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The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice

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dc.contributor.authorHu, Sumei
dc.contributor.authorWang, Lu
dc.contributor.authorTogo, Jacques
dc.contributor.authorYang, Dengbao
dc.contributor.authorXu, Yanchao
dc.contributor.authorWu, Yingga
dc.contributor.authorDouglas, Alex
dc.contributor.authorSpeakman, John R.
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Statisticsen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Environment and Food Securityen
dc.contributor.institutionUniversity of Aberdeen.Energetics Research Groupen
dc.date.accessioned2020-01-22T16:30:03Z
dc.date.available2020-01-22T16:30:03Z
dc.date.issued2020-02-01
dc.descriptionAcknowledgments This study was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100), the K.C. Wong Foundation, the 1000 Talents Program, and a Wolfson Merit Award to J.R.S. We thank those in the molecular energetics group in Beijing who contributed to handling the animals and the measurement of their food intake and body weight, including L. Li, B. Li, M. Li, G. Wang, X. Zhang, J. Li, C. Niu, E. Couper, A. Whittington-Davies, and M. Mazidi. Author contributions S.H. was involved in the initial experiment design, conducted experiment one, analyzed the data from experiments one and two, performed the IPA-related analysis, and co-wrote the manuscript. L.W. was involved in the sample collection for experiments one and two and conducted the RNA extractions and the RNA-seq. J.T. was involved in the sample and data collection for experiments one and two. D.Y. and Y.X. performed the initial data collection and glucose measurements for experiment two. Y.W. conducted the insulin measurements and was involved in the initial data collection for experiment two. A.D. was involved in the RNA-seq-related analysis. J.R.S. directed both projects, conceived and designed the experiments, contributed to the data analysis, and co-wrote the paper. All of the authors approved the final version prior to submission for publication.en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent6132278
dc.identifier155569290
dc.identifier8370437b-3fee-41f4-856a-a31c1915f0e7
dc.identifier85076698042
dc.identifier000510843500003
dc.identifier.citationHu, S, Wang, L, Togo, J, Yang, D, Xu, Y, Wu, Y, Douglas, A & Speakman, J R 2020, 'The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice', Molecular Metabolism, vol. 32, pp. 27-43. https://doi.org/10.1016/j.molmet.2019.11.010en
dc.identifier.doi10.1016/j.molmet.2019.11.010
dc.identifier.issn2212-8778
dc.identifier.otherunpaywall: 10.1016/j.molmet.2019.11.010
dc.identifier.otherORCID: /0000-0001-6606-1058/work/103322160
dc.identifier.urihttps://hdl.handle.net/2164/13558
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85076698042&partnerID=8YFLogxKen
dc.identifier.vol32en
dc.language.isoeng
dc.relation.ispartofMolecular Metabolismen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectCarbohydrate-insulin model (CIM)en
dc.subjectEnergy expenditureen
dc.subjectEnergy intakeen
dc.subjectInsulinen
dc.subjectMiceen
dc.subjectFOOD-INTAKEen
dc.subjectGLYCEMIC-INDEXen
dc.subjectFEMALE MICEen
dc.subjectHIGH-FAT DIETSen
dc.subjectKETOGENIC DIETen
dc.subjectNEUROPEPTIDE-Yen
dc.subjectRESPIRATORY EXCHANGE RATIOen
dc.subjectOBESITYen
dc.subjectENERGY-EXPENDITUREen
dc.subjectGLUCOSEen
dc.subjectQH301 Biologyen
dc.subjectMolecular Biologyen
dc.subjectCell Biologyen
dc.subjectSupplementary Dataen
dc.subject.lccQH301en
dc.titleThe carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of miceen
dc.typeJournal articleen

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