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Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis

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dc.contributor.authorEldridge, Suzanne
dc.contributor.authorBarawi, Aida
dc.contributor.authorWang, Hui
dc.contributor.authorRoelofs, Anke
dc.contributor.authorKaneva, Magdalena
dc.contributor.authorGuan, Zeyu
dc.contributor.authorLydon, Helen
dc.contributor.authorThomas, Bethan L
dc.contributor.authorThorup, Anne-Sophie
dc.contributor.authorFernandez Fernandez, Beatriz
dc.contributor.authorCaxaria, Sara
dc.contributor.authorStrachan, Danielle
dc.contributor.authorAli, Ahmed
dc.contributor.authorShanmuganathan, Kanatheepan
dc.contributor.authorPitzalis, Costantino
dc.contributor.authorWhiteford, James
dc.contributor.authorHenson, Frances
dc.contributor.authorMcCaskie, Andrew
dc.contributor.authorde Bari, Cosimo
dc.contributor.authorDell'Accio, Francesco
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.date.accessioned2020-11-13T11:04:01Z
dc.date.available2020-11-13T11:04:01Z
dc.date.issued2020-09-02
dc.descriptionAcknowledgments: We thank Prof. F. Luyten and Prof. C. Hartman for the critical reading of this manuscript. The authors thank Technical Staff in the ARM Lab and Staff at the University of Aberdeen’s Animal Facility and Microscopy & Histology Facility for their support. Funding: We gratefully acknowledge funding support of this work by the MRC (MR/L022893/1, MR/N010973/1, MR/P026362/1), Versus Arthritis (19667, 21515, 20886, 21621), Rosetrees Trust (A1205), the Medical College of St Bartholomew's Hospital Trust and the William Harvey Research Foundation.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent2985669
dc.identifier174044462
dc.identifier93543930-883f-4a26-aba2-0360a6c32761
dc.identifier32878982
dc.identifier000567648800001
dc.identifier85090260538
dc.identifier.citationEldridge, S, Barawi, A, Wang, H, Roelofs, A, Kaneva, M, Guan, Z, Lydon, H, Thomas, B L, Thorup, A-S, Fernandez Fernandez, B, Caxaria, S, Strachan, D, Ali, A, Shanmuganathan, K, Pitzalis, C, Whiteford, J, Henson, F, McCaskie, A, de Bari, C & Dell'Accio, F 2020, 'Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis', Science translational medicine, vol. 12, no. 559, eaax9086. https://doi.org/10.1126/scitranslmed.aax9086en
dc.identifier.doi10.1126/scitranslmed.aax9086
dc.identifier.iss559en
dc.identifier.issn1946-6242
dc.identifier.otherSCOPUS: 85090260538
dc.identifier.urihttps://hdl.handle.net/2164/15360
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85090260538&partnerID=8YFLogxKen
dc.identifier.urlhttps://www.repository.cam.ac.uk/handle/1810/311896en
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofScience translational medicineen
dc.subjectAMP RESPONSE ELEMENTen
dc.subjectARTICULAR-CARTILAGEen
dc.subjectSYNOVIAL JOINTen
dc.subjectGENE-EXPRESSIONen
dc.subjectSTEM-CELLSen
dc.subjectTGF-BETAen
dc.subjectOSTEOARTHRITISen
dc.subjectPROTEINen
dc.subjectLRP4en
dc.subjectMAINTENANCEen
dc.subjectR Medicineen
dc.subjectGeneral Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L022893/1en
dc.subjectMR/N010973/1en
dc.subjectMR/P026362/1en
dc.subjectOtheren
dc.subject19667en
dc.subject21515en
dc.subject20886en
dc.subject21621en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAgrin induces long-term osteochondral regeneration by supporting repair morphogenesisen
dc.typeJournal articleen

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