University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Simple item page
dc.contributor.authorWatson, Hunna J.
dc.contributor.authorYilmaz, Zeynep
dc.contributor.authorThornton, Laura M.
dc.contributor.authorHübel, Christopher
dc.contributor.authorColeman, Jonathan R. I.
dc.contributor.authorGaspar, Héléna A.
dc.contributor.authorBryois, Julien
dc.contributor.authorHinney, Anke
dc.contributor.authorLeppä, Virpi M.
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorRipke, Stephan
dc.contributor.authorYao, Shuyang
dc.contributor.authorGiusti-Rodríguez, Paola
dc.contributor.authorHanscombe, Ken B.
dc.contributor.authorPurves, Kirstin L.
dc.contributor.authorAdan, Roger A. H.
dc.contributor.authorAlfredsson, Lars
dc.contributor.authorAndo, Tetsuya
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorBaker, Jessica H.
dc.contributor.authorBerrettini, Wade H.
dc.contributor.authorBoehm, Ilka
dc.contributor.authorBoni, Claudette
dc.contributor.authorPerica, Vesna Boraska
dc.contributor.authorBuehren, Katharina
dc.contributor.authorBurghardt, Roland
dc.contributor.authorCassina, Matteo
dc.contributor.authorCichon, Sven
dc.contributor.authorClementi, Maurizio
dc.contributor.authorCone, Roger D.
dc.contributor.authorCourtet, Philippe
dc.contributor.authorCrow, Scott
dc.contributor.authorCrowley, James J.
dc.contributor.authorDanner, Unna N.
dc.contributor.authorDavis, Oliver S. P.
dc.contributor.authorde Zwaan, Martina
dc.contributor.authorDedoussis, George
dc.contributor.authorDegortes, Daniela
dc.contributor.authorDeSocio, Janiece E.
dc.contributor.authorDick, Danielle M.
dc.contributor.authorDikeos, Dimitris
dc.contributor.authorDina, Christian
dc.contributor.authorDmitrzak-Weglarz, Monika
dc.contributor.authorDocampo, Elisa
dc.contributor.authorDuncan, Laramie E.
dc.contributor.authorEgberts, Karin
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorEscaramís, Geòrgia
dc.contributor.authorEsko, Tõnu
dc.contributor.authorEstivill, Xavier
dc.contributor.authorFarmer, Anne
dc.contributor.authorFavaro, Angela
dc.contributor.authorFernández-Aranda, Fernando
dc.contributor.authorFichter, Manfred M.
dc.contributor.authorFischer, Krista
dc.contributor.authorFöcker, Manuel
dc.contributor.authorForetova, Lenka
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorForzan, Monica
dc.contributor.authorFranklin, Christopher S.
dc.contributor.authorGallinger, Steven
dc.contributor.authorGiegling, Ina
dc.contributor.authorGiuranna, Johanna
dc.contributor.authorGonidakis, Fragiskos
dc.contributor.authorGorwood, Philip
dc.contributor.authorMayora, Monica Gratacos
dc.contributor.authorGuillaume, Sébastien
dc.contributor.authorGuo, Yiran
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorHatzikotoulas, Konstantinos
dc.contributor.authorHauser, Joanna
dc.contributor.authorHebebrand, Johannes
dc.contributor.authorHelder, Sietske G.
dc.contributor.authorHerms, Stefan
dc.contributor.authorHerpertz-Dahlmann, Beate
dc.contributor.authorHerzog, Wolfgang
dc.contributor.authorHuckins, Laura M.
dc.contributor.authorHudson, James I.
dc.contributor.authorImgart, Hartmut
dc.contributor.authorInoko, Hidetoshi
dc.contributor.authorJanout, Vladimir
dc.contributor.authorJiménez-Murcia, Susana
dc.contributor.authorJulià, Antonio
dc.contributor.authorKalsi, Gursharan
dc.contributor.authorKaminská, Deborah
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKarhunen, Leila
dc.contributor.authorKarwautz, Andreas
dc.contributor.authorKas, Martien J. H.
dc.contributor.authorKennedy, James L.
dc.contributor.authorKeski-Rahkonen, Anna
dc.contributor.authorKiezebrink, Kirsty
dc.contributor.authorKim, Youl-Ri
dc.contributor.authorKlareskog, Lars
dc.contributor.authorKlump, Kelly L.
dc.contributor.authorKnudsen, Gun Peggy S.
dc.contributor.authorLa Via, Maria C.
