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Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis

dc.contributor.authorThompson, Dawn
dc.contributor.authorMorrice, Nicola
dc.contributor.authorGrant, Louise
dc.contributor.authorLe Sommer, Samantha
dc.contributor.authorLees, Emma K
dc.contributor.authorMody, Nimesh
dc.contributor.authorWilson, Heather M
dc.contributor.authorDelibegovic, Mirela
dc.date.accessioned2017-09-29T09:00:12Z
dc.date.available2017-09-29T09:00:12Z
dc.date.issued2017-10-01
dc.identifier.citationThompson , D , Morrice , N , Grant , L , Le Sommer , S , Lees , E K , Mody , N , Wilson , H M & Delibegovic , M 2017 , ' Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis ' , Clinical Science , vol. 131 , no. 20 , pp. 2489-2501 . https://doi.org/10.1042/CS20171066en
dc.identifier.issn0143-5221
dc.identifier.otherPURE: 107822984
dc.identifier.otherPURE UUID: e9dc3ac0-47a1-4f02-bcec-66716c56a8be
dc.identifier.otherScopus: 85031014506
dc.identifier.otherORCID: /0000-0003-3301-7397/work/60546621
dc.identifier.otherORCID: /0000-0002-2215-7952/work/36967463
dc.identifier.otherORCID: /0000-0003-0948-9458/work/77366287
dc.identifier.otherORCID: /0000-0002-1407-7274/work/83704340
dc.identifier.urihttp://hdl.handle.net/2164/9373
dc.descriptionThe authors wish to thank Professor Nicholas Tonks for providing the PTP1B inhibitor trodusquemine; Linda Robertson for her help with the aorta histology; Dr Fiona Grieg for tuition into aortic dissection and Dr James Hislop for critical reading of this manuscript. We also wish to thank the British Heart Foundation (PG/14/43/30889) for supporting this researchen
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofClinical Scienceen
dc.rights© 2017 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectprotein tyrosine phosphatasesen
dc.subjectmetabolic syndromesen
dc.subjectatherosclerosisen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectPG/14/43/30889en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titlePharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1042/CS20171066
dc.identifier.vol131en
dc.identifier.iss20en


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