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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

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dc.contributor.authorCosta, Alessia
dc.contributor.authorAi, Minrong
dc.contributor.authorNunn, Nicolas
dc.contributor.authorCulotta, Isabella
dc.contributor.authorHunter, Jenna
dc.contributor.authorBoudjadja, Mehdi Boutagouga
dc.contributor.authorValencia-Torres, Lourdes
dc.contributor.authorAviello, Gabriella
dc.contributor.authorHodson, David J.
dc.contributor.authorSnider, Brandy M.
dc.contributor.authorCoskun, Tamer
dc.contributor.authorEmmerson, Paul J.
dc.contributor.authorLuckman, Simon M.
dc.contributor.authorD'Agostino, Giuseppe
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2022-03-07T16:03:01Z
dc.date.available2022-03-07T16:03:01Z
dc.date.issued2022-01-01
dc.descriptionThis work was funded by an MRC Career Development Award (MR/ P009824/1 and MR/P009824/2) to GD’A, as well as an MRC grant to SML/GD’A (MR/T032669/1), a BBSRC grant to SML (BB/M001067/1), and an additional direct contribution from Eli Lilly. D.J.H. was sup- ported by MRC (MR/N00275X/1 and MR/S025618/1), Diabetes UK (17/ 0005681), and the European Research Council (ERC) under the Eu- ropean Union’s Horizon 2020 research and innovation programme (Starting Grant 715884 to D.J.H.). AC was supported for part of this project by a travel grant from the Italian Society of Pharmacology and a fellowship from the Veronesi Foundation (Italy).en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent2456956
dc.identifier214422060
dc.identifier31c7d7bf-233c-48be-b4f4-ca6a8c184ca7
dc.identifier85121225546
dc.identifier.citationCosta, A, Ai, M, Nunn, N, Culotta, I, Hunter, J, Boudjadja, M B, Valencia-Torres, L, Aviello, G, Hodson, D J, Snider, B M, Coskun, T, Emmerson, P J, Luckman, S M & D'Agostino, G 2022, 'Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation', Molecular Metabolism, vol. 55, pp. 101407. https://doi.org/10.1016/j.molmet.2021.101407en
dc.identifier.doi10.1016/j.molmet.2021.101407
dc.identifier.issn2212-8778
dc.identifier.otherBibtex: COSTA2022101407
dc.identifier.urihttps://hdl.handle.net/2164/18168
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2212877821002659en
dc.identifier.vol55en
dc.language.isoeng
dc.relation.ispartofMolecular Metabolismen
dc.subjectBrainen
dc.subjectAppetiteen
dc.subjectNauseaen
dc.subjectGlucagon-like peptide-1en
dc.subjectGlucose-dependent insulinotropic polypeptideen
dc.subjectCholecystokininen
dc.subjectArea postremaen
dc.subjectNucleus of the solitary tracten
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/ P009824/1en
dc.subjectMR/P009824/2en
dc.subjectMR/T032669/1en
dc.subjectMR/N00275X/1en
dc.subjectMR/S025618/1en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/M001067/1en
dc.subjectOtheren
dc.subjectEuropean Commissionen
dc.subject715884en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAnorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activationen
dc.typeJournal articleen

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