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Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression

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dc.contributor.authorRupprechter, Samuel
dc.contributor.authorRomaniuk, Liana
dc.contributor.authorSeries, Peggy
dc.contributor.authorHirose, Takehiro
dc.contributor.authorHawkins, Emma
dc.contributor.authorSandu-Giuraniuc, Anca-Larisa
dc.contributor.authorWaiter, Gordon D
dc.contributor.authorMcNeil, Christopher J
dc.contributor.authorShen, Xueyi
dc.contributor.authorHarris, Mathew A.
dc.contributor.authorCampbell, Archie
dc.contributor.authorPorteous, David
dc.contributor.authorMacfarlane, Jennifer A.
dc.contributor.authorLawrie, Stephen M.
dc.contributor.authorMurray, Alison D
dc.contributor.authorDelgado, Mauricio R
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorWhalley, Heather C.
dc.contributor.authorSteele, J Douglas
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2020-05-22T14:25:01Z
dc.date.available2020-05-22T14:25:01Z
dc.date.issued2020-06-01
dc.descriptionStratifying Resilience and Depression Longitudinally (STRADL) was supported by the Wellcome Trust through a Strategic Award (Grant No. 104036/Z/14/Z). Parts of the work were supported by a China Scholarship Council (Grant No. 201506040037 to SX), National Institutes of Health (Grant No. DA027764 to MRD), Lister Institute Prize Fellowship 2016–2021 (to DJS), Dr Mortimer and Theresa Sackler Foundation (AMM, HCW, and SML), Centre for Cognitive Ageing and Cognitive Epidemiology (IJD and AMM), Medical Research Council and Biotechnology and Biological Sciences Research Council (Grant No. MR/K026992/1), Royal College of Physicians of Edinburgh John, Margaret, Alfred and Stewart Sim fellowship (to HCW), and University of Edinburgh, Edinburgh Scientific Academic TmPCk College Fellowship (to HCW). The Chief Scientist Office of the Scottish Government Health Department (Grant No. CZD/16/6) and Scottish Funding Council (Grant No. HR03006) provided core support for Generation Scotland. Data acquisition was additionally supported by the Scottish Mental Health Research Network and Scottish Government’s Support for Science initiative. LR, HCW, and AMM, received financial support from Pfizer (formerly Wyeth) in relation to imaging studies of people with schizophrenia and bipolar disorder. AMM has previously received grant support from Lilly and Janssen. SML has received honoraria for lectures, chairing meetings, and consultancy work from Janssen in connection with brain imaging and therapeutic initiatives for psychosis. JDS has received funding via an honorarium associated with a lecture or Wyeth and funding from Indivior for a study on opioid dependency. No other disclosures were reported. The authors declare no conflict of interest.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent841205
dc.identifier156790385
dc.identifier87ae94a5-5c2c-4f6f-b0b4-b909a6ff06c9
dc.identifier32385498
dc.identifier85086682141
dc.identifier.citationRupprechter, S, Romaniuk, L, Series, P, Hirose, T, Hawkins, E, Sandu-Giuraniuc, A-L, Waiter, G D, McNeil, C J, Shen, X, Harris, M A, Campbell, A, Porteous, D, Macfarlane, J A, Lawrie, S M, Murray, A D, Delgado, M R, McIntosh, A M, Whalley, H C & Steele, J D 2020, 'Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression', Brain, vol. 143, no. 6, pp. 1946-1956. https://doi.org/10.1093/brain/awaa106en
dc.identifier.doi10.1093/brain/awaa106
dc.identifier.iss6en
dc.identifier.issn0006-8950
dc.identifier.otherORCID: /0000-0002-5313-9845/work/74712221
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976578
dc.identifier.otherORCID: /0000-0002-5555-4129/work/79062148
dc.identifier.urihttps://hdl.handle.net/2164/14354
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85086682141&partnerID=8YFLogxKen
dc.identifier.vol143en
dc.language.isoeng
dc.relation.ispartofBrainen
dc.subjectRDoCen
dc.subjecteffective connectivityen
dc.subjectreinforcement learningen
dc.subjectmodel-based fMRIen
dc.subjectreward prediction erroren
dc.subjectMDDen
dc.subjectDCMen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectClinical Neurologyen
dc.subjectScottish Funding Councilen
dc.subjectCZD/16/6en
dc.subjectHR03006en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K026992/1en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectDA027764en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subject201506040037en
dc.subject.lccRC0321en
dc.titleBlunted medial prefrontal cortico-limbic reward-related effective connectivity and depressionen
dc.typeJournal articleen

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