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Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents

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dc.contributor.authorBuschhaus, Magdalena J
dc.contributor.authorBecker, Stefan
dc.contributor.authorPorter, Andrew J
dc.contributor.authorBarelle, Caroline J
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2021-03-02T00:20:34Z
dc.date.available2021-03-02T00:20:34Z
dc.date.embargoedUntil2021-03-02
dc.date.issued2020-09
dc.descriptionFunding This work was supported by the Industrial Biotechnology Innovation Centre, and Merck KGaA. Acknowledgements The authors would like to thank Iris Willenbücher and Kerstin Hallstein for the BIAcore™ analysis and Nadine Barron for the bio-layer interferometry work.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent1064309
dc.identifier158360204
dc.identifier8db74b7b-d163-4dea-9166-794c848f48a9
dc.identifier32119084
dc.identifier000536506800001
dc.identifier85082561719
dc.identifier.citationBuschhaus, M J, Becker, S, Porter, A J & Barelle, C J 2020, 'Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents', Protein engineering, design & selection : PEDS, vol. 32, no. 9, pp. 385-399. https://doi.org/10.1093/protein/gzaa002en
dc.identifier.doi10.1093/protein/gzaa002
dc.identifier.iss9en
dc.identifier.issn1741-0126
dc.identifier.urihttps://hdl.handle.net/2164/15951
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85082561719&partnerID=8YFLogxKen
dc.identifier.vol32en
dc.language.isoeng
dc.relation.ispartofProtein engineering, design & selection : PEDSen
dc.subjectaffinity liganden
dc.subjectphage displayen
dc.subjectSEED bispecific antibody platformen
dc.subjectshark IgNARen
dc.subjectvariable new antigen receptoren
dc.subjectBISPECIFIC ANTIBODIESen
dc.subjectCOMPLEXen
dc.subjectIMMUNOGLOBULINen
dc.subjectANTIBODY FRAGMENTSen
dc.subjectANTIGEN RECEPTOR IGNARen
dc.subjectPLATFORMen
dc.subjectAFFINITY LIGANDSen
dc.subjectSHARKen
dc.subjectSEEDen
dc.subjectPURIFICATIONen
dc.subjectR Medicineen
dc.subjectBioengineeringen
dc.subjectMolecular Biologyen
dc.subjectBiochemistryen
dc.subjectBiotechnologyen
dc.subject.lccRen
dc.titleIsolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagentsen
dc.typeJournal articleen

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