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Monoclonal antibodies targeting surface exposed epitopes of Candida albicans cell wall proteins confer in vivo protection in an infection model

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dc.contributor.authorPalliyil, Soumya
dc.contributor.authorMawer, Mark
dc.contributor.authorAlwafi, Sami
dc.contributor.authorFogg, Lily
dc.contributor.authorBuda de Cesare, Giuseppe
dc.contributor.authorTan, Tyng
dc.contributor.authorWalker, Louise
dc.contributor.authorMacCalllum, Donna
dc.contributor.authorPorter, Andrew
dc.contributor.authorMunro, Carol
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2023-08-08T15:05:01Z
dc.date.available2023-08-08T15:05:01Z
dc.date.issued2022-04-19
dc.descriptionACKNOWLEDGMENTS We gratefully acknowledge Kevin McKenzie and Lucy Wight from the University of Aberdeen Microscopy and Histology Facility for training and access to fluorescence microscopy and for their support and assistance in this work. We also gratefully acknowledge David Stead from Aberdeen Proteomics for his support and assistance with the Candida proteome analysis and the staff of the University of Aberdeen Medical Research Facility for their support and assistance with the mouse studies. This work was supported by the following research grants: the High Throughput and Fragment Screening Fund, Scottish Universities Life Sciences Alliance (SULSA); a seed corn award from the University of Aberdeen Wellcome Trust Institutional Strategic Support Fund; an M.Res. studentship by the Medical Research Council Centre for Medical Mycology at the University of Aberdeen (grant number MR/P501955/1); a Ph.D. studentship from the Institute of Medical Sciences, University of Aberdeen; a Ph.D. studentship from Taibah University and a Saudi Government scholarship; and a Ph.D. studentship by the European Union’s Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant agreement number H2020-MSCA-ITN-2014-642095 (OPATHY). C.A.M., S.P., and A.J.P. contributed to the concept and study design. C.A.M. and S.P. developed the methodology. S.A.A. and L.F. performed recombinant antibody generation and ELISAs. L.F. and M.M. completed IgG reformatting and the production of mAbs for animal studies. M.M., T.H.T., and L.A.W. performed ELISAs and immunofluorescence staining. M.M. performed macrophage assays, and D.M.M. planned, conducted, and analyzed animal studies. C.A.M., S.P., and A.J.P. contributed to funding acquisition and project administration, and C.A.M., S.P., and L.A.W. contributed to the supervision and training of M.Res. and Ph.D. students. S.P. wrote the original draft, and C.A.M., D.M.M., and A.J.P. completed review and editing. All authors had full access to the data and approved the manuscript before it was submitted by the corresponding author(s). S.P., A.J.P., and C.A.M. are inventors on a patent related to the development of antifungal antibodies to surface-exposed epitopes of fungal pathogens owned by the University of Aberdeen. All other authors declare that they have no competing interests.en
dc.description.statusPeer revieweden
dc.format.extent2942094
dc.identifier212756155
dc.identifier5fc305c6-0aef-4646-b46a-61b29e5da051
dc.identifier85128479007
dc.identifier000783977300012
dc.identifier.citationPalliyil, S, Mawer, M, Alwafi, S, Fogg, L, Buda de Cesare, G, Tan, T, Walker, L, MacCalllum, D, Porter, A & Munro, C 2022, 'Monoclonal antibodies targeting surface exposed epitopes of Candida albicans cell wall proteins confer in vivo protection in an infection model', Antimicrobial Agents and Chemotherapy, vol. 66, no. 4, e01957-21. https://doi.org/10.1128/aac.01957-21en
dc.identifier.doi10.1128/aac.01957-21
dc.identifier.iss4en
dc.identifier.issn0066-4804
dc.identifier.otherORCID: /0000-0002-2236-8776/work/140425226
dc.identifier.otherORCID: /0000-0003-0761-1755/work/162728995
dc.identifier.urihttps://hdl.handle.net/2164/21437
dc.identifier.vol66en
dc.language.isoeng
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen
dc.subjectCandida albicansen
dc.subjectanti-Candida mAbsen
dc.subjectimmunotherapyen
dc.subjectmonoclonal antibodiesen
dc.subjectR Medicineen
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleMonoclonal antibodies targeting surface exposed epitopes of Candida albicans cell wall proteins confer in vivo protection in an infection modelen
dc.typeJournal articleen

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