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Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

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dc.contributor.authorLeach, Michelle D
dc.contributor.authorFarrer, Rhys A
dc.contributor.authorTan, Kaeling
dc.contributor.authorMiao, Zhengqiang
dc.contributor.authorWalker, Louise A
dc.contributor.authorCuomo, Christina A
dc.contributor.authorWheeler, Robert T
dc.contributor.authorBrown, Alistair J P
dc.contributor.authorWong, Koon Ho
dc.contributor.authorCowen, Leah E
dc.contributor.institutionUniversity of Aberdeen.Centre for Genome-Enabled Biology and Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2016-06-03T15:40:06Z
dc.date.available2016-06-03T15:40:06Z
dc.date.issued2016-05-26
dc.descriptionWe thank Karim Gharbi and Urmi Trivedi for their assistance with RNA sequencing, carried out in the GenePool genomics facility (University of Edinburgh). We also thank Susan Fairley and Eduardo De Paiva Alves (Centre for Genome Enabled Biology and Medicine, University of Aberdeen) for help with the initial bioinformatics analysis. We thank Aaron Mitchell for kindly providing the ALS3 mutant, Julian Naglik for the gift of TR146 cells, and Jon Richardson for technical assistance. We thank the Genomics and Bioinformatics core of the Faculty of Health Sciences for Next Generation Sequencing and Bioinformatics support, the Information and Communication Technology Office at the University of Macau for providing access to a High Performance Computer and Jacky Chan and William Pang for their expert support on the High Performance Computer. Finally, we thank Amanda Veri for generating CaLC2928. M.D.L. is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), R.A.F. by a Wellcome Trust-Massachusetts Institute of Technology (MIT) Postdoctoral Fellowship, L.E.C. by a Canada Research Chair in Microbial Genomics and Infectious Disease and by Canadian Institutes of Health Research Grants MOP-119520 and MOP-86452, A.J. P.B. was supported by the UK Biotechnology and Biological Sciences Research Council (BB/F00513X/1) and by the European Research Council (ERC-2009-AdG-249793-STRIFE), KHW is supported by the Science and Technology Development Fund of Macau S.A.R (FDCT) (085/2014/A2) and the Research and Development Administrative Office of the University of Macau (SRG2014-00003-FHS) and R.T.W. by the Burroughs Wellcome fund and NIH R15AO094406. Data availability RNA-sequencing data sets are available at ArrayExpress (www.ebi.ac.uk) under accession code E-MTAB-4075. ChIP-seq data sets are available at the NCBI SRA database (http://www.ncbi.nlm.nih.gov) under accession code SRP071687. The authors declare that all other data supporting the findings of this study are available within the article and its supplementary information files, or from the corresponding author upon request.en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent2808990
dc.identifier67655636
dc.identifierdacec85a-0b12-48c9-95b5-c183dbe47dbf
dc.identifier27226156
dc.identifier84971228926
dc.identifier.citationLeach, M D, Farrer, R A, Tan, K, Miao, Z, Walker, L A, Cuomo, C A, Wheeler, R T, Brown, A J P, Wong, K H & Cowen, L E 2016, 'Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans', Nature Communications, vol. 7, 11704. https://doi.org/10.1038/ncomms11704en
dc.identifier.doi10.1038/ncomms11704
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0001-8456-7458/work/50284165
dc.identifier.urihttp://hdl.handle.net/2164/6073
dc.identifier.vol7en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectQR Microbiologyen
dc.subjectWellcome Trusten
dc.subject096072en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/F00513X/1en
dc.subjectEuropean Research Councilen
dc.subjectERC-2009-AdG-249793-STRIFEen
dc.subjectSupplementary Dataen
dc.subject.lccQRen
dc.titleHsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicansen
dc.typeJournal articleen

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