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLevitan, Robert D.
dc.contributor.authorLi, Dong
dc.contributor.authorLilenfeld, Lisa
dc.contributor.authorLin, Bochao Danae
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLuykx, Jurjen
dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorMaj, Mario
dc.contributor.authorMannik, Katrin
dc.contributor.authorMarsal, Sara
dc.contributor.authorMarshall, Christian R.
dc.contributor.authorMattingsdal, Morten
dc.contributor.authorMcDevitt, Sara
dc.contributor.authorMcGuffin, Peter
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMeulenbelt, Ingrid
dc.contributor.authorMicali, Nadia
dc.contributor.authorMitchell, Karen
dc.contributor.authorMonteleone, Alessio Maria
dc.contributor.authorMonteleone, Palmiero
dc.contributor.authorMunn-Chernoff, Melissa A.
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorNavratilova, Marie
dc.contributor.authorNtalla, Ioanna
dc.contributor.authorO’Toole, Julie K.
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorPadyukov, Leonid
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPantel, Jacques
dc.contributor.authorPapezova, Hana
dc.contributor.authorPinto, Dalila
dc.contributor.authorRabionet, Raquel
dc.contributor.authorRaevuori, Anu
dc.contributor.authorRamoz, Nicolas
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorRicca, Valdo
dc.contributor.authorRipatti, Samuli
dc.contributor.authorRitschel, Franziska
dc.contributor.authorRoberts, Marion
dc.contributor.authorRotondo, Alessandro
dc.contributor.authorRujescu, Dan
dc.contributor.authorRybakowski, Filip
dc.contributor.authorSantonastaso, Paolo
dc.contributor.authorScherag, André
dc.contributor.authorScherer, Stephen W.
dc.contributor.authorSchmidt, Ulrike
dc.contributor.authorSchork, Nicholas J.
dc.contributor.authorSchosser, Alexandra
dc.contributor.authorSeitz, Jochen
dc.contributor.authorSlachtova, Lenka
dc.contributor.authorSlagboom, P. Eline
dc.contributor.authorSlof-Op ‘t Landt, Margarita C. T.
dc.contributor.authorSlopien, Agnieszka
dc.contributor.authorSorbi, Sandro
dc.contributor.authorŚwiątkowska, Beata
dc.contributor.authorSzatkiewicz, Jin P.
dc.contributor.authorTachmazidou, Ioanna
dc.contributor.authorTenconi, Elena
dc.contributor.authorTortorella, Alfonso
dc.contributor.authorTozzi, Federica
dc.contributor.authorTreasure, Janet
dc.contributor.authorTsitsika, Artemis
dc.contributor.authorTyszkiewicz-Nwafor, Marta
dc.contributor.authorTziouvas, Konstantinos
dc.contributor.authorvan Elburg, Annemarie A.
dc.contributor.authorvan Furth, Eric F.
dc.contributor.authorWagner, Gudrun
dc.contributor.authorWalton, Esther
dc.contributor.authorWiden, Elisabeth
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorZerwas, Stephanie
dc.contributor.authorZipfel, Stephan
dc.contributor.authorBergen, Andrew W.
dc.contributor.authorBoden, Joseph M.
dc.contributor.authorBrandt, Harry
dc.contributor.authorCrawford, Steven
dc.contributor.authorHalmi, Katherine A.
dc.contributor.authorHorwood, L. John
dc.contributor.authorJohnson, Craig
dc.contributor.authorKaplan, Allan S.
dc.contributor.authorKaye, Walter H.
dc.contributor.authorMitchell, James E.
dc.contributor.authorOlsen, Catherine M.
dc.contributor.authorPearson, John F.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorStrober, Michael
dc.contributor.authorWerge, Thomas
dc.contributor.authorWhiteman, David C.
dc.contributor.authorWoodside, D. Blake
dc.contributor.authorStuber, Garret D.
dc.contributor.authorGordon, Scott
dc.contributor.authorGrove, Jakob
dc.contributor.authorHenders, Anjali K.
dc.contributor.authorJuréus, Anders
dc.contributor.authorKirk, Katherine M.
dc.contributor.authorLarsen, Janne T.
dc.contributor.authorParker, Richard
dc.contributor.authorPetersen, Liselotte
dc.contributor.authorJordan, Jennifer
dc.contributor.authorKennedy, Martin
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorWade, Tracey D.
dc.contributor.authorBirgegård, Andreas
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorNorring, Claes
dc.contributor.authorLandén, Mikael
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMortensen, Preben Bo
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorBreen, Gerome
dc.contributor.authorBulik, Cynthia M.
