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Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

dc.contributor.authorZeng, Yanni
dc.contributor.authorNavarro, Pau
dc.contributor.authorShirali, Masoud
dc.contributor.authorHoward, David M.
dc.contributor.authorAdams, Mark J.
dc.contributor.authorHall, Lynsey S.
dc.contributor.authorClarke, Toni Kim
dc.contributor.authorThomson, Pippa A.
dc.contributor.authorSmith, Blair H.
dc.contributor.authorMurray, Alison
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorHayward, Caroline
dc.contributor.authorBoutin, Thibaud
dc.contributor.authorMacIntyre, Donald J.
dc.contributor.authorLewis, Cathryn M.
dc.contributor.authorWray, Naomi R.
dc.contributor.authorMehta, Divya
dc.contributor.authorPenninx, Brenda W.J.H.
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorAir, Tracy
dc.contributor.authorHottenga, Jouke Jan
dc.contributor.authorMbarek, Hamdi
dc.contributor.authorCastelao, Enrique
dc.contributor.authorPistis, Giorgio
dc.contributor.authorSchulze, Thomas G.
dc.contributor.authorStreit, Fabian
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorByrne, Enda M.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorBreen, Gerome
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorLucae, Susanne
dc.contributor.authorKloiber, Stefan
dc.contributor.authorDomenici, Enrico
dc.contributor.authorDeary, Ian J.
dc.contributor.authorPorteous, David J.
dc.contributor.authorHaley, Chris S.
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium
dc.date.accessioned2017-12-21T00:03:12Z
dc.date.available2017-12-21T00:03:12Z
dc.date.issued2017-09-01
dc.identifier.citationZeng , Y , Navarro , P , Shirali , M , Howard , D M , Adams , M J , Hall , L S , Clarke , T K , Thomson , P A , Smith , B H , Murray , A , Padmanabhan , S , Hayward , C , Boutin , T , MacIntyre , D J , Lewis , C M , Wray , N R , Mehta , D , Penninx , B W J H , Milaneschi , Y , Baune , B T , Air , T , Hottenga , J J , Mbarek , H , Castelao , E , Pistis , G , Schulze , T G , Streit , F , Forstner , A J , Byrne , E M , Martin , N G , Breen , G , Müller-Myhsok , B , Lucae , S , Kloiber , S , Domenici , E , Deary , I J , Porteous , D J , Haley , C S , McIntosh , A M & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2017 , ' Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder ' , Biological Psychiatry , vol. 82 , no. 5 , pp. 312-321 . https://doi.org/10.1016/j.biopsych.2016.12.012en
dc.identifier.issn0006-3223
dc.identifier.otherPURE: 113400722
dc.identifier.otherPURE UUID: aa07d230-a9ad-4e94-a627-65a92fecace1
dc.identifier.otherScopus: 85010952799
dc.identifier.otherPubMed: 28153336
dc.identifier.otherORCID: /0000-0003-4915-4847/work/44018546
dc.identifier.urihttp://hdl.handle.net/2164/9809
dc.descriptionAcknowledgments and Disclosures: This work was supported by the Wellcome Trust through a Strategic Award (104036/Z/14/Z). The Chief Scientist Office of the Scottish Government and the Scottish Funding Council provided core support for Generation Scotland. GS:SFHS was funded by a grant from the Scottish Government Health Department, Chief Scientist Office (CZD/16/6). We are grateful to the families who took part in GS:SFHS, the general practitioners and Scottish School of Primary Care for their help in recruiting them, and the whole Generation Scotland team, which includes academic researchers, clinic staff members, laboratory technicians, clerical workers, information technology staff members, statisticians, and research managers. AMM has previously received grant support from Pfizer, Lilly, and Janssen. These studies are not connected to the current investigation. YZ acknowledges support from the China Scholarship Council. T-KC and AMM acknowledge with gratitude the financial support received for this work from the Dr Mortimer and Theresa Sackler Foundation. PAT, DJP, IJD, and AMM are members of the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross-council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the Biotechnology and Biological Sciences Research Council and Medical Research Council (MRC) is gratefully acknowledged. DJM is an NHS Research Scotland (NRS) Fellow, funded by the Chief Scientist Office. PN and CSH acknowledge support from the MRC. All other authors report no biomedical financial interests or potential conflicts of interest. GS:SFHS data are available to researchers on application to the Generation Scotland Access Committee (access: http://generationscotland.org). The managed access process ensures that approval is granted only to research that comes under the terms of participant consent.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofBiological Psychiatryen
dc.rights© 2017 Society of Biological Psychiatry. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectGenome-wide analysesen
dc.subjectHaplotype blocken
dc.subjectHRHMen
dc.subjectMDDen
dc.subjectRegional heritabilityen
dc.subjectTOX2en
dc.subjectR Medicineen
dc.subjectBiological Psychiatryen
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subject.lccRen
dc.titleGenome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorderen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.1016/j.biopsych.2016.12.012
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85010952799&partnerID=8YFLogxKen
dc.identifier.vol82en
dc.identifier.iss5en


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