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N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

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dc.contributor.authorFang, Wenxia
dc.contributor.authorRaimi, Olawale G
dc.contributor.authorBlair, David E
dc.contributor.authorHarrison, Justin R
dc.contributor.authorLockhart, Deborah E A
dc.contributor.authorTorrie, Leah S
dc.contributor.authorRuda, Gian Filippo
dc.contributor.authorWyatt, Paul G
dc.contributor.authorGilbert, Ian H
dc.contributor.authorvan Aalten, Daan M F
dc.date.accessioned2021-02-02T14:25:01Z
dc.date.available2021-02-02T14:25:01Z
dc.date.issued2015-06-19
dc.descriptionThe authors would like to thank the European Synchrotron Radiation facility (ESRF), Grenoble, for beamline time. We thank J. James of the College of Life Sciences Microscopy Facility for his help with electron microscopy. We also thank F. Eisenhaber, Bioinformatics Institute Singapore, for predicting myristoylated proteins. This work was funded by an MRC Programme Grant (M004139) and a Wellcome Trust Senior Research Fellowship (WT087590MA) to D.M.F.v.A. D.E.A.L was supported by an MRC Clinical Research Training Fellowship (G1100430). We also would like to acknowledge the Wellcome Trust (WT077705, WT083481) for support. Supporting Figures S1−S3, Supporting Tables S1−S4, and further details of experimental procedures. This material is available free of charge via the Internet from http://pubs.acs.org.en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent2101069
dc.identifier114869526
dc.identifier8df26846-749e-46a2-b85a-e096f9dc47b7
dc.identifier25706802
dc.identifier84934947778
dc.identifier.citationFang, W, Raimi, O G, Blair, D E, Harrison, J R, Lockhart, D E A, Torrie, L S, Ruda, G F, Wyatt, P G, Gilbert, I H & van Aalten, D M F 2015, 'N -myristoyltransferase is a cell wall target in Aspergillus fumigatus', ACS Chemical Biology, vol. 10, no. 6, pp. 1425-1434. https://doi.org/10.1021/cb5008647en
dc.identifier.doi10.1021/cb5008647
dc.identifier.iss6en
dc.identifier.issn1554-8929
dc.identifier.otherPubMedCentral: PMC4477619
dc.identifier.otherORCID: /0000-0002-4262-3842/work/189632471
dc.identifier.urihttps://hdl.handle.net/2164/15765
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofACS Chemical Biologyen
dc.subjectAcyltransferasesen
dc.subjectAminopyridinesen
dc.subjectAntifungal Agentsen
dc.subjectAspergillus fumigatusen
dc.subjectCatalytic Domainen
dc.subjectCell Wallen
dc.subjectCrystallography, X-Rayen
dc.subjectFungal Proteinsen
dc.subjectKineticsen
dc.subjectMicrobial Sensitivity Testsen
dc.subjectProtein Bindingen
dc.subjectProtein Processing, Post-Translationalen
dc.subjectProtein Structure, Secondaryen
dc.subjectPyrazolesen
dc.subjectStructure-Activity Relationshipen
dc.subjectSulfonamidesen
dc.subjectJournal Articleen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectQD Chemistryen
dc.subjectMedical Research Council (MRC)en
dc.subjectM004139en
dc.subjectG1100430en
dc.subjectWellcome Trusten
dc.subjectWT087590MAen
dc.subjectWT077705en
dc.subjectWT083481en
dc.subjectSupplementary Dataen
dc.subject.lccQDen
dc.titleN-myristoyltransferase is a cell wall target in Aspergillus fumigatusen
dc.typeJournal articleen

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