dc.contributor.authorInitiative, Anorexia Nervosa Genetics
dc.contributor.authorConsortium, Eating Disorders Working Group of the Psychiatric Genomics
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2020-01-15T00:04:22Z
dc.date.available2020-01-15T00:04:22Z
dc.date.embargoedUntil2020-01-15
dc.date.issued2019-08
dc.descriptionGrant support for ANGI, the PGC-ED and its component groups is shown in Supplementary Table 17. We thank all study volunteers, study coordinators and research staff who enabled this study. ANGI: The Anorexia Nervosa Genetics Initiative is an initiative of the Klarman Family Foundation. Additional support was offered by the National Institute of Mental Health. We are deeply grateful to all of the individuals who, through their participation, made ANGI a success. The goodwill that permeated the eating disorders community fueled by the enthusiasm of prominent bloggers, advocates, clinicians, treatment centers, scientists, organizations, families and especially those who have suffered from anorexia nervosa, yielded in an unprecedented and inspired global movement to complete this science. ANGI (United States): We thank Walden Behavioral Care, McCallum Place and the Renfrew Center for assisting with recruitment. We express our gratitude to J. Alexander (http://www.junealexander.com/) and C. Arnold (http://carriearnold.com/), who helped us disseminate information about ANGI. We acknowledge support from the North Carolina Translational and Clinical Sciences Institute (NC TraCS), the Carolina Data Warehouse and the Foundation of Hope, Raleigh, North Carolina. ANGI (Australia and New Zealand): We thank the Australia & and New Zealand Academy for Eating Disorders for assistance with recruitment and publicity. We thank VIVA! Communications for their efforts in promoting the study and the Butterfly Foundation for their ongoing support of anorexia nervosa research in Australia and EDANZ in New Zealand. We thank the QSkin Sun and Health Study for controls. We also acknowledge the assistance of S. Maguire and J. Russell (University of Sydney), P. Hay (Western Sydney University), S. Madden (Western Sydney University and the Sydney Children’s Hospital Network), S. Sawyer and E. Hughes (Royal Children’s Hospital, Melbourne), K. Fairweather-Schmidt (Flinders University), A. Fursland (Centre for Clinical Interventions and Curtin University), J. McCormack (Princess Margaret Hospital for Children), F. Wagg (Royal Hobart Hospital) and W. Ward (Royal Brisbane and Women’s Hospital) in recruitment. We also thank L. Nunn for validation work on the ED100Kv1 Questionnaire. Additionally, administrative support for data collection was received from the Australian Twin Registry, which is supported by an Enabling Grant (ID 310667) from the NHMRC administered by the University of Melbourne. In New Zealand, we also acknowledge assistance with recruitment from M. Roberts (University of Auckland), R. Lawson (South Island Eating Disorders Service), M. Meiklejohn (Auckland District Health Board) and R. Mysliwiec. Special thanks to those who provided their stories in relation to publicity about ANGI. ANGI (Sweden): We acknowledge the assistance of the Stockholm Centre for Eating Disorders (SCÄ) and thank the Swedish National Quality Register for Eating Disorders (Riksät) and Lifegene. We would also like to thank the research nurses and data collectors at the Department of Medical Epidemiology and Biostatistics who worked on ANGI. ANGI (Denmark): We thank the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH). PGC: We are deeply indebted to the investigators who comprise the PGC and to the hundreds of thousands of individuals who have shared their life experiences with PGC investigators and the contributing studies. We are grateful to the Children’s Hospital of Philadelphia (CHOP), the Price Foundation Collaborative Group (PFCG), Genetic Consortium for Anorexia Nervosa (GCAN), Wellcome Trust Case-Control Consortium-3 (WTCCC-3), the UK Biobank and all PGC-ED members for their support in providing individual samples used in this study. We thank SURFsara (http://www.surf.nl) for support in using the Lisa Compute Cluster. We thank M. Lam for Ricopili consultation. This study also represents independent research partly funded by the English National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London and the NIHR BioResource. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the English Department of Health and Social Care. High performance computing facilities were funded with capital equipment grants from the GSTT Charity (TR130505) and Maudsley Charity (980). Research reported in this publication was also supported by the National Institute of Mental Health of the US National Institutes of Health under Award Numbers U01MH109528 and U01MH109514. The content is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institutes of Health.en
