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An inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosis

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dc.contributor.authorMorris, Derek W.
dc.contributor.authorPearson, Richard D.
dc.contributor.authorCormican, Paul
dc.contributor.authorKenny, Elaine M.
dc.contributor.authorO'Dushlaine, Colm T.
dc.contributor.authorPerreault, Louis Philippe Lemieux
dc.contributor.authorGiannoulatou, Eleni
dc.contributor.authorTropea, Daniela
dc.contributor.authorMaher, Brion S.
dc.contributor.authorWormley, Brandon
dc.contributor.authorKelleher, Eric
dc.contributor.authorFahey, Ciara
dc.contributor.authorMolinos, Ines
dc.contributor.authorBellini, Stefania
dc.contributor.authorPirinen, Matti
dc.contributor.authorStrange, Amy
dc.contributor.authorFreeman, Colin
dc.contributor.authorThiselton, Dawn L.
dc.contributor.authorElves, Rachel L.
dc.contributor.authorRegan, Regina
dc.contributor.authorEnnis, Sean
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMurphy, Kieran C.
dc.contributor.authorO'Callaghan, Eadbhard
dc.contributor.authorWaddington, John L.
dc.contributor.authorWalsh, Dermot
dc.contributor.authorO'Donovan, Michael
dc.contributor.authorGrozeva, Detelina
dc.contributor.authorCraddock, Nick
dc.contributor.authorStone, Jennifer
dc.contributor.authorScolnick, Ed
dc.contributor.authorPurcell, Shaun
dc.contributor.authorSklar, Pamela
dc.contributor.authorCoe, Bradley
dc.contributor.authorEichler, Evan E.
dc.contributor.authorOphoff, Roel
dc.contributor.authorBuizer, Jacobine
dc.contributor.authorSzatkiewicz, Jin
dc.contributor.authorHultman, Christina
dc.contributor.authorSullivan, Patrick
dc.contributor.authorGurling, Hugh
dc.contributor.authorMcquillin, Andrew
dc.contributor.authorSt Clair, David
dc.contributor.authorRees, Elliott
dc.contributor.authorKirov, George
dc.contributor.authorWalters, James
dc.contributor.authorBlackwood, Douglas
dc.contributor.authorJohnstone, Mandy
dc.contributor.authorDonohoe, Gary
dc.contributor.authorThe International Schizophrenia Consortium (ISC)
dc.contributor.authorSGENE+ Consortium
dc.contributor.authorO'Neill, Francis A.
dc.contributor.authorThe Wellcome Trust Case Control Consortium 2 (WTCCC2)
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorGill, Michael
dc.contributor.authorRiley, Brien P.
dc.contributor.authorSpencer, Chris C. A.
dc.contributor.authorCorvin, Aiden
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2018-12-04T13:00:08Z
dc.date.available2018-12-04T13:00:08Z
dc.date.issued2014-06-15
dc.descriptionFUNDING Funding for this study was provided by the Wellcome Trust Case Control Consortium 2 project (085475/B/08/Z and 085475/Z/08/Z), the Wellcome Trust (072894/Z/03/Z, 090532/Z/09/Z and 075491/Z/04/B), NIMH grants (MH 41953 and MH083094) and Science Foundation Ireland (08/IN.1/B1916). We acknowledge use of the Trinity Biobank sample from the Irish Blood Transfusion Service; the Trinity Centre for High Performance Computing; British 1958 Birth Cohort DNA collection funded by the Medical Research Council (G0000934) and the Wellcome Trust (068545/Z/02) and of the UK National Blood Service controls funded by the Wellcome Trust. Chris Spencer is supported by a Wellcome Trust Career Development Fellowship (097364/Z/11/Z). Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust. ACKNOWLEDGEMENTS The authors sincerely thank all patients who contributed to this study and all staff who facilitated their involvement. We thank W. Bodmer and B. Winney for use of the People of the British Isles DNA collection, which was funded by the Wellcome Trust. We thank Akira Sawa and Koko Ishzuki for advice on the PAK7–DISC1 interaction experiment and Jan Korbel for discussions on mechanism of structural variation.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent884172
dc.identifier140589420
dc.identifierbc12dc5d-a72c-4fec-b2d3-9e3e4fdc9507
dc.identifier84901324489
dc.identifier24474471
dc.identifier.citationMorris, D W, Pearson, R D, Cormican, P, Kenny, E M, O'Dushlaine, C T, Perreault, L P L, Giannoulatou, E, Tropea, D, Maher, B S, Wormley, B, Kelleher, E, Fahey, C, Molinos, I, Bellini, S, Pirinen, M, Strange, A, Freeman, C, Thiselton, D L, Elves, R L, Regan, R, Ennis, S, Dinan, T G, McDonald, C, Murphy, K C, O'Callaghan, E, Waddington, J L, Walsh, D, O'Donovan, M, Grozeva, D, Craddock, N, Stone, J, Scolnick, E, Purcell, S, Sklar, P, Coe, B, Eichler, E E, Ophoff, R, Buizer, J, Szatkiewicz, J, Hultman, C, Sullivan, P, Gurling, H, Mcquillin, A, St Clair, D, Rees, E, Kirov, G, Walters, J, Blackwood, D, Johnstone, M, Donohoe, G, The International Schizophrenia Consortium (ISC), SGENE+ Consortium, O'Neill, F A, The Wellcome Trust Case Control Consortium 2 (WTCCC2), Kendler, K S, Gill, M, Riley, B P, Spencer, C C A & Corvin, A 2014, 'An inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosis', Human Molecular Genetics, vol. 23, no. 12, pp. 3316-3326. https://doi.org/10.1093/hmg/ddu025en
dc.identifier.doi10.1093/hmg/ddu025
dc.identifier.iss12en
dc.identifier.issn0964-6906
dc.identifier.urihttp://hdl.handle.net/2164/11558
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84901324489&partnerID=8YFLogxKen
dc.identifier.vol23en
dc.language.isoeng
dc.relation.ispartofHuman Molecular Geneticsen
dc.subjectQH426 Geneticsen
dc.subjectMolecular Biologyen
dc.subjectGeneticsen
dc.subjectGenetics(clinical)en
dc.subjectWellcome Trusten
dc.subject085475/B/08/Zen
dc.subject085475/Z/08/Zen
dc.subject072894/Z/03/Zen
dc.subject090532/Z/09/Zen
dc.subject075491/Z/04/Ben
dc.subject068545/Z/02en
dc.subject097364/Z/11/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectG0000934en
dc.subject.lccQH426en
dc.titleAn inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosisen
dc.typeJournal articleen

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