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Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

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dc.contributor.authorAl-Hilaly, Youssra K.
dc.contributor.authorPollack, Saskia J.
dc.contributor.authorRickard, Janet E.
dc.contributor.authorSimpson, Michael
dc.contributor.authorRaulin, Ana-C
dc.contributor.authorBaddeley, Thomas
dc.contributor.authorSchellenberger, Pascale
dc.contributor.authorStorey, John M. D.
dc.contributor.authorHarrington, Charles R.
dc.contributor.authorWischik, Claude M.
dc.contributor.authorSerpell, Louise C.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2018-10-12T14:00:07Z
dc.date.available2018-10-12T14:00:07Z
dc.date.issued2018-10-19
dc.descriptionTEM work was performed at the School of Life Sciences TEM Imaging Centre at the University of Sussex, which is supported by the Wellcome Trust and RM Phillips. SP and AR are supported by a Sussex Neuroscience doctoral training centre. LCS is supported by Alzheimer's Society and Alzheimer's Research UK Southcoast Network. YA, JR, TB and MS are supported by TauRx Therapeutics Ltd. and CH, JS and CW serve as officers in TauRx Therapeutics Ltd.en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent2396281
dc.identifier131367224
dc.identifier7347ac83-315c-4c76-896c-529fcfeb7a17
dc.identifier30121297
dc.identifier85053053674
dc.identifier000448493400017
dc.identifier.citationAl-Hilaly, Y K, Pollack, S J, Rickard, J E, Simpson, M, Raulin, A-C, Baddeley, T, Schellenberger, P, Storey, J M D, Harrington, C R, Wischik, C M & Serpell, L C 2018, 'Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)', Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131. https://doi.org/10.1016/j.jmb.2018.08.010en
dc.identifier.doi10.1016/j.jmb.2018.08.010
dc.identifier.iss21en
dc.identifier.issn0022-2836
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579165
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415892
dc.identifier.urihttp://hdl.handle.net/2164/11249
dc.identifier.vol430en
dc.language.isoeng
dc.relation.ispartofJournal of Molecular Biologyen
dc.subjectTauen
dc.subjectMethylthioniniumen
dc.subjectHydromethylthionineen
dc.subjectNeurofibrillary tanglesen
dc.subjectCircular dichroismen
dc.subjectElectron microscopyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectQD Chemistryen
dc.subjectAlzheimers Research UKen
dc.subject.lccRC0321en
dc.subject.lccQDen
dc.titleCysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)en
dc.typeJournal articleen

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