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The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

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dc.contributor.authorWatts, Lotte P
dc.contributor.authorNatsume, Toyoaki
dc.contributor.authorSaito, Yuichiro
dc.contributor.authorGarzon, Javier
dc.contributor.authorDong, Qianqian
dc.contributor.authorBoteva, Lora
dc.contributor.authorGilbert, Nick
dc.contributor.authorKanemaki, Masato T
dc.contributor.authorHiraga, Shin-Ichiro
dc.contributor.authorDonaldson, Anne D
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2021-04-12T14:25:01Z
dc.date.available2021-04-12T14:25:01Z
dc.date.issued2020-11-03
dc.descriptionAcknowledgements Thanks to members of the Aberdeen Chromosome Biology Group for helpful comments, and Ronan Broderick and Wojciech Niedzwiedz for advice on mitotic bridge analysis. We thank Raif Yuecel and his team at the Iain Fraser Cytometry Centre for assistance, and Kevin Mackenzie and his team at the Microscopy and Histology Core Facility. Work was supported by Cancer Research UK Studentship Award C1445/A20596 and CRUK Programme Award C1445/A19059; by JSPS KAKENHI Grants Numbers 17K15068, 18H02170 and 18H04719; by research grants from the Daiichi Sankyo’s Foundation of Life Science and the Takeda Science Foundation; and by the UK Medical Research Council (MC_UU_00007/13). Collaboration was supported by a 2017 JSPS Summer Programme Fellowship. Funding Cancer Research UK (C1445/A20596) Anne D Donaldson Cancer Research UK (C1445/A19059) Anne D Donaldson Japan Society for the Promotion of Science (17K15068) Masato T Kanemaki Japan Society for the Promotion of Science (18H02170) Masato T Kanemaki Japan Society for the Promotion of Science (18H04719) Masato T Kanemaki Medical Research Council (MC_UU_00007/13) Nick Gilberten
dc.description.statusPeer revieweden
dc.format.extent26
dc.format.extent2452490
dc.identifier178980568
dc.identifierb1bd3421-f7fa-4b9e-9c14-cb04700ea0d4
dc.identifier33141022
dc.identifier33141022
dc.identifier85096362949
dc.identifier.citationWatts, L P, Natsume, T, Saito, Y, Garzon, J, Dong, Q, Boteva, L, Gilbert, N, Kanemaki, M T, Hiraga, S-I & Donaldson, A D 2020, 'The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress', eLife, vol. 9, e58020. https://doi.org/10.7554/eLife.58020en
dc.identifier.doi10.7554/eLife.58020
dc.identifier.otherORCID: /0000-0002-8722-3869/work/83310244
dc.identifier.otherORCID: /0000-0002-5093-8385/work/83311016
dc.identifier.otherunpaywall: 10.7554/elife.58020
dc.identifier.urihttps://hdl.handle.net/2164/16226
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85096362949&partnerID=8YFLogxKen
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofeLifeen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectRIF1en
dc.subjectDNA replicationen
dc.subjectDNA replication stressen
dc.subjectSplicingen
dc.subjectreplication stressen
dc.subjectcell biologyen
dc.subjectchromosomesen
dc.subjectsplicingen
dc.subjecthumanen
dc.subjectgene expressionen
dc.subjectR Medicineen
dc.subjectGeneral Immunology and Microbiologyen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Neuroscienceen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_00007/13en
dc.subjectCancer Research UKen
dc.subjectC1445/A20596en
dc.subjectC1445/A19059en
dc.subject.lccRen
dc.titleThe RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stressen
dc.typeJournal articleen

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