This is the peer reviewed version of the following article: Druce, K. L., Jones, G. T., Macfarlane, G. J. and Basu, N. (2016), Examining Changes in Central and Peripheral Pain as Mediates of Fatigue Improvement: Results From the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Arthritis Care & Research, 68: 922–926., which has been published in final form at DOI: 10.1002/acr.22803. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.