University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

Simple item page
dc.contributor.authorSingh, Abhay Narayan
dc.contributor.authorOehler, Judith
dc.contributor.authorTorrecilla, Ignacio
dc.contributor.authorKilgas, Susan
dc.contributor.authorLi, Shudong
dc.contributor.authorVaz, Bruno
dc.contributor.authorGuérillon, Claire
dc.contributor.authorFielden, John
dc.contributor.authorHernandez-Carralero, Esperanza
dc.contributor.authorCabrera, Elisa
dc.contributor.authorTullis, Iain D.C.
dc.contributor.authorMeerang, Mayura
dc.contributor.authorBarber, Paul R.
dc.contributor.authorFreire, Raimundo
dc.contributor.authorParsons, Jason
dc.contributor.authorVojnovic, Borivoj
dc.contributor.authorKiltie, Anne E.
dc.contributor.authorMailand, Niels
dc.contributor.authorRamadan, Kristijan
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2024-04-15T12:46:02Z
dc.date.available2024-04-15T12:46:02Z
dc.date.issued2019-11-04
dc.descriptionFunding Information: The Ramadan Laboratory is supported by a Medical Research Council UK programme grant (MC_EX_MR/K022830/1) to K.R. J.O. was supported by a Swiss National Science Foundation grant (31003A_141197) to K.R., a Goodger and Schorstein Scholarship, University of Oxford, and a European Institute of Innovation and Technology short-term post-doctoral fellowship. S. K, J. F. and S. L were supported by the Cancer Research UK or MRC studentships. B. Vo., A. E. K. and I. D. C. T. are supported by Cancer Research UK Programme Grant C5255/A15935. C.G. was supported by the Danish Cancer Society (Grant No. R146-RP11394). R. F. is supported by Spanish Ministry of Innovation Science and Universities/EU-ERDF (SAF2016-80626-R), E. C. is supported by the Fundaci?n DISA, and E. H-C. is supported by an ACIISI pre-doctoral fellowship. We thank Ross Chapman for providing us with WT and 53BP1-deficient MCF7 cell lines. We are grateful to Pam Reynolds for support with the UV micro-irradiation system, to the Mechanical and Electronics Workshops (J Prentice and RG Newman) for assistance with construction of the system, to the Bioanalysis Core (Graham Brown and Ioland Vendrell) for the supports with microscopy and mass spectrometry and to the Radiation Biophysics Core for the help with X-ray radiation. We thank Benedikt Kessler for his constant support with mass spectrometry. We thank Jeremy Stark for providing us with GFP-reporter assays for HR and NHEJ.en
dc.description.statusPeer revieweden
dc.format.extent25
dc.format.extent7686636
dc.identifier195022975
dc.identifiercb1a0698-0557-483f-b6c2-2f2c07f178c4
dc.identifier85074272876
dc.identifier31613024
dc.identifier.citationSingh, A N, Oehler, J, Torrecilla, I, Kilgas, S, Li, S, Vaz, B, Guérillon, C, Fielden, J, Hernandez-Carralero, E, Cabrera, E, Tullis, I D C, Meerang, M, Barber, P R, Freire, R, Parsons, J, Vojnovic, B, Kiltie, A E, Mailand, N & Ramadan, K 2019, 'The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8', EMBO Journal, vol. 38, no. 21, e102361. https://doi.org/10.15252/embj.2019102361en
dc.identifier.doi10.15252/embj.2019102361
dc.identifier.iss21en
dc.identifier.issn0261-4189
dc.identifier.otherORCID: /0000-0001-7208-2912/work/114166765
dc.identifier.urihttps://hdl.handle.net/2164/23241
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85074272876&partnerID=8YFLogxKen
dc.identifier.vol38en
dc.language.isoeng
dc.relation.ispartofEMBO Journalen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAtaxin 3en
dc.subjectDNA double-strand break repairen
dc.subjectE3 ubiquitin ligase RNF8en
dc.subjectgenome stabilityen
dc.subjectp97/VCP ATPaseen
dc.subjectR Medicineen
dc.subjectGeneral Neuroscienceen
dc.subjectMolecular Biologyen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Immunology and Microbiologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_EX_MR/K022830/1en
dc.subjectCancer Research UKen
dc.subjectC5255/A15935en
dc.subject.lccRen
dc.titleThe p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8en
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Singh_etal_EJ_p97-ataxin-3complex_VOR.pdf
Size:
7.33 MB
Format:
Adobe Portable Document Format
Download

Collections

All research