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Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N

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dc.contributor.authorDalby, Matthew J.
dc.contributor.authorAviello, Gabriella
dc.contributor.authorRoss, Alexander W.
dc.contributor.authorWalker, Alan W.
dc.contributor.authorBarrett, Perry
dc.contributor.authorMorgan, Peter J.
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Centre for Genome-Enabled Biology and Medicineen
dc.date.accessioned2018-10-23T10:10:08Z
dc.date.available2018-10-23T10:10:08Z
dc.date.issued2018-10-23
dc.descriptionThe authors gratefully acknowledge Doctoral Training Partnership funding from the BBSRC (M.J.D.), MRC (GA) and funding from the Scottish Government (P.J.M., A.W.R., A.W.W. and P.B.). The authors would like to acknowledge the support of the Maxwell compute cluster funded by the University of Aberdeen. We also thank the Centre for Genome-Enabled Biology and Medicine, University of Aberdeen for performing next-generation sequencing and RNAseq, Dr Sophie Shaw, for bioinformatic analysis of the RNAseq data, and Lynn Thomson for assistance with the TLR4−/− and CD14−/− mouse study, and Dr Richard Anderson and Dana Wilson for assistance with the long term high fat diet study. Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-33928-4.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent2279419
dc.identifier139808808
dc.identifiera59fc6b1-6878-45f4-9366-5fbab3a87300
dc.identifier30353127
dc.identifier85055607307
dc.identifier.citationDalby, M J, Aviello, G, Ross, A W, Walker, A W, Barrett, P & Morgan, P J 2018, 'Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N', Scientific Reports, vol. 8, 15648. https://doi.org/10.1038/s41598-018-33928-4en
dc.identifier.doi10.1038/s41598-018-33928-4
dc.identifier.issn2045-2322
dc.identifier.otherORCID: /0000-0001-5099-8495/work/49699474
dc.identifier.otherORCID: /0000-0002-5071-6512/work/74327459
dc.identifier.otherORCID: /0000-0003-3604-2950/work/76975677
dc.identifier.otherORCID: /0000-0002-1799-1432/work/96308187
dc.identifier.urihttp://hdl.handle.net/2164/11307
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectMetabolic Endotoxemiaen
dc.subjectHypothalamic Inflammationen
dc.subjectCaecal Microbiotaen
dc.subjectMicrobiota Compositionen
dc.subjectArcuate Nucleusen
dc.subjectR Medicine (General)en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectMedical Research Council (MRC)en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleDiet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3Nen
dc.typeJournal articleen

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