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A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

dc.contributor.authorSchwab, Karima
dc.contributor.authorFrahm, Silke
dc.contributor.authorHorsley, David
dc.contributor.authorRickard, Janet E
dc.contributor.authorMelis, Valeria
dc.contributor.authorGoatman, Elizabeth A
dc.contributor.authorMagbagbeolu, Mandy
dc.contributor.authorDouglas, Morag
dc.contributor.authorLeith, Michael G
dc.contributor.authorBaddeley, Thomas C.
dc.contributor.authorStorey, John M D
dc.contributor.authorRiedel, Gernot
dc.contributor.authorWischik, Claude M
dc.contributor.authorHarrington, Charles R
dc.contributor.authorTheuring, Franz
dc.date.accessioned2018-02-01T13:10:08Z
dc.date.available2018-02-01T13:10:08Z
dc.date.issued2018-01-10
dc.identifier.citationSchwab , K , Frahm , S , Horsley , D , Rickard , J E , Melis , V , Goatman , E A , Magbagbeolu , M , Douglas , M , Leith , M G , Baddeley , T C , Storey , J M D , Riedel , G , Wischik , C M , Harrington , C R & Theuring , F 2018 , ' A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy ' , Frontiers in Molecular Neuroscience , vol. 10 , 447 . https://doi.org/10.3389/fnmol.2017.00447en
dc.identifier.issn1662-5099
dc.identifier.otherPURE: 115416241
dc.identifier.otherPURE UUID: b0597bf5-33b0-4874-82ed-b0faf565b61b
dc.identifier.otherPubMed: 29375308
dc.identifier.otherPubMedCentral: PMC5767730
dc.identifier.otherScopus: 85041335338
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579148
dc.identifier.otherORCID: /0000-0001-7063-7136/work/96652493
dc.identifier.urihttp://hdl.handle.net/2164/9976
dc.descriptionThe authors acknowledge Heide Lueck for excellent technical assistance and for maintenance of animals. AMS Biotechnology generated monoclonal antibodies from recombinant α-Syn prepared by JR.en
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofFrontiers in Molecular Neuroscienceen
dc.rightsCopyright © 2018 Schwab, Frahm, Horsley, Rickard, Melis, Goatman, Magbagbeolu, Douglas, Leith, Baddeley, Storey, Riedel, Wischik, Harrington and Theuring. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/4.0/en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectaggregation inhibitoren
dc.subjectsynucleinopathyen
dc.subjectleucomethylthioniniumen
dc.subjectmouse modelen
dc.subjectParkinson’s diseaseen
dc.subjectα-Synucleinen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.description.statusPeer revieweden
dc.description.versionPublisher PDFen
dc.identifier.doihttps://doi.org/10.3389/fnmol.2017.00447
dc.identifier.vol10en


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