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TAPBPR bridges UDP-glucose : glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

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dc.contributor.authorNeerincx, Andreas
dc.contributor.authorHermann, Clemens
dc.contributor.authorAntrobus, Robin
dc.contributor.authorvan Hateren, Andy
dc.contributor.authorCao, Huan
dc.contributor.authorTrautwein, Nico
dc.contributor.authorStevanović, Stefan
dc.contributor.authorElliott, Tim
dc.contributor.authorDeane, Janet E.
dc.contributor.authorBoyle, Louise H.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2017-06-07T14:12:59Z
dc.date.available2017-06-07T14:12:59Z
dc.date.issued2017-04-20
dc.descriptionFunding Wellcome: Senior Research Fellowship 104647, Andreas Neerincx, Louise H Boyle Royal Society: University Research Fellowship, UF100371, Janet E Deane Cancer Research UK: Programme Grant, C7056A, Andy van Hateren, Tim Elliott Deutsche Forschungsgemeinschaft: SFB 685, Nico Trautwein, Stefan Stevanović Wellcome: PhD studentship, 089563, Clemens Hermann Wellcome: Strategic Award 100140, Robin Antrobus Wellcome: Programme grant, WT094847MA, Huan Cao Acknowledgements We are extremely grateful to Peter Cresswell and Najla Arshad (Yale University School of Medicine, New Haven, CT) for valuable advice, tapasin and TAP-specific antibody reagents, and the recombinant calreticulin proteins. We thank John Trowsdale (University of Cambridge, UK) for his mentorship and critical reading of this manuscript, and Jim Kaufman (University of Cambridge, UK) for useful discussions. We also thank Yi Cao (Cranfield University, UK) for MATLAB programming for densitometry analysis, and Mark Vickers and Sadie Henderson (Scottish National Blood Transfusion Services, UK) for permitting the use of and assistance with the Amersham WB system. The reagent ARP7099 FEC peptide pool was obtained from the Centre for AIDS Reagents, National Institute for Biological Standards and Control (NIBSC), and was donated by the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH.en
dc.description.statusPeer revieweden
dc.format.extent25
dc.format.extent1936505
dc.identifier100725838
dc.identifierc1dbe886-f827-47ea-8fe0-629680aaa350
dc.identifier28425917
dc.identifier85019455454
dc.identifier.citationNeerincx, A, Hermann, C, Antrobus, R, van Hateren, A, Cao, H, Trautwein, N, Stevanović, S, Elliott, T, Deane, J E & Boyle, L H 2017, 'TAPBPR bridges UDP-glucose : glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway', eLife, vol. 6, e23049, pp. 1-25. https://doi.org/10.7554/eLife.23049en
dc.identifier.doi10.7554/eLife.23049
dc.identifier.urihttp://hdl.handle.net/2164/8767
dc.identifier.vol6en
dc.language.isoeng
dc.relation.ispartofeLifeen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicine (General)en
dc.subjectWellcome Trusten
dc.subject104647en
dc.subject089563en
dc.subject100140en
dc.subjectWT094847MAen
dc.subjectCancer Research UKen
dc.subjectC7056Aen
dc.subject.lccR1en
dc.titleTAPBPR bridges UDP-glucose : glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathwayen
dc.typeJournal articleen

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