University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Simple item page
dc.contributor.authorUbah, Obinna C.
dc.contributor.authorSteven, John
dc.contributor.authorPorter, Andrew J.
dc.contributor.authorBarelle, Caroline J.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2019-03-22T11:30:06Z
dc.date.available2019-03-22T11:30:06Z
dc.date.issued2019-03
dc.descriptionFunding The Biotechnology and Biological Sciences Research Council (BB/K010905/1), Scottish Enterprise (VNAR_001 (2012), Innovate UK (102865). Acknowledgments The authors wish to acknowledge the funding support for this work from Scottish Enterprise (SE), the Biotechnology and Biological Sciences Research Council (BBSRC), and Innovate UK.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent2663845
dc.identifier142500674
dc.identifier918010a8-54aa-4fca-8682-1a04e1402bd8
dc.identifier85064721344
dc.identifier000461990600001
dc.identifier.citationUbah, O C, Steven, J, Porter, A J & Barelle, C J 2019, 'An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model', Frontiers in Immunology, vol. 10, 526. https://doi.org/10.3389/fimmu.2019.00526en
dc.identifier.doi10.3389/fimmu.2019.00526
dc.identifier.issn1664-3224
dc.identifier.otherRIS: urn:F2D6899978E05B8509B07A2EE5FEBA44
dc.identifier.otherMendeley: 12816d3c-6ded-3da5-bca3-d680c2133405
dc.identifier.urihttp://hdl.handle.net/2164/12078
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85064721344&partnerID=8YFLogxKen
dc.identifier.urlhttps://www.frontiersin.org/article/10.3389/fimmu.2019.00526/fullen
dc.identifier.urlhttp://www.mendeley.com/research/antihtnf%CE%B1-variable-new-antigen-receptor-format-demonstrates-superior-vivo-preclinical-efficacy-humiren
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunologyen
dc.subjectvariable new antigen receptors (VNARs)en
dc.subjectchronic inflammationen
dc.subjectshark IgNARen
dc.subjectanti-TNF biologicsen
dc.subjectrheumatoid arthritisen
dc.subjectautoimmune diseaseen
dc.subjectTNF-alphaen
dc.subjectRHEUMATOID-ARTHRITISen
dc.subjectADALIMUMABen
dc.subjectTHERAPEUTIC ANTIBODIESen
dc.subjectKNOCKOUT MICEen
dc.subjectDOSE-ESCALATIONen
dc.subjectMURINE MODELen
dc.subjectIMMUNOGENICITYen
dc.subjectTUMOR-NECROSIS-FACTORen
dc.subjectTRANSMEMBRANE TNF-ALPHAen
dc.subjectMONOCLONAL-ANTIBODIESen
dc.subjectR Medicine (General)en
dc.subjectImmunology and Allergyen
dc.subjectImmunologyen
dc.subjectInnovate UKen
dc.subject102865en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K010905/1en
dc.subjectOtheren
dc.subjectVNAR_001 (2012)en
dc.subject.lccR1en
dc.titleAn Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Modelen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
fimmu_10_00526.pdf
Size:
2.54 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
8.31 KB
Format:
Plain Text
Description:
Download

Collections

All research
Medical Sciences research
University Office research