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Hypoxia Promotes Immune Evasion by Triggering β-glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling

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dc.contributor.authorPradhan, Arnab
dc.contributor.authorAvelar, Gabriela M.
dc.contributor.authorBain, Judith M.
dc.contributor.authorChilders, Delma S
dc.contributor.authorLarcombe, Daniel E.
dc.contributor.authorNetea, Mihai G.
dc.contributor.authorShekhova, Elena
dc.contributor.authorMunro, Carol A.
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorErwig, Lars P.
dc.contributor.authorGow, Neil A. R.
dc.contributor.authorBrown, Alistair J. P.
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.date.accessioned2018-11-09T10:10:06Z
dc.date.available2018-11-09T10:10:06Z
dc.date.issued2018-11-06
dc.descriptionWe are very grateful to the members of our Iain Fraser Cytometry Centre and Microscopy and Histology Core Facility for their superb help, advice and support. We also thank our generous colleagues in the Candida community, and in particular Ana Traven, Jan Quinn, Guanghua Huang, Suzanne Noble, Donna MacCallum, Liz Johnson, Karl Kuchler, Patrick van Dijck, Rich Calderone and Malcolm Whiteway for providing strains used in this study. This work was funded by grants from the UK Medical Research Council [www.mrc.ac.uk], to AJPB, NARG, LPE, MN (MR/M026663/1), and by PhD studentships from the University of Aberdeen to AP, DL. The work was also supported by the Wellcome Trust [www.wellcome.ac.uk], NARG, GDB, AJPB (097377) and GDB (102705); and by the Medical Research Council Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent18
dc.format.extent4285442
dc.identifier130181262
dc.identifiereca21f98-174c-4a05-958b-420d24cee643
dc.identifier85056251699
dc.identifier30401773
dc.identifier.citationPradhan, A, Avelar, G M, Bain, J M, Childers, D S, Larcombe, D E, Netea, M G, Shekhova, E, Munro, C A, Brown, G D, Erwig, L P, Gow, N A R & Brown, A J P 2018, 'Hypoxia Promotes Immune Evasion by Triggering β-glucan Masking on the Candida albicans  Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling', mBio, vol. 9, e01318-18. https://doi.org/10.1128/mBio.01318-18en
dc.identifier.doi10.1128/mBio.01318-18
dc.identifier.otherORCID: /0000-0002-2776-5850/work/52609430
dc.identifier.otherORCID: /0000-0003-2869-7332/work/76975989
dc.identifier.otherORCID: /0000-0002-1060-0419/work/112075856
dc.identifier.otherORCID: /0000-0003-0761-1755/work/162729079
dc.identifier.urihttp://hdl.handle.net/2164/11411
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofmBioen
dc.subjecthypoxiaen
dc.subjectCandida albicansen
dc.subjectcell wallen
dc.subjectβ-glucan maskingen
dc.subjectmitochondrial signallingen
dc.subjectcAMP-protein kinase A signallingen
dc.subjectR Medicine (General)en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/M026663/1en
dc.subjectMR/N006364/1en
dc.subjectWellcome Trusten
dc.subject097377en
dc.subject102705en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleHypoxia Promotes Immune Evasion by Triggering β-glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signalingen
dc.typeJournal articleen

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