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N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness

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dc.contributor.authorMeadows, Allison M
dc.contributor.authorHan, Kim
dc.contributor.authorSingh, Komudi
dc.contributor.authorMurgia, Antonio
dc.contributor.authorMcNally, Ben D
dc.contributor.authorWest, James A
dc.contributor.authorHuffstutler, Rebecca D
dc.contributor.authorPowell-Wiley, Tiffany M
dc.contributor.authorBaumer, Yvonne
dc.contributor.authorGriffin, Julian L
dc.contributor.authorSack, Michael N
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2023-10-25T15:18:00Z
dc.date.available2023-10-25T15:18:00Z
dc.date.issued2023-05-19
dc.descriptionAcknowledgments We thank Drs. Zoe Hall and Sonia Liggi of the University of Cambridge Biochemistry Department for their contributions to metabolomics analysis and data processing. Shahin Hassanzadeh of the Laboratory of Mitochondrial Biology and Metabolism for developing the PBMC RNAseq library.Matthew Rodman of the Laboratory of Mitochondrial Biology and Metabolism for preparing lean/obese samples. Dr. Duck-Yeon Lee of the NHLBI Biochemistry Core for NAGly analysis in cell culture. Special thanks to the National Institutes of Health Oxford-Cambridge Scholars Program and the International Biomedical Research Alliance for their sponsorship and support. Funding: NHLBI Division of Intramural Research (MNS – ZIA-HL005199) and the UK MRC (JLG – MR/P011705/2; UKDRI-5002; MAPUK).en
dc.description.statusPeer revieweden
dc.format.extent19
dc.format.extent4404587
dc.identifier282066303
dc.identifierc77d3828-1bfd-4c5a-af74-ad3b2cd9980c
dc.identifier37128607
dc.identifier85152715868
dc.identifier.citationMeadows, A M, Han, K, Singh, K, Murgia, A, McNally, B D, West, J A, Huffstutler, R D, Powell-Wiley, T M, Baumer, Y, Griffin, J L & Sack, M N 2023, 'N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness', iScience, vol. 26, no. 5, 106578. https://doi.org/10.1016/j.isci.2023.106578en
dc.identifier.doi10.1016/j.isci.2023.106578
dc.identifier.iss5en
dc.identifier.issn2589-0042
dc.identifier.otherPubMedCentral: PMC10148119
dc.identifier.otherORCID: /0000-0003-1336-7744/work/145602734
dc.identifier.urihttps://hdl.handle.net/2164/22019
dc.identifier.vol26en
dc.language.isoeng
dc.relation.ispartofiScienceen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHuman metabolismen
dc.subjectImmunologyen
dc.subjectLipidomicsen
dc.subjectMetabolomicsen
dc.subjectTranscriptomicsen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/P011705/2en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleN-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsivenessen
dc.typeJournal articleen

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