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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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dc.contributor.authorDavies, Gail
dc.contributor.authorLam, Max
dc.contributor.authorHarris, Sarah E
dc.contributor.authorTrampush, Joey W
dc.contributor.authorLuciano, Michelle
dc.contributor.authorHill, W David
dc.contributor.authorHagenaars, Saskia P
dc.contributor.authorRitchie, Stuart J
dc.contributor.authorMarioni, Riccardo E
dc.contributor.authorFawns-Ritchie, Chloe
dc.contributor.authorLiewald, David C M
dc.contributor.authorOkely, Judith A
dc.contributor.authorAhola-Olli, Ari V
dc.contributor.authorBarnes, Catriona L K
dc.contributor.authorBertram, Lars
dc.contributor.authorBis, Joshua C
dc.contributor.authorBurdick, Katherine E
dc.contributor.authorChristoforou, Andrea
dc.contributor.authorDeRosse, Pamela
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorGiakoumaki, Stella
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGustavson, Daniel E
dc.contributor.authorHayward, Caroline
dc.contributor.authorHofer, Edith
dc.contributor.authorIkram, M Arfan
dc.contributor.authorKarlsson, Robert
dc.contributor.authorKnowles, Emma
dc.contributor.authorLahti, Jari
dc.contributor.authorLeber, Markus
dc.contributor.authorLi, Shuo
dc.contributor.authorMather, Karen A
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMorris, Derek
dc.contributor.authorOldmeadow, Christopher
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorPayton, Antony
dc.contributor.authorPazoki, Raha
dc.contributor.authorPetrovic, Katja
dc.contributor.authorReynolds, Chandra A
dc.contributor.authorSargurupremraj, Muralidharan
dc.contributor.authorScholz, Markus
dc.contributor.authorSmith, Jennifer A
dc.contributor.authorSmith, Albert V
dc.contributor.authorTerzikhan, Natalie
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTrompet, Stella
dc.contributor.authorvan der Lee, Sven J
dc.contributor.authorWare, Erin B
dc.contributor.authorWindham, B Gwen
dc.contributor.authorWright, Margaret J
dc.contributor.authorYang, Jingyun
dc.contributor.authorYu, Jin
dc.contributor.authorAmes, David
dc.contributor.authorAmin, Najaf
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorAndreassen, Ole A
dc.contributor.authorArmstrong, Nicola J
dc.contributor.authorAssareh, Amelia A
dc.contributor.authorAttia, John R
dc.contributor.authorAttix, Deborah
dc.contributor.authorAvramopoulos, Dimitrios
dc.contributor.authorBennett, David A
dc.contributor.authorBöhmer, Anne C
dc.contributor.authorBoyle, Patricia A
dc.contributor.authorBrodaty, Henry
dc.contributor.authorCampbell, Harry
dc.contributor.authorCannon, Tyrone D
dc.contributor.authorCirulli, Elizabeth T
dc.contributor.authorCongdon, Eliza
dc.contributor.authorConley, Emily Drabant
dc.contributor.authorCorley, Janie
dc.contributor.authorCox, Simon R
dc.contributor.authorDale, Anders M
dc.contributor.authorDehghan, Abbas
dc.contributor.authorDick, Danielle
dc.contributor.authorDickinson, Dwight
dc.contributor.authorEriksson, Johan G
dc.contributor.authorEvangelou, Evangelos
dc.contributor.authorFaul, Jessica D
dc.contributor.authorFord, Ian
dc.contributor.authorFreimer, Nelson A
dc.contributor.authorGao, He
dc.contributor.authorGiegling, Ina
dc.contributor.authorGillespie, Nathan A
dc.contributor.authorGordon, Scott D
dc.contributor.authorGottesman, Rebecca F
dc.contributor.authorGriswold, Michael E
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B
dc.contributor.authorHartmann, Annette M
dc.contributor.authorHatzimanolis, Alex
dc.contributor.authorHeiss, Gerardo
dc.contributor.authorHolliday, Elizabeth G
dc.contributor.authorJoshi, Peter K
dc.contributor.authorKähönen, Mika
dc.contributor.authorKardia, Sharon L R
dc.contributor.authorKarlsson, Ida
dc.contributor.authorKleineidam, Luca
dc.contributor.authorKnopman, David S
dc.contributor.authorKochan, Nicole A
dc.contributor.authorKonte, Bettina
dc.contributor.authorKwok, John B
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLee, Teresa
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLi, Shu-Chen
