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The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice

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dc.contributor.authorDekeryte, Ruta
dc.contributor.authorFranklin, Zara
dc.contributor.authorHull, Claire
dc.contributor.authorCroce, Lorenzo
dc.contributor.authorKamli-Salino, Sarah
dc.contributor.authorHelk, Oliver Walter
dc.contributor.authorHoffmann, Philip
dc.contributor.authorYang, Zhixiang
dc.contributor.authorRiedel, Gernot
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorPlatt, Bettina
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.contributor.institutionUniversity of Aberdeen.Vice Principalsen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2022-04-19T23:09:19Z
dc.date.available2022-04-19T23:09:19Z
dc.date.embargoedUntil2022-04-20
dc.date.issued2021-07-01
dc.descriptionAcknowledgements The authors would like to acknowledge University of Aberdeen PhD studentship to RD and Alzheimer’s Research UK grant to BP and MD (ARUK-PG2017B-11). The authors also thank David Riddell and David McKinzie at Eli Lilly for involvement with sample handling for Aβ determination.en
dc.description.statusPeer revieweden
dc.format.extent9
dc.format.extent508906
dc.identifier191555673
dc.identifier5f3e8356-0e7a-4da0-af42-d2a9fd613fd3
dc.identifier33892080
dc.identifier85105257273
dc.identifier000649764800015
dc.identifier000672317900014
dc.identifier000672317900014
dc.identifier000672317900014
dc.identifier.citationDekeryte, R, Franklin, Z, Hull, C, Croce, L, Kamli-Salino, S, Helk, O W, Hoffmann, P, Yang, Z, Riedel, G, Delibegovic, M & Platt, B 2021, 'The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice', Biochimica et Biophysica Acta. Molecular Basis of Disease : BBA , vol. 1867, no. 7, 166149. https://doi.org/10.1016/j.bbadis.2021.166149en
dc.identifier.doi10.1016/j.bbadis.2021.166149
dc.identifier.iss7en
dc.identifier.issn0925-4439
dc.identifier.otherORCID: /0000-0002-5107-5366/work/128760427
dc.identifier.otherORCID: /0000-0002-7852-0749/work/93483336
dc.identifier.otherORCID: /0000-0001-6685-5181/work/93483374
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847649
dc.identifier.otherORCID: /0000-0002-5107-5366/work/128760427
dc.identifier.urihttps://hdl.handle.net/2164/18450
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-85105257273&partnerID=MN8TOARSen
dc.language.isoeng
dc.relation.ispartofBiochimica et Biophysica Acta. Molecular Basis of Disease : BBAen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectADen
dc.subjectT2DMen
dc.subjectBACE1en
dc.subjectLY2886721en
dc.subjectBeta Amyloiden
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleThe BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in miceen
dc.typeJournal articleen

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