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A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency

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dc.contributor.authorWestbury, Sarah K.
dc.contributor.authorWhyte, Claire S.
dc.contributor.authorStephens, Jonathan
dc.contributor.authorDownes, Kate
dc.contributor.authorTurro, Ernest
dc.contributor.authorClaesen, Karen
dc.contributor.authorMertens, Joachim C
dc.contributor.authorHendriks, Dirk
dc.contributor.authorLatif, Anne‐Louise
dc.contributor.authorLeishman, Emma J
dc.contributor.authorNIHR BioResource
dc.contributor.authorMutch, Nicola J.
dc.contributor.authorCampbell Tait, R.
dc.contributor.authorMumford, Andrew D.
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2020-09-08T10:20:01Z
dc.date.available2020-09-08T10:20:01Z
dc.date.issued2020-09
dc.descriptionACKNOWLEDGEMENTS We thank NIHR BioResource volunteers for their participation, and gratefully acknowledge NIHR BioResource centres, NHS Trusts and staff for their contribution. We thank the National Institute for Health Research and NHS Blood and Transplant. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. S.K.W. was supported during this work by the Medical Research Council (MR/K023489/1) and is now funded through an NIHR-funded Academic Clinical Lectureship. K.D. is supported as a HSST trainee by NHS Health Education England. N.J.M. and C.S.W. are supported by the British Heart Foundation (PG/15/82/31721). J.C.M. is a fellow of the Research Foundation Flanders (FWO Vlaanderen; 1137717N). A.D.M. is supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol National Health Service Foundation Trust and the University of Bristol. We thank Prof Paul Declerck and Prof Ann Gils, University Leuven, Belgium for the kind gift of the MA-T12D11 antibody. We acknowledge technical assistance from Dorien Leenaerts, University of Antwerp, Belgium and Michela Donnarumma, University of Aberdeen, UK.en
dc.description.statusPeer revieweden
dc.format.extent6
dc.format.extent848625
dc.identifier172489838
dc.identifierb6556bc2-1737-4977-85c7-e9929db9ebac
dc.identifier32634856
dc.identifier85088364370
dc.identifier000551211600001
dc.identifier.citationWestbury, S K, Whyte, C S, Stephens, J, Downes, K, Turro, E, Claesen, K, Mertens, J C, Hendriks, D, Latif, AL, Leishman, E J, NIHR BioResource, Mutch, N J, Campbell Tait, R & Mumford, A D 2020, 'A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency', Journal of Thrombosis and Haemostasis, vol. 18, no. 9, pp. 2209-2214. https://doi.org/10.1111/jth.14990en
dc.identifier.doi10.1111/jth.14990
dc.identifier.iss9en
dc.identifier.issn1538-7933
dc.identifier.otherORCID: /0000-0001-8127-6102/work/101050685
dc.identifier.otherORCID: /0000-0002-7452-0813/work/169538847
dc.identifier.urihttps://hdl.handle.net/2164/15105
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85088364370&partnerID=8YFLogxKen
dc.identifier.vol18en
dc.language.isoeng
dc.relation.ispartofJournal of Thrombosis and Haemostasisen
dc.subjectThrombomodulinen
dc.subjectBleedingen
dc.subjectFibrinolysisen
dc.subjectGenomicsen
dc.subjectTAFI (carboxypeptidase B2 (CPB2)/procarboxypeptidase U (proCPU))en
dc.subjectfibrinolysisen
dc.subjectbleedingen
dc.subjectthrombomodulinen
dc.subjectgenomicsen
dc.subjectTAFI (carboxypeptidase B2 [CPB2]/procarboxypeptidase U [proCPU])en
dc.subjectLYSISen
dc.subjectprocarboxypeptidase U [proCPU])en
dc.subjectDISORDERen
dc.subjectTAFI (carboxypeptidase B2 [CPB2]en
dc.subjectR Medicineen
dc.subjectHematologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K023489/1en
dc.subjectOtheren
dc.subjectBritish Heart Foundationen
dc.subjectPG/15/82/31721en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleA new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiencyen
dc.typeJournal articleen

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