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Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes

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dc.contributor.authorMezincescu, Alice-Mihaela
dc.contributor.authorRudd, Amelia Elizabeth
dc.contributor.authorCheyne, Lesley
dc.contributor.authorHorgan, Graham
dc.contributor.authorPhilip, Sam
dc.contributor.authorCameron, Donnie
dc.contributor.authorvan Loon, Luc
dc.contributor.authorWhitefield, Phil
dc.contributor.authorGribbin, Rachael
dc.contributor.authorHu, May Khei
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorFielding, Barbara
dc.contributor.authorLobley, Gerald
dc.contributor.authorThies, Frank
dc.contributor.authorNewby, David E
dc.contributor.authorGray, Stuart
dc.contributor.authorHenning, Anke
dc.contributor.authorDawson, Dana
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Health Data Scienceen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2024-06-13T15:11:04Z
dc.date.available2024-06-13T15:11:04Z
dc.date.issued2024-12
dc.descriptionContributions D.D., A.H., S.G., S.P. and M.D. conceived the study and together with L.v.L., G.L., F.T. obtained the grant funding. AM executed the patient screening, recruitment, intervention planning, carried out all study investigations under respective specialist supervision (A.H./D.C./D.D. for magnetic resonance spectroscopy, F.T./G.L./D.D. for stable isotope investigation, S.G. for exercise intervention, S.P. for clinical supervision/management of diabetes as required, M.D. for all molecular laboratory analyses, A.M. analysed all data and performed statistical analysis under the supervision of G.H. L.v.L. provided expert advice in athletic physiology. Lipidomic analyses were carried out in P.W. laboratory. Blood/skeletal muscle enrichment analyses were carried out in B.F./F.T.-G.L. laboratories respectively, with practical input from R.G. A.R. and L.C. contributed as overall help to deliver study assessments in a technical role. M.K.H. analysed the food diaries. D.E.N. contributed to manuscript writing. D.D. and M.D. were the PhD supervisors for A.M. whose PhD thesis was based on this work. All authors contributed their respective specialist sections in drafting the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent1357253
dc.identifier288706760
dc.identifier32def9dd-91e5-4a39-8c0d-7bbdc7cc4c91
dc.identifier38750012
dc.identifier85193313580
dc.identifier.citationMezincescu, A-M, Rudd, A E, Cheyne, L, Horgan, G, Philip, S, Cameron, D, van Loon, L, Whitefield, P, Gribbin, R, Hu, M K, Delibegovic, M, Fielding, B, Lobley, G, Thies, F, Newby, D E, Gray, S, Henning, A & Dawson, D 2024, 'Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes', Nature Communications, vol. 15, no. 1, 3690, pp. 3690. https://doi.org/10.1038/s41467-024-47843-y, https://doi.org/10.6084/m9.figshare.24219934en
dc.identifier.doi10.1038/s41467-024-47843-y
dc.identifier.iss1en
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0001-6164-211X/work/174357574
dc.identifier.otherORCID: /0000-0003-2815-4469/work/174357670
dc.identifier.otherORCID: /0000-0001-6193-3152/work/174358051
dc.identifier.otherORCID: /0000-0002-9275-9713/work/174358645
dc.identifier.otherORCID: /0000-0002-6048-1374/work/181760130
dc.identifier.urihttps://hdl.handle.net/2164/23599
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85193313580&partnerID=8YFLogxKen
dc.identifier.urlhttps://abdn.elsevierpure.com/en/publications/32def9dd-91e5-4a39-8c0d-7bbdc7cc4c91en
dc.identifier.vol15en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectAthletesen
dc.subjectLipid Metabolismen
dc.subjectDiabetes Mellitus, Type 2/metabolismen
dc.subjectInsulin Resistanceen
dc.subjectAdulten
dc.subjectMiddle Ageden
dc.subjectEndurance Trainingen
dc.subjectMuscle, Skeletal/metabolismen
dc.subjectTriglycerides/metabolismen
dc.subjectR Medicineen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Physics and Astronomyen
dc.subjectSupplementary Informationen
dc.subjecthttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-024-47843-y/MediaObjects/41467_2024_47843_MOESM1_ESM.pdfen
dc.subject.lccRen
dc.titleComparison of intramyocellular lipid metabolism in patients with diabetes and male athletesen
dc.typeJournal articleen

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