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Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

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dc.contributor.authorAlexandrou, Constantinos
dc.contributor.authorAl-Aqbi, Saif Sattar
dc.contributor.authorHiggins, Jennifer A.
dc.contributor.authorBoyle, William
dc.contributor.authorKarmokar, Ankur
dc.contributor.authorAndreadi, Catherine
dc.contributor.authorLuo, Jin-Li
dc.contributor.authorMoore, David A.
dc.contributor.authorViskaduraki, Maria
dc.contributor.authorBlades, Matthew
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorHowells, Lynne M.
dc.contributor.authorThomas, Anne
dc.contributor.authorBrown, Karen
dc.contributor.authorCheng, Paul N.
dc.contributor.authorRufini, Alessandro
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2018-08-14T12:39:06Z
dc.date.available2018-08-14T12:39:06Z
dc.date.issued2018-08-14
dc.descriptionWe thank Polaris Pharmaceuticals and Bio-Cancer Treatment for providing drugs and reagents. This work was supported by the Cancer Prevention Research Trust, with assistance from the Wellcome Trust Institutional Strategic Support Fund [097828/z/11/B], and Cancer Research UK in conjunction with the Department of Health as part of an Experimental Cancer Medicine Centre grant [C325/A15575]. C.A. was funded by a PhD fellowship from the Cancer Prevention Research Trust, S.S.A. was funded by a studentship from the Iraqi Government. We are thankful to John Bomalaski and Sara Galavotti for their critical reading of the manuscript and insightful suggestions. Finally, we are profoundly indebted to Professor Andreas Gescher for his constant support during the execution of this project and the writing of this manuscript.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent5846194
dc.identifier130912758
dc.identifierba73f8c0-e897-4f08-94c1-8068e41d0e89
dc.identifier85053400137
dc.identifier.citationAlexandrou, C, Al-Aqbi, S S, Higgins, J A, Boyle, W, Karmokar, A, Andreadi, C, Luo, J-L, Moore, D A, Viskaduraki, M, Blades, M, Murray, G I, Howells, L M, Thomas, A, Brown, K, Cheng, P N & Rufini, A 2018, 'Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes', Scientific Reports, vol. 8, 12096, pp. 1-14. https://doi.org/10.1038/s41598-018-30591-7en
dc.identifier.doi10.1038/s41598-018-30591-7
dc.identifier.issn2045-2322
dc.identifier.otherRIS: urn:05BFF4E610E5EEB7A2260B9C24266B4E
dc.identifier.otherRIS: Alexandrou2018
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973499
dc.identifier.urihttp://hdl.handle.net/2164/10897
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectWellcome Trusten
dc.subject097828/z/11/Ben
dc.subjectCancer Research UKen
dc.subjectC325/A15575en
dc.subject.lccRC0254en
dc.titleSensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymesen
dc.typeJournal articleen

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