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Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ : results from the D-SIRe2 randomised controlled trial

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dc.contributor.authorMaboshe, Wakunyambo F
dc.contributor.authorMacDonald, Helen M.
dc.contributor.authorWassall, Heather
dc.contributor.authorFraser, William D.
dc.contributor.authorTang, Jonathan C Y
dc.contributor.authorFielding, Shona
dc.contributor.authorBarker, Robert N
dc.contributor.authorVickers, Mark A
dc.contributor.authorOrmerod, Anthony
dc.contributor.authorThies, Frank
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2021-06-28T09:50:01Z
dc.date.available2021-06-28T09:50:01Z
dc.date.issued2021-06-28
dc.descriptionACKNOWLEDGMENTS We gratefully acknowledge all participants, the assistance of Karen Secombes for sample collection, Megan Forrester for advising on cytokine and flow cytometry analyses, and Rebecca Barr for packaging and blinding the supplement capsules. Vit D3 supplements were donated by Pure Encapsulations (Sudbury, MA). FUNDING Pathways to a healthy lifestyle studentship, RANK prize funding (WM), University of Aberdeen Development fund (HM), NHS endowments EA0702 (AO), Rural and Environment Science and Analytical Services Division of the Scottish government (RESAS) (FT). This research was funded in whole, or in part, by the Wellcome Trust [Grant number 094847/Z/10/Z]. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent2248546
dc.identifier194310506
dc.identifierc4d874ee-0b08-4aa1-afa8-6f580703e146
dc.identifier85109816222
dc.identifier000671897100001
dc.identifier34262557
dc.identifier.citationMaboshe, W F, MacDonald, H M, Wassall, H, Fraser, W D, Tang, J C Y, Fielding, S, Barker, R N, Vickers, M A, Ormerod, A & Thies, F 2021, 'Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ : results from the D-SIRe2 randomised controlled trial', Frontiers in Immunology, vol. 12, 623087. https://doi.org/10.3389/fimmu.2021.623087en
dc.identifier.doi10.3389/fimmu.2021.623087
dc.identifier.issn1664-3224
dc.identifier.otherORCID: /0000-0002-3154-1040/work/96307936
dc.identifier.otherORCID: /0000-0002-9275-9713/work/99981942
dc.identifier.urihttps://hdl.handle.net/2164/16742
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunologyen
dc.subjectVitamin Den
dc.subjectrandomized control trialen
dc.subjectT regulatory cellsen
dc.subjectinterferon-gammaen
dc.subjectseasonalityen
dc.subjecthealthy subjectsen
dc.subjectimmune markersen
dc.subjectQR180 Immunologyen
dc.subjectR Medicineen
dc.subjectRural and Environmental Science and Analytical Services (RESAS)en
dc.subjectOtheren
dc.subjectEA0702en
dc.subjectWellcome Trusten
dc.subject094847/Z/10/Zen
dc.subject.lccQR180en
dc.subject.lccRen
dc.titleLow-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ : results from the D-SIRe2 randomised controlled trialen
dc.typeJournal articleen

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