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Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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dc.contributor.authorHoward, David M.
dc.contributor.authorHall, Lynsey S
dc.contributor.authorHafferty, Jonathan D.
dc.contributor.authorZeng, Yanni
dc.contributor.authorAdams, Mark James
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorPorteous, David J.
dc.contributor.authorNagy, Reka
dc.contributor.authorHayward, Caroline
dc.contributor.authorSmith, Blair H.
dc.contributor.authorMurray, Alison D.
dc.contributor.authorRyan, Niamh M.
dc.contributor.authorEvans, Kathryn L.
dc.contributor.authorHaley, Chris S.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorThomson, Pippa A.
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2017-12-13T10:12:05Z
dc.date.available2017-12-13T10:12:05Z
dc.date.issued2017
dc.descriptionGeneration Scotland received core funding from the Chief Scientist Office of the Scottish Government Health Directorate CZD/16/6 and the Scottish Funding Council HR03006. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL) Reference 104036/Z/14/Z. YZ acknowledges support from China Scholarship Council. IJD is supported by the Centre for Cognitive Ageing and Cognitive Epidemiology which is funded by the Medical Research Council and the Biotechnology and Biological Sciences Research Council (MR/K026992/1). AMMcI and T-KC acknowledges support from the Dr Mortimer and Theresa Sackler Foundation. We are grateful to all the families who took part, the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the whole Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants and nurses. Ethics approval for the study was given by the NHS Tayside committee on research ethics (reference 05/S1401/8)en
dc.description.statusPeer revieweden
dc.format.extent1170212
dc.identifier105630390
dc.identifier0892ac64-e165-45c6-a49e-91305465dcc9
dc.identifier85036531560
dc.identifier.citationHoward, D M, Hall, L S, Hafferty, J D, Zeng, Y, Adams, M J, Clarke, T-K, Porteous, D J, Nagy, R, Hayward, C, Smith, B H, Murray, A D, Ryan, N M, Evans, K L, Haley, C S, Deary, I J, Thomson, P A & McIntosh, A M 2017, 'Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank', Translational Psychiatry, vol. 7, 1263. https://doi.org/10.1038/s41398-017-0010-9en
dc.identifier.doi10.1038/s41398-017-0010-9
dc.identifier.issn2158-3188
dc.identifier.otherORCID: /0000-0003-4915-4847/work/44018519
dc.identifier.urihttp://hdl.handle.net/2164/9774
dc.identifier.vol7en
dc.language.isoeng
dc.relation.ispartofTranslational Psychiatryen
dc.subjecthaplotype association analysisen
dc.subjectcognitionen
dc.subjectintelligenceen
dc.subjectIQ Generation Scotlanden
dc.subjectUK Biobanken
dc.subjectEnglish Longitudinal Study of Agingen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K026992/1en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subject.lccRC0321en
dc.titleGenome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobanken
dc.typeJournal articleen

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