dc.description.statusPeer revieweden
dc.format.extent8
dc.format.extent7513786
dc.format.extent2541826
dc.identifier145809104
dc.identifier54ea1e64-45a7-4e1d-933f-c2ae8d0cc04c
dc.identifier85068455956
dc.identifier000477946700007
dc.identifier31308545
dc.identifier.citationWatson, H J, Yilmaz, Z, Thornton, L M, Hübel, C, Coleman, J R I, Gaspar, H A, Bryois, J, Hinney, A, Leppä, V M, Mattheisen, M, Medland, S E, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, K B, Purves, K L, Adan, R A H, Alfredsson, L, Ando, T, Andreassen, O A, Baker, J H, Berrettini, W H, Boehm, I, Boni, C, Perica, V B, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, R D, Courtet, P, Crow, S, Crowley, J J, Danner, U N, Davis, O S P, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J E, Dick, D M, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, L E, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, M M, Fischer, K, Föcker, M, Foretova, L, Forstner, A J, Forzan, M, Franklin, C S, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Mayora, M G, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, S G, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, L M, Hudson, J I, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Kaprio, J, Karhunen, L, Karwautz, A, Kas, M J H, Kennedy, J L, Keski-Rahkonen, A, Kiezebrink, K, Kim, Y-R, Klareskog, L, Klump, K L, Knudsen, G P S, La Via, M C, Le Hellard, S, Levitan, R D, Li, D, Lilenfeld, L, Lin, B D, Lissowska, J, Luykx, J, Magistretti, P J, Maj, M, Mannik, K, Marsal, S, Marshall, C R, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, A M, Monteleone, P, Munn-Chernoff, M A, Nacmias, B, Navratilova, M, Ntalla, I, O’Toole, J K, Ophoff, R A, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, S W, Schmidt, U, Schork, N J, Schosser, A, Seitz, J, Slachtova, L, Slagboom, P E, Slof-Op ‘t Landt, M C T, Slopien, A, Sorbi, S, Świątkowska, B, Szatkiewicz, J P, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, A A, van Furth, E F, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, A W, Boden, J M, Brandt, H, Crawford, S, Halmi, K A, Horwood, L J, Johnson, C, Kaplan, A S, Kaye, W H, Mitchell, J E, Olsen, C M, Pearson, J F, Pedersen, N L, Strober, M, Werge, T, Whiteman, D C, Woodside, D B, Stuber, G D, Gordon, S, Grove, J, Henders, A K, Juréus, A, Kirk, K M, Larsen, J T, Parker, R, Petersen, L, Jordan, J, Kennedy, M, Montgomery, G W, Wade, T D, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Martin, N G, Mortensen, P B, Sullivan, P F, Breen, G, Bulik, C M, Initiative, A N G & Consortium, E D W G O T P G 2019, 'Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa', Nature Genetics, vol. 51, pp. 1207-1214. https://doi.org/10.1038/s41588-019-0439-2en
dc.identifier.doi10.1038/s41588-019-0439-2
dc.identifier.issn1546-1718
dc.identifier.otherRIS: urn:123565FA4529F1D8A5292F1C10F0997E
dc.identifier.otherRIS: Watson2019
dc.identifier.otherMendeley: cfad2e01-8606-3e65-9c13-19162dc6bbc2
dc.identifier.otherORCID: /0000-0002-9154-426X/work/61767668
dc.identifier.urihttps://hdl.handle.net/2164/13518
dc.identifier.urlhttp://www.nature.com/articles/s41588-019-0439-2en
dc.identifier.urlhttp://www.mendeley.com/research/genomewide-association-study-identifies-eight-risk-loci-implicates-metabopsychiatric-origins-anorexien
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068455956&partnerID=8YFLogxKen
dc.identifier.vol51en
dc.language.isoeng
dc.relation.ispartofNature Geneticsen
dc.subjectLD SCORE REGRESSIONen
dc.subjectEATING-DISORDERSen
dc.subjectGENETIC CORRELATIONSen
dc.subjectPOLYGENIC RISKen
dc.subjectCOMORBIDITYen
dc.subjectPREVALENCEen
dc.subjectHERITABILITYen
dc.subjectVARIANTSen
dc.subjectINSIGHTSen
dc.subjectMYCen
dc.subjectQH426 Geneticsen
dc.subjectGeneticsen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectWellcome Trusten
dc.subjectSupplementary Dataen
dc.subject.lccQH426en
dc.titleGenome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosaen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
Watson_et_al_2019_Nature_Genetics_Manuscript_Combined_File_AAM.pdf
Size:
7.17 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Watson_et_al._2019_Supplementary_Tables.xlsx
Size:
2.42 MB
Format:
Unknown data format
Download

Collections

All research