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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

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dc.contributor.authorLeeson-Payne, Alasdair
dc.contributor.authorIyinikkel, Jean
dc.contributor.authorMalcolm, Cameron
dc.contributor.authorLam, Brian Y H
dc.contributor.authorSommer, Nadine
dc.contributor.authorDowsett, Georgina K C
dc.contributor.authorBlanco Martinez de Morentin, Pablo
dc.contributor.authorThompson, Dawn
dc.contributor.authorMacKenzie, Alasdair
dc.contributor.authorChianese, Raffaella
dc.contributor.authorKentistou, Katherine A
dc.contributor.authorGardner, Eugene J.
dc.contributor.authorPerry, John R.B.
dc.contributor.authorGrassmann, Felix
dc.contributor.authorSpeakman, John
dc.contributor.authorRochford, Justin
dc.contributor.authorYeo, Giles S. H.
dc.contributor.authorMurray, Fiona
dc.contributor.authorHeisler, Lora
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.contributor.institutionUniversity of Aberdeen.Environment and Food Securityen
dc.contributor.institutionUniversity of Aberdeen.Energetics Research Groupen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.date.accessioned2024-06-13T15:10:59Z
dc.date.available2024-06-13T15:10:59Z
dc.date.issued2024-05-07
dc.descriptionOpen Access via the Elsevier Agreement L.K.H. designed the experiments with input from F.M., G.S.H.Y., and J.J.R.; F.M. and J.I. created the CRISPR-Cas9-deleted Gpr75 mouse line with input from A.M.; A.L.-P., C.M., B.Y.H.L., G.K.C.D., N.S., P.B.M.d.M., R.C., K.K., E.J.G., J.R.B.P., F.G., J.R.S., and J.J.R. performed experiments and/or data analysis; D.T. provided reagents and intellectual contributions; and L.K.H. and A.L.-P. wrote the manuscript with input from all other authors.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent4553585
dc.identifier284408992
dc.identifierfc6b761b-2019-45a1-bf15-267f68f7ab70
dc.identifier38653246
dc.identifier85191954616
dc.identifier.citationLeeson-Payne, A, Iyinikkel, J, Malcolm, C, Lam, B Y H, Sommer, N, Dowsett, G K C, Blanco Martinez de Morentin, P, Thompson, D, MacKenzie, A, Chianese, R, Kentistou, K A, Gardner, E J, Perry, J R B, Grassmann, F, Speakman, J, Rochford, J, Yeo, G S H, Murray, F & Heisler, L 2024, 'Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation', Cell Metabolism, vol. 36, no. 5, pp. 1076-1087. https://doi.org/10.1016/j.cmet.2024.03.016en
dc.identifier.doi10.1016/j.cmet.2024.03.016
dc.identifier.iss5en
dc.identifier.issn1550-4131
dc.identifier.otherORCID: /0000-0003-0948-9458/work/160846872
dc.identifier.otherORCID: /0000-0002-1823-2913/work/160846988
dc.identifier.otherORCID: /0000-0003-2380-7117/work/160847125
dc.identifier.otherORCID: /0000-0003-1390-7528/work/160847673
dc.identifier.otherORCID: /0000-0002-5020-4939/work/160848134
dc.identifier.otherORCID: /0000-0002-5572-4810/work/160848192
dc.identifier.urihttps://hdl.handle.net/2164/23598
dc.identifier.vol36en
dc.language.isoeng
dc.relation.ispartofCell Metabolismen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectG protein-coupled receptoren
dc.subjectGpr75en
dc.subjectNAFLDen
dc.subjectobesityen
dc.subjectphysical activityen
dc.subjectfatty liveren
dc.subjectRC Internal medicineen
dc.subjectSupplementary Informationen
dc.subjecthttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc1.pdfen
dc.subjecthttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc2.xlsxen
dc.subjecthttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc3.zipen
dc.subjecthttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc4.pdfen
dc.subject.lccRCen
dc.titleLoss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulationen
dc.typeJournal articleen

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