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Targeting a critical step in fungal hexosamine biosynthesis

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dc.contributor.authorLockhart, Deborah E. A.
dc.contributor.authorStanley, Mathew
dc.contributor.authorRaimi, Olawale G.
dc.contributor.authorRobinson, David A.
dc.contributor.authorBoldovjakova, Dominika
dc.contributor.authorSquair, Daniel R.
dc.contributor.authorFerenbach, Andrew T.
dc.contributor.authorFang, Wenxia
dc.contributor.authorvan Aalten, Daan M. F.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.date.accessioned2020-08-04T17:45:00Z
dc.date.available2020-08-04T17:45:00Z
dc.date.issued2020-06-26
dc.descriptionAcknowledgements We wish to thank the Dundee Drug Discovery Unit for access to the Fragment library and the European Synchrotron Radiation Facility, Grenoble and Diamond Light Source, Oxford for time at the beamline. The assistance from Mr Martin Kierans, School of Life Sciences, University of Dundee with the Electron Microscopy is gratefully acknowledged. Funding and additional information This work was supported by a Wellcome Trust Postdoctoral Research Training Fellowship for Clinicians (WT105772/A/14/Z) to DL and an MRC Programme Grant (MR/M004139/1) to DMFvA. DB was funded by a University of Aberdeen Summer Research Scholarship.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent1277607
dc.format.extent1516038
dc.identifier162160849
dc.identifier25f96062-6a8f-45c4-b076-af58550ac4cc
dc.identifier32341126
dc.identifier32341126
dc.identifier85087253752
dc.identifier000546296800005
dc.identifier.citationLockhart, D E A, Stanley, M, Raimi, O G, Robinson, D A, Boldovjakova, D, Squair, D R, Ferenbach, A T, Fang, W & van Aalten, D M F 2020, 'Targeting a critical step in fungal hexosamine biosynthesis', Journal of Biological Chemistry, vol. 295, no. 26, pp. 8678-8691. https://doi.org/10.1074/jbc.RA120.012985en
dc.identifier.doi10.1074/jbc.RA120.012985
dc.identifier.iss26en
dc.identifier.issn0021-9258
dc.identifier.otherORCID: /0000-0002-4262-3842/work/76974405
dc.identifier.urihttps://hdl.handle.net/2164/14861
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85087253752&partnerID=8YFLogxKen
dc.identifier.vol295en
dc.language.isoeng
dc.relation.ispartofJournal of Biological Chemistryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectfungien
dc.subjectAspergillus fumigatusen
dc.subjectcell wallen
dc.subjectglucosamine 6-phosphate N-acetyltransferase (Gna1)en
dc.subjectresistanceen
dc.subjectfragmenten
dc.subjectprotein-protein interactionen
dc.subjectvirulence factoren
dc.subjectchitinen
dc.subjectantifungal drug developmenten
dc.subjectX-ray crystallographyen
dc.subjectASPERGILLUS-FUMIGATUSen
dc.subjectPRACTICE GUIDELINESen
dc.subjectNIKKOMYCIN-Zen
dc.subjectSTRESS-RESPONSEen
dc.subjectSTRUCTURAL VALIDATIONen
dc.subjectMURINE MODELen
dc.subjectCELL-WALLen
dc.subjectGALLERIA-MELLONELLA LARVAEen
dc.subjectINHIBITORSen
dc.subjectINFECTIOUS-DISEASES SOCIETYen
dc.subjectQ Science (General)en
dc.subjectMolecular Biologyen
dc.subjectBiochemistryen
dc.subjectCell Biologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/M004139/1en
dc.subjectWellcome Trusten
dc.subjectWT105772/A/14/Zen
dc.subject.lccQ1en
dc.titleTargeting a critical step in fungal hexosamine biosynthesisen
dc.typeJournal articleen

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