgins and Mr Marijn Verkerk for their help in creating the Exome Chip database, and Carolina Medina-Gomez, MSc, Lennard Karsten, MSc and Linda Broer PhD for QC and variant calling. Variants were called using the best practice protocol developed by Grove et al. as part of the CHARGE consortium Exome Chip central calling effort SardiNIA: We thank all the volunteers who generously participated in this study and made this research possible. SHIP: We thank all SHIP and SHIP-TREND participants and staff members as well as the genotyping staff involved in the generation of the SNP data. WHI: The authors thank the WHI investigators and staff for their dedication, and the study participants for making the program possible. A full listing of WHI investigators can be found at: http://www.whi.org/researchers/Documents%20%20Write% 20a%20Paper/WHI%20Investigator%20Long%20List.pdf YFS: The expert technical assistance in the statistical analyses by Irina Lisinen is gratefully acknowledged. UK Biobank: This research has been conducted using the UK Biobank Resource Application Number 9628. Conflicts of Interest statement. Dr B.M.P. serves on the DSMB of a clinical trial funded by the manufacturer (Zoll LifeCor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. Dr P.T.E. is the PI on a grant from Bayer HealthCare to the Broad Institute focused on the genetics and therapeutics of atrial fibrillation. Dr N.P. has received financial support from several pharmaceutical companies that manufacture either blood pressure lowering or lipid lowering agents or both and consultancy fees. Dr P.S. has received research awards from Pfizer. Dr M.J.C. is Chief Scientist for Genomics England, a UK government company.en
dc.format.extent18
dc.language.isoeng
dc.relation.ispartofHuman Molecular Geneticsen
dc.rightsCopyright The Author 2017. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectJournal Articleen
dc.subjectheart rateen
dc.subjectlungen
dc.subjectchromatinen
dc.subjectfollow-upen
dc.subjectgenesen
dc.subjectgeneticsen
dc.subjecthearten
dc.subjectcandidate disease geneen
dc.subjectgenome-wide association studyen
dc.subjectexomeen
dc.subjectbiobanksen
dc.subjectdatasetsen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L016311/1.en
dc.subjectMR/N025083/1.en
dc.subjectBritish Heart Foundationen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subject.lccRen
dc.titleDiscovery of novel heart rate-associated loci using the Exome Chipen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Data Safe Havenen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Clinical Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1093/hmg/ddx113


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