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Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

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dc.contributor.authorTesta, Andrea
dc.contributor.authorDall'Angelo, Sergio
dc.contributor.authorMingarelli, Marco
dc.contributor.authorAugello, Andrea
dc.contributor.authorSchweiger, Lutz
dc.contributor.authorWelch, Andrew Edward
dc.contributor.authorElmore, Charles S.
dc.contributor.authorSharma, Pradeep
dc.contributor.authorZanda, Matteo
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2017-12-10T00:01:50Z
dc.date.available2017-12-10T00:01:50Z
dc.date.embargoedUntil2017-12-09
dc.date.issued2017-02-01
dc.descriptionWe thank Dr Dana Dawson and Dr Gabriella Baio for support and advice with PET imaging experiments. A.T. gratefully acknowledges SINAPSE (www.sinapse.ac.uk) and AstraZeneca (UK) for co-funding a studentship. P.S. and C.S.E. are employees of AstraZeneca Ltd., UK.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent2282717
dc.identifier74187875
dc.identifier67f4b510-06dd-4cac-a01a-5074ea23864b
dc.identifier85008192331
dc.identifier.citationTesta, A, Dall'Angelo, S, Mingarelli, M, Augello, A, Schweiger, L, Welch, A E, Elmore, C S, Sharma, P & Zanda, M 2017, 'Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters', Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976. https://doi.org/10.1016/j.bmc.2016.12.008en
dc.identifier.doi10.1016/j.bmc.2016.12.008
dc.identifier.iss3en
dc.identifier.issn0968-0896
dc.identifier.otherORCID: /0000-0001-9377-0474/work/176747535
dc.identifier.urihttp://hdl.handle.net/2164/9754
dc.identifier.vol25en
dc.language.isoeng
dc.relation.ispartofBioorganic & Medicinal Chemistryen
dc.subjectfluorineen
dc.subjectbile acidsen
dc.subjectliver transportersen
dc.subjectPET imagingen
dc.subjecttritiumen
dc.subjectpreclinical studyen
dc.subjectclick chemistryen
dc.subjectclearanceen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleDesign, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transportersen
dc.typeJournal articleen

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