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Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease

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dc.contributor.authorMcCartney, Daniel L
dc.contributor.authorStevenson, Anna J
dc.contributor.authorWalker, Rosie M
dc.contributor.authorGibson, Jude
dc.contributor.authorMorris, Stewart W
dc.contributor.authorCampbell, Archie
dc.contributor.authorMurray, Alison D
dc.contributor.authorWhalley, Heather C
dc.contributor.authorPorteous, David J
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorEvans, Kathryn L
dc.contributor.authorDeary, Ian J
dc.contributor.authorMarioni, Riccardo E
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2018-10-03T13:50:10Z
dc.date.available2018-10-03T13:50:10Z
dc.date.issued2018
dc.descriptionThis work was supported by a Alzheimer's Research UK Major Project grant (ARUK-PG2017B-10). Generation Scotland received core funding from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). We are grateful to all the families who took part, the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the whole Generation Scotland team that includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, health-care assistants and nurses. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” [STRADL];104036/Z/14/Z). DNA methylation data collection was funded by the Wellcome Trust Strategic Award (10436/Z/14/Z). The research was conducted in the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), part of the cross-council Lifelong Health and Wellbeing Initiative (MR/K026992/1); funding from the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) is gratefully acknowledged. CCACE supports I.J.D. with some additional support from the Dementias Platform UK (MR/L015382/1). A.M.M. and H.C.W. have received support from the Sackler Institute.en
dc.description.statusPeer revieweden
dc.format.extent9
dc.format.extent522525
dc.identifier139598209
dc.identifier85d43261-c079-4fd3-9313-4f9e8aa5a5cf
dc.identifier30167451
dc.identifier85052088393
dc.identifier.citationMcCartney, D L, Stevenson, A J, Walker, R M, Gibson, J, Morris, S W, Campbell, A, Murray, A D, Whalley, H C, Porteous, D J, McIntosh, A M, Evans, K L, Deary, I J & Marioni, R E 2018, 'Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 10, pp. 429-437. https://doi.org/10.1016/j.dadm.2018.05.006en
dc.identifier.doi10.1016/j.dadm.2018.05.006
dc.identifier.issn2352-8729
dc.identifier.otherPubMedCentral: PMC6111045
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976580
dc.identifier.urihttp://hdl.handle.net/2164/11211
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringen
dc.subjectDNA METHYLATIONen
dc.subjectEpigenetic clocken
dc.subjectAlzheimer's diseaseen
dc.subjectgeneticsen
dc.subjectGeneration Scotlanden
dc.subjectR Medicineen
dc.subjectAlzheimers Research UKen
dc.subjectARUK-PG2017B-10en
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K026992/1en
dc.subjectMR/L015382/1en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subject.lccRen
dc.titleInvestigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's diseaseen
dc.typeJournal articleen

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