dc.contributor.authorLiu, Tian
dc.contributor.authorKoini, Marisa
dc.contributor.authorLondon, Edythe
dc.contributor.authorLongstreth, Will T
dc.contributor.authorLopez, Oscar L
dc.contributor.authorLoukola, Anu
dc.contributor.authorLuck, Tobias
dc.contributor.authorLundervold, Astri J
dc.contributor.authorLundquist, Anders
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorMurray, Alison D
dc.contributor.authorNeed, Anna C
dc.contributor.authorNoordam, Raymond
dc.contributor.authorNyberg, Lars
dc.contributor.authorOllier, William
dc.contributor.authorPapenberg, Goran
dc.contributor.authorPattie, Alison
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPoldrack, Russell A
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorReppermund, Simone
dc.contributor.authorRiedel-Heller, Steffi G
dc.contributor.authorRose, Richard J
dc.contributor.authorRotter, Jerome I
dc.contributor.authorRoussos, Panos
dc.contributor.authorRovio, Suvi P
dc.contributor.authorSaba, Yasaman
dc.contributor.authorSabb, Fred W
dc.contributor.authorSachdev, Perminder S
dc.contributor.authorSatizabal, Claudia L
dc.contributor.authorSchmid, Matthias
dc.contributor.authorScott, Rodney J
dc.contributor.authorScult, Matthew A
dc.contributor.authorSimino, Jeannette
dc.contributor.authorSlagboom, P Eline
dc.contributor.authorSmyrnis, Nikolaos
dc.contributor.authorSoumaré, Aïcha
dc.contributor.authorStefanis, Nikos C
dc.contributor.authorStott, David J
dc.contributor.authorStraub, Richard E
dc.contributor.authorSundet, Kjetil
dc.contributor.authorTaylor, Adele M
dc.contributor.authorTaylor, Kent D
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorTzourio, Christophe
dc.contributor.authorUitterlinden, André
dc.contributor.authorVitart, Veronique
dc.contributor.authorVoineskos, Aristotle N
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorWagner, Michael
dc.contributor.authorWagner, Holger
dc.contributor.authorWeinhold, Leonie
dc.contributor.authorWen, K Hoyan
dc.contributor.authorWiden, Elisabeth
dc.contributor.authorYang, Qiong
dc.contributor.authorZhao, Wei
dc.contributor.authorAdams, Hieab H H
dc.contributor.authorArking, Dan E
dc.contributor.authorBilder, Robert M
dc.contributor.authorBitsios, Panos
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorChiba-Falek, Ornit
dc.contributor.authorCorvin, Aiden
dc.contributor.authorDe Jager, Philip L
dc.contributor.authorDebette, Stéphanie
dc.contributor.authorDonohoe, Gary
dc.contributor.authorElliott, Paul
dc.contributor.authorFitzpatrick, Annette L
dc.contributor.authorGill, Michael
dc.contributor.authorGlahn, David C
dc.contributor.authorHägg, Sara
dc.contributor.authorHansell, Narelle K
dc.contributor.authorHariri, Ahmad R
dc.contributor.authorIkram, M Kamran
dc.contributor.authorJukema, J Wouter
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorKeller, Matthew C
dc.contributor.authorKremen, William S
dc.contributor.authorLauner, Lenore
dc.contributor.authorLindenberger, Ulman
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorPendleton, Neil
dc.contributor.authorPorteous, David J
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorRamirez, Alfredo
dc.contributor.authorReinvang, Ivar
dc.contributor.authorRudan, Igor
dc.contributor.authorDan Rujescu
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSchmidt, Helena
dc.contributor.authorSchofield, Peter W
dc.contributor.authorSchofield, Peter R
dc.contributor.authorStarr, John M
dc.contributor.authorSteen, Vidar M
dc.contributor.authorTrollor, Julian N
dc.contributor.authorTurner, Steven T
dc.contributor.authorVan Duijn, Cornelia M
dc.contributor.authorVillringer, Arno
dc.contributor.authorWeinberger, Daniel R
dc.contributor.authorWeir, David R
dc.contributor.authorWilson, James F
dc.contributor.authorMalhotra, Anil
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorGale, Catharine R
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorMosley, Thomas H
dc.contributor.authorBressler, Jan
dc.contributor.authorLencz, Todd
dc.contributor.authorDeary, Ian J
dc.contributor.authorLill, Christina M.
