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Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes

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dc.contributor.authorMazzon, Michela
dc.contributor.authorCastro, Cecilia
dc.contributor.authorThaa, Bastian
dc.contributor.authorLiu, Lifeng
dc.contributor.authorMutso, Margit
dc.contributor.authorLiu, Xiang
dc.contributor.authorMahalingam, Suresh
dc.contributor.authorGriffin, Julian L
dc.contributor.authorMarsh, Mark
dc.contributor.authorMcInerney, Gerald M
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2021-11-26T10:34:01Z
dc.date.available2021-11-26T10:34:01Z
dc.date.issued2018-01-29
dc.descriptionAcknowledgments We thank our MRC-LMCB colleagues Dr Chiara Mencarelli who provided the rat cortical neurons used in this study, Dr Christin Luft for help with acquisition of high-content confocal images, and Dr Janos Kriston-Vizi for help with Fiji software. Dr Scott Lawrence kindly provided the SH-SY5Y cells. We thank Prof Andres Merits (University of Tartu, Estonia) for provision of nsP3 antibody and Dr Ji Luo (National Cancer Institute, USA) for provision of p85 expression plasmids.en
dc.description.statusPeer revieweden
dc.format.extent22
dc.format.extent9281737
dc.identifier197054477
dc.identifier5b033bae-e5be-4059-8d0c-9a4a76347536
dc.identifier29377936
dc.identifier85041678829
dc.identifier.citationMazzon, M, Castro, C, Thaa, B, Liu, L, Mutso, M, Liu, X, Mahalingam, S, Griffin, J L, Marsh, M & McInerney, G M 2018, 'Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes', PLoS Pathogens, vol. 14, no. 1, e1006835. https://doi.org/10.1371/journal.ppat.1006835en
dc.identifier.doi10.1371/journal.ppat.1006835
dc.identifier.iss1en
dc.identifier.issn1553-7366
dc.identifier.otherPubMedCentral: PMC5805360
dc.identifier.otherORCID: /0000-0003-1336-7744/work/98038723
dc.identifier.urihttps://hdl.handle.net/2164/17568
dc.identifier.vol14en
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.subjectAlphavirus/pathogenicityen
dc.subjectAlphavirus Infections/metabolismen
dc.subjectAnimalsen
dc.subjectCells, Cultureden
dc.subjectCricetinaeen
dc.subjectEnzyme Activationen
dc.subjectGlucose/metabolismen
dc.subjectGlycolysis/physiologyen
dc.subjectHEK293 Cellsen
dc.subjectHost-Pathogen Interactionsen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred C57BLen
dc.subjectPhosphatidylinositol 3-Kinases/metabolismen
dc.subjectProto-Oncogene Proteins c-akt/metabolismen
dc.subjectRoss River virus/physiologyen
dc.subjectSemliki forest virus/physiologyen
dc.subjectVirulenceen
dc.subjectQR355 Virologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_12018/1en
dc.subjectMC_UP_A090_1006en
dc.subjectSupplementary Informationen
dc.subject.lccQR355en
dc.titleAlphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changesen
dc.typeJournal articleen

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