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The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

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dc.contributor.authorMohamed, Abdalla
dc.contributor.authorSun, Congshan
dc.contributor.authorDe Mello, Vanessa
dc.contributor.authorSelfe, Joanna
dc.contributor.authorMissiaglia, Edoardo
dc.contributor.authorShipley, Janet
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorZammit, Pete S.
dc.contributor.authorWackerhage, Henning
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.East Bioen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2016-09-23T15:00:04Z
dc.date.available2016-09-23T15:00:04Z
dc.date.issued2016-09
dc.descriptionAcknowledgements This study was funded by Sarcoma UK, Friends of Anchor and the Medical Research Council grant number 99477 awarded to HW and PSZ. This work was also supported, in part, by NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden Hospital and the Institute of Cancer Research, and the Chris Lucas Trust, UK. We also thank the CCLG (Children's cancer and leukaemia group) Tissue Bank for access to samples, and contributing CCLG centres, including members of the ECMC paediatric network. The CCLG Tissue Bank is funded by Cancer Research UK and CCLG. The Zammit lab is also currently supported by Muscular Dystrophy UK (RA3-3052), Association Française Contre les Myopathies (17865, 20082, 19105 and 16050) and the FSH (Fascioscapulohumeral muscular dystrophy) Society (Shack Family and Friends research grant (FSHS-82013-06)). In addition, we would like to thank Prof Kun-Liang Guan and Prof Malcolm Logan for kindly providing constructs.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent5913901
dc.identifier65963588
dc.identifier2d033597-fb85-41a8-9edb-aadd5e132f8e
dc.identifier84983287800
dc.identifier.citationMohamed, A, Sun, C, De Mello, V, Selfe, J, Missiaglia, E, Shipley, J, Murray, G I, Zammit, P S & Wackerhage, H 2016, 'The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma', The Journal of pathology, vol. 240, no. 1, pp. 3-14. https://doi.org/10.1002/path.4745en
dc.identifier.doi10.1002/path.4745
dc.identifier.iss1en
dc.identifier.issn0022-3417
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973508
dc.identifier.urihttp://hdl.handle.net/2164/7510
dc.identifier.vol240en
dc.language.isoeng
dc.relation.ispartofThe Journal of pathologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjecthippo pathwayen
dc.subjectTAZen
dc.subjectWWTR1en
dc.subjectembryonal rhabdomyosarcomaen
dc.subjectmyoblastsen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subject99477en
dc.subject.lccRen
dc.titleThe Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcomaen
dc.typeJournal articleen

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