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2018-06-25T18:21:08Z
dc.date.available2018-06-25T18:21:08Z
dc.date.issued2018-05-29
dc.descriptionThis research was conducted in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council (MR/K026992/1). This research was conducted using the UK Biobank Resource (Application Nos. 10279 and 4844). The Neurology Working Group within the Cohorts for Heart and Aging Research in Genomic Epidemiology is partly supported by grants from the National Institute on Aging (R01 AG033193, U01 AG049505 and U01 AG052409). Cohort-specific acknowledgements are in Supplementary Note 3. 01 May 2019 Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.en
dc.description.statusPeer revieweden
dc.format.extent3297821
dc.identifier125595893
dc.identifier2e64bfae-42bc-488a-94a3-852bad7a9b20
dc.identifier29844566
dc.identifier85048027481
dc.identifier000466339700001
dc.identifier.citationDavies, G, Lam, M, Harris, S E, Trampush, J W, Luciano, M, Hill, W D, Hagenaars, S P, Ritchie, S J, Marioni, R E, Fawns-Ritchie, C, Liewald, D C M, Okely, J A, Ahola-Olli, A V, Barnes, C L K, Bertram, L, Bis, J C, Burdick, K E, Christoforou, A, DeRosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, D E, Hayward, C, Hofer, E, Ikram, M A, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, K A, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, C A, Sargurupremraj, M, Scholz, M, Smith, J A, Smith, A V, Terzikhan, N, Thalamuthu, A, Trompet, S, van der Lee, S J, Ware, E B, Windham, B G, Wright, M J, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, O A, Armstrong, N J, Assareh, A A, Attia, J R, Attix, D, Avramopoulos, D, Bennett, D A, Böhmer, A C, Boyle, P A, Brodaty, H, Campbell, H, Cannon, T D, Cirulli, E T, Congdon, E, Conley, E D, Corley, J, Cox, S R, Dale, A M, Dehghan, A, Dick, D, Dickinson, D, Eriksson, J G, Evangelou, E, Faul, J D, Ford, I, Freimer, N A, Gao, H, Giegling, I, Gillespie, N A, Gordon, S D, Gottesman, R F, Griswold, M E, Gudnason, V, Harris, T B, Hartmann, A M, Hatzimanolis, A, Heiss, G, Holliday, E G, Joshi, P K, Kähönen, M, Kardia, S L R, Karlsson, I, Kleineidam, L, Knopman, D S, Kochan, N A, Konte, B, Kwok, J B, Le Hellard, S, Lee, T, Lehtimäki, T, Li, S-C, Liu, T, Koini, M, London, E, Longstreth, W T, Lopez, O L, Loukola, A, Luck, T, Lundervold, A J, Lundquist, A, Lyytikäinen, L-P, Martin, N G, Montgomery, G W, Murray, A D, Need, A C, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, R A, Psaty, B M, Reppermund, S, Riedel-Heller, S G, Rose, R J, Rotter, J I, Roussos, P, Rovio, S P, Saba, Y, Sabb, F W, Sachdev, P S, Satizabal, C L, Schmid, M, Scott, R J, Scult, M A, Simino, J, Slagboom, P E, Smyrnis, N, Soumaré, A, Stefanis, N C, Stott, D J, Straub, R E, Sundet, K, Taylor, A M, Taylor, K D, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, A N, Kaprio, J, Wagner, M, Wagner, H, Weinhold, L, Wen, K H, Widen, E, Yang, Q, Zhao, W, Adams, H H H, Arking, D E, Bilder, R M, Bitsios, P, Boerwinkle, E, Chiba-Falek, O, Corvin, A, De Jager, P L, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, A L, Gill, M, Glahn, D C, Hägg, S, Hansell, N K, Hariri, A R, Ikram, M K, Jukema, J W, Vuoksimaa, E, Keller, M C, Kremen, W S, Launer, L, Lindenberger, U, Palotie, A, Pedersen, N L, Pendleton, N, Porteous, D J, Räikkönen, K, Raitakari, O T, Ramirez, A, Reinvang, I, Rudan, I, Dan Rujescu, Schmidt, R, Schmidt, H, Schofield, P W, Schofield, P R, Starr, J M, Steen, V M, Trollor, J N, Turner, S T, Van Duijn, C M, Villringer, A, Weinberger, D R, Weir, D R, Wilson, J F, Malhotra, A, McIntosh, A M, Gale, C R, Seshadri, S, Mosley, T H, Bressler, J, Lencz, T, Deary, I J & Lill, C M 2018, 'Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function', Nature Communications, vol. 9, no. 1, 2098. https://doi.org/10.1038/s41467-018-04362-x, https://doi.org/10.1038/s41467-019-10160-wen
dc.identifier.doi10.1038/s41467-018-04362-x
dc.identifier.iss1en
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC5974083
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976583
dc.identifier.urihttp://hdl.handle.net/2164/10660
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcognitive neuroscienceen
dc.subjectgenetics of the nervous systemen
dc.subjectGenome-wide association studiesen
dc.subjectquantitative traiten
dc.subjectR Medicine (General)en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K026992/1en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive functionen
dc.typeJournal articleen

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