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Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase

dc.contributor.authorWang, Shan
dc.contributor.authorBrittain, William D.G.
dc.contributor.authorZhang, Qian
dc.contributor.authorLu, Zhou
dc.contributor.authorTong, Ming Him
dc.contributor.authorWu, Kewen
dc.contributor.authorKyeremeh, Kwaku
dc.contributor.authorJenner, Matthew
dc.contributor.authorYu, Yi
dc.contributor.authorCobb, Steven L.
dc.contributor.authorDeng, Hai
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Natural & Computing Sciencesen
dc.date.accessioned2022-01-25T11:51:01Z
dc.date.available2022-01-25T11:51:01Z
dc.date.issued2022-01-10
dc.descriptionFunding Information: This work was supported by the Biotechnology and Biological Sciences Research Council UK (S.W. and H.D., BB/P00380X/1 and BB/R00479X/1, W.B. and S.L.C., BB/P003656/1). S.W and H.D. are grateful for SFC Covid-19 Grant extension and bridging Fund and UKRI Covid-19 Extension Allocation Fund. Q.Z. and Y.Y. are grateful for financial support from the National Key Research and Development Program of China (2018YFA0900400), the National Natural Science Foundation of China (31570033, 31811530299, and 31870035 to Y.Y.). H.D. and Y.Y. are recipients of a Royal Society-NSFC Newton Mobility Grant Award (IEC\NSFC\170617). M.J. is the recipient of a BBSRC Discovery Fellowship (BB/R012121/1). The Bruker MaXis II instrument used in this study was funded by the BBSRC (BB/M017982/1). K.K. and H.D. thank Leverhulme Trust-Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council-UK Department for International Development (MRC/DFID) Concordat agreement African Research Leaders Award (MR/S00520X/1). Publisher Copyright: © 2022, The Author(s).en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent2052949
dc.identifier212270068
dc.identifierbf0215bc-8503-45de-828d-d3481870aa35
dc.identifier85122862316
dc.identifier.citationWang, S, Brittain, W D G, Zhang, Q, Lu, Z, Tong, M H, Wu, K, Kyeremeh, K, Jenner, M, Yu, Y, Cobb, S L & Deng, H 2022, 'Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase', Nature Communications, vol. 13, no. 1, 62. https://doi.org/10.1038/s41467-021-27512-0en
dc.identifier.doi10.1038/s41467-021-27512-0
dc.identifier.iss1en
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0002-0047-0622/work/159509095
dc.identifier.urihttps://hdl.handle.net/2164/17974
dc.identifier.vol13en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectBiosynthesisen
dc.subjectEnzyme mechanismsen
dc.subjectEnzymesen
dc.subjectQD Chemistryen
dc.subjectQA76 Computer softwareen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Physics and Astronomyen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/P00380X/1en
dc.subjectBB/R00479X/1en
dc.subjectBB/P003656/1en
dc.subjectBB/R012121/1en
dc.subjectBB/M017982/1en
dc.subjectOtheren
dc.subjectIEC\NSFC\170617en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/S00520X/1en
dc.subject.lccQDen
dc.subject.lccQA76en
dc.titleAminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetaseen
dc.typeJournal articleen

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