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The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation

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dc.contributor.authorHumphries, Matthew P.
dc.contributor.authorCraig, Stephanie G.
dc.contributor.authorKacprzyk, Rafal
dc.contributor.authorFisher, Natalie C.
dc.contributor.authorBingham, Victoria
dc.contributor.authorMcQuaid, Stephen
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorMcManus, Damian
dc.contributor.authorTurkington, Richard C.
dc.contributor.authorJames, Jacqueline
dc.contributor.authorSalto-Tellez, Manuel
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2020-06-03T09:15:01Z
dc.date.available2020-06-03T09:15:01Z
dc.date.issued2020-06-01
dc.descriptionAcknowledgments The samples used in this research were received from the Northern Ireland Biobank, which has ethical approval to use de-identified tissue samples from the Belfast Health and Social Care Tissue Pathology archive (REC:11/NI/0013). The Northern Ireland Molecular Pathology Laboratory, was responsible for construction of tissue microarrays, slide staining, and scanning. We are grateful to the NVIDIA Corporation for supporting our research via the GPU Grant Program for researchers. The research leading to these results has also received funding from Invest Northern Ireland. The authors thank Mr. Ken Arthur for the construction of the original tissue microarrays used in this study. Funding This study was funded by a CRUK Accelerator Grant (A20256) to JJ and MST. CRUK had no role in the study design, collection, analysis, and interpretation of the data or in the writing of the report.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent2137791
dc.identifier170338206
dc.identifier52c8c039-8912-4066-b667-100b1ebee248
dc.identifier85085910113
dc.identifier000538120900001
dc.identifier32487090
dc.identifier.citationHumphries, M P, Craig, S G, Kacprzyk, R, Fisher, N C, Bingham, V, McQuaid, S, Murray, G I, McManus, D, Turkington, R C, James, J & Salto-Tellez, M 2020, 'The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation', BMC Cancer, vol. 20, 500. https://doi.org/10.1186/s12885-020-06987-yen
dc.identifier.doi10.1186/s12885-020-06987-y
dc.identifier.issn1471-2407
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973683
dc.identifier.urihttps://hdl.handle.net/2164/14430
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85085910113&partnerID=8YFLogxKen
dc.identifier.vol20en
dc.language.isoeng
dc.relation.ispartofBMC Canceren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectEsophageal adenocarcinomaen
dc.subjectImmune checkpointen
dc.subjectMultiplex IHCen
dc.subjectImage analysisen
dc.subjectBIOMARKERSen
dc.subjectSURVIVALen
dc.subjectPROGRAMMED DEATH-1en
dc.subjectPROGNOSTIC-SIGNIFICANCEen
dc.subjectLARGE COHORTen
dc.subjectCANCERen
dc.subjectLIGAND 1 EXPRESSIONen
dc.subjectR Medicine (General)en
dc.subjectGeneticsen
dc.subjectOncologyen
dc.subjectCancer Researchen
dc.subjectCancer Research UKen
dc.subjectA20256en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleThe adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitationen
dc.typeJournal articleen

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