University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

Simple item page
dc.contributor.authorAlvi, Muhammad A.
dc.contributor.authorLoughrey, Maurice B.
dc.contributor.authorDunne, Philip
dc.contributor.authorMcQuaid, Stephen
dc.contributor.authorTurkington, Richard
dc.contributor.authorFuchs, Marc-Aurel
dc.contributor.authorMcGready, Claire
dc.contributor.authorBingham, Victoria
dc.contributor.authorPang, Brendan
dc.contributor.authorMoore, Wendy
dc.contributor.authorMaxwell, Perry
dc.contributor.authorLawler, Mark
dc.contributor.authorJames, Jacqueline A.
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorWilson, Richard H.
dc.contributor.authorSalto-Tellez, Manuel
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2017-06-13T08:00:12Z
dc.date.available2017-06-13T08:00:12Z
dc.date.issued2017-07-11
dc.descriptionWe would like to thank all patients whose samples were used in this study. We are also thankful to the Northern Ireland Biobank and Grampian Biorepository for providing us with tissue blocks and patient data; and Dr HG Coleman (Queen’s University Belfast) for her advice on statistical analyses. This work has been carried out with financial support from Cancer Research UK (grant: C11512/A18067), Experimental Cancer Medicine Centre Network (grant: C36697/A15590 from Cancer Research UK and the NI Health and Social Care Research and Development Division), the Sean Crummey Memorial Fund and the Tom Simms Memorial Fund. The Northern Ireland Biobank is funded by HSC Research and Development Division of the Public Health Agency in Northern Ireland and Cancer Research UK through the Belfast CRUK Centre and the Northern Ireland Experimental Cancer Medicine Centre; additional support was received from Friends of the Cancer Centre. The Northern Ireland Molecular Pathology Laboratory which is responsible for creating resources for the Northern Ireland Biobank has received funding from Cancer Research UK, Friends of the Cancer Centre and Sean Crummey Foundation.en
dc.description.statusPeer revieweden
dc.format.extent7
dc.format.extent1456117
dc.identifier101664644
dc.identifierd541416b-7bea-4331-825c-0bec5ec35755
dc.identifier28595259
dc.identifier85027058602
dc.identifier.citationAlvi, M A, Loughrey, M B, Dunne, P, McQuaid, S, Turkington, R, Fuchs, M-A, McGready, C, Bingham, V, Pang, B, Moore, W, Maxwell, P, Lawler, M, James, J A, Murray, G I, Wilson, R H & Salto-Tellez, M 2017, 'Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies', British Journal of Cancer, vol. 117, no. 2, pp. 203-209. https://doi.org/10.1038/bjc.2017.168en
dc.identifier.doi10.1038/bjc.2017.168
dc.identifier.iss2en
dc.identifier.issn0007-0920
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973572
dc.identifier.urihttp://hdl.handle.net/2164/8800
dc.identifier.vol117en
dc.language.isoeng
dc.relation.ispartofBritish Journal of Canceren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectKITen
dc.subjectgenotypeen
dc.subjectPDL1en
dc.subjectR Medicineen
dc.subjectCancer Research UKen
dc.subjectC11512/A18067en
dc.subjectC36697/A15590en
dc.subject.lccRen
dc.titleMolecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapiesen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
bjc2017168a.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
8.29 KB
Format:
Plain Text
Description:
Download

Collections

All research
Applied Medicine research
University Office research