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The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

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dc.contributor.authorMapperley, Christopher
dc.contributor.authorvan de Lagemaat, Louie N
dc.contributor.authorLawson, Hannah
dc.contributor.authorTavosanis, Andrea
dc.contributor.authorParis, Jasmin
dc.contributor.authorCampos, Joana
dc.contributor.authorWotherspoon, David
dc.contributor.authorDurko, Jozef
dc.contributor.authorSarapuu, Annika
dc.contributor.authorChoe, Junho
dc.contributor.authorIvanova, Ivayla
dc.contributor.authorKrause, Daniela S
dc.contributor.authorvon Kriegsheim, Alex
dc.contributor.authorMuch, Christian
dc.contributor.authorMorgan, Marcos
dc.contributor.authorGregory, Richard I
dc.contributor.authorMead, Adam J
dc.contributor.authorO'Carroll, Dónal
dc.contributor.authorKranc, Kamil R
dc.date.accessioned2023-09-27T10:44:01Z
dc.date.available2023-09-27T10:44:01Z
dc.date.issued2021-03-01
dc.descriptionK.R. Kranc’s laboratory is funded by a Cancer Research UK program grant (C29967/A26787) and project grants from the Medical Research Council, Blood Cancer UK, Barts Charity, and the Kay Kendall Leukaemia Fund. This research was supported by Wellcome Trust funding to D. O’Carroll (106144) and the Wellcome Centre for Cell Biology (203149). Part of this work was carried out in the framework of the European Cooperation in Science and Technology EPITRAN CA16120. C. Mapperley is funded by a Wellcome Trust PhD studentship (108906/Z/15/Z).en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent4928691
dc.identifier272592402
dc.identifiereea6eaf4-5694-4c1b-a844-a4793fdf4e1d
dc.identifier33156926
dc.identifier85095802769
dc.identifier.citationMapperley, C, van de Lagemaat, L N, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, D S, von Kriegsheim, A, Much, C, Morgan, M, Gregory, R I, Mead, A J, O'Carroll, D & Kranc, K R 2021, 'The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function', Journal of Experimental Medicine, vol. 218, no. 3, e20200829. https://doi.org/10.1084/jem.20200829en
dc.identifier.doi10.1084/jem.20200829
dc.identifier.iss3en
dc.identifier.issn0022-1007
dc.identifier.otherPubMedCentral: PMC7653684
dc.identifier.otherORCID: /0000-0002-2947-1557/work/143414080
dc.identifier.urihttps://hdl.handle.net/2164/21771
dc.identifier.vol218en
dc.language.isoeng
dc.relation.ispartofJournal of Experimental Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAdenosine/analogs & derivativesen
dc.subjectAnimalsen
dc.subjectCell Lineageen
dc.subjectCell Proliferationen
dc.subjectCellular Senescenceen
dc.subjectGene Deletionen
dc.subjectHematopoiesisen
dc.subjectHematopoietic Stem Cell Transplantationen
dc.subjectHematopoietic Stem Cells/metabolismen
dc.subjectInflammation/geneticsen
dc.subjectLymphocytes/metabolismen
dc.subjectMice, Inbred C57BLen
dc.subjectMyeloid Cells/metabolismen
dc.subjectRNA, Messenger/geneticsen
dc.subjectRNA-Binding Proteins/metabolismen
dc.subjectR Medicine (General)en
dc.subjectCancer Research UKen
dc.subjectC29967/A26787en
dc.subjectMedical Research Council (MRC)en
dc.subjectWellcome Trusten
dc.subject106144en
dc.subject203149en
dc.subject108906/Z/15/Zen
dc.subjectSupplementary Dataen
dc.subjectSupplementary Informationen
dc.subject.lccR1en
dc.titleThe mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell functionen
dc.typeJournal articleen

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