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Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

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dc.contributor.authorKennedy, Katherine M.
dc.contributor.authorde Goffau, Marcus C.
dc.contributor.authorPerez-Muñoz, Maria Elisa
dc.contributor.authorArrieta, Marie-Claire
dc.contributor.authorBӓckhed, Fredrik
dc.contributor.authorBork, Peer
dc.contributor.authorBraun, Thorsten
dc.contributor.authorBushman, Frederic D
dc.contributor.authorDore, Joel
dc.contributor.authorde Vos, Willem M
dc.contributor.authorEarl, Ashlee M.
dc.contributor.authorEisen, Jonathan A.
dc.contributor.authorElovitz, Michal A.
dc.contributor.authorGanal-Vonarburg, Stephanie C.
dc.contributor.authorGӓnzle, Michael G.
dc.contributor.authorGarrett, Wendy S
dc.contributor.authorHall, Lindsay J.
dc.contributor.authorHornef, Mathias W.
dc.contributor.authorHuttenhower, Curtis
dc.contributor.authorKonnikova, Liza
dc.contributor.authorLebeer, Sarah
dc.contributor.authorMacpherson, Andrew J
dc.contributor.authorMassey, Ruth C.
dc.contributor.authorMcHardy, Alice Carolyn
dc.contributor.authorKoren, Omry
dc.contributor.authorLawley, Trevor D.
dc.contributor.authorLey, Ruth E.
dc.contributor.authorO’Mahony, Liam
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorPamer, Eric G.
dc.contributor.authorParkhill, Julian
dc.contributor.authorRaes, Jeroen
dc.contributor.authorRattei, Thomas
dc.contributor.authorSalonen, Anne
dc.contributor.authorSegal, Eran
dc.contributor.authorSegata, Nicola
dc.contributor.authorShanahan, Fergus
dc.contributor.authorSloboda, Deborah M
dc.contributor.authorSmith, Gordon C.S.
dc.contributor.authorSokol, Harry
dc.contributor.authorSpector, Tim D
dc.contributor.authorSurette, Michael G.
dc.contributor.authorTannock, Gerald W.
dc.contributor.authorWalker, Alan
dc.contributor.authorYassour, Moran
dc.contributor.authorWalter, Jens
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2023-07-24T23:16:56Z
dc.date.available2023-07-24T23:16:56Z
dc.date.embargoedUntil2023-07-25
dc.date.issued2023-01-26
dc.descriptionAcknowledgements. T.B. receives funding from the Deutsche Forschungsgemeinschaft (German Research Foundation No. BR2925 10-1 & PL241 16-1). J.D. acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement ERC-2017-AdG No. 788191 - Homo.symbiosus). W.M.dV. and A.S. are supported by the Academy of Finland (grants 1308255 and 1325103). A.M.E. is funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Department of Health and Human Services, under Grant Number U19AI110818 to the Broad Institute. F.D.B. is funded by AI045008, AI120489, R33HL137063, CA219871, AI139240, and the PennCHOP Microbiome Program. M.A.E. is funded through grants R01HD102318, R01HD098867 and R01NR014784. S.C.G.V. was funded through a Peter Hans Hofschneider Professorship provided by the Stiftung Molekulare Biomedizin. M.G.G. and D.M.S are funded by the Canada Research Chairs Program. L.J.H. is supported by Wellcome Trust Investigator Awards 100974/C/13/Z and 220876/Z/20/Z; the Biotechnology and Biological Sciences Research Council (BBSRC), Institute Strategic Programme Gut Microbes and Health BB/R012490/1, and its constituent projects BBS/E/F/000PR10353 and BBS/E/F/000PR10356. M.W.H. has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101019157). S.L. has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement 852600 Lacto-Be). A.J.M. receives funding from ERCAd HHMM-Neonates and Swiss National Science Sinergia. Work in P.W.O., L.O’M., and J.W. 1162 laboratories is supported by Science Foundation Ireland (SFI) through a Centre award (APC/SFI/12/RC/2273_P2) to APC Microbiome Ireland. J.W. acknowledges support through an SFI Professorship (19/RP/6853) and thanks Victoria McMahon for coordination of this review and Ryan O'Callaghan for encouragement. J.R. acknowledges funding from the Interuniversity Special Research Fund (iBOF) Flanders [FLEXIGUT R-11423], the Rega Institute, VIB and KU Leuven. N.S. receives funding from the European Research Council (ERC-STG project MetaPG1168 716575). F.S. is supported in part by Science Foundation Ireland. G.C.S.S. acknowledges funding from Medical Research Council (UK; MR/K021133/1) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (Women’s Health theme). D.M.S. is funded by the Canadian Institute for Health Research and the Canada Research Chairs Program. A.W.W. receives core funding support from the Scottish Government’s Rural and Environment Science and Analytical Services (RESAS). M.Y. is supported by the Azrieli Faculty Fellowship.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1427558
dc.identifier226202740
dc.identifier3ac52940-6d9f-4ea6-a31a-4d3a7d3b4889
dc.identifier36697862
dc.identifier85146875375
dc.identifier.citationKennedy, K M, de Goffau, M C, Perez-Muñoz, M E, Arrieta, M-C, Bӓckhed, F, Bork, P, Braun, T, Bushman, F D, Dore, J, de Vos, W M, Earl, A M, Eisen, J A, Elovitz, M A, Ganal-Vonarburg, S C, Gӓnzle, M G, Garrett, W S, Hall, L J, Hornef, M W, Huttenhower, C, Konnikova, L, Lebeer, S, Macpherson, A J, Massey, R C, McHardy, A C, Koren, O, Lawley, T D, Ley, R E, O’Mahony, L, O'Toole, P W, Pamer, E G, Parkhill, J, Raes, J, Rattei, T, Salonen, A, Segal, E, Segata, N, Shanahan, F, Sloboda, D M, Smith, G C S, Sokol, H, Spector, T D, Surette, M G, Tannock, G W, Walker, A, Yassour, M & Walter, J 2023, 'Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies', Nature, vol. 613, pp. 639–649 . https://doi.org/10.1038/s41586-022-05546-8en
dc.identifier.doi10.1038/s41586-022-05546-8
dc.identifier.issn0028-0836
dc.identifier.otherORCID: /0000-0001-5099-8495/work/128323558
dc.identifier.urihttps://hdl.handle.net/2164/21298
dc.identifier.vol613en
dc.language.isoeng
dc.relation.ispartofNatureen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectEuropean Research Councilen
dc.subjectERC-2017-AdGen
dc.subject101019157en
dc.subjectWellcome Trusten
dc.subject100974/C/13/Zen
dc.subject220876/Z/20/Zen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/R012490/1en
dc.subjectBBS/E/F/000PR10353en
dc.subjectBBS/E/F/000PR10356en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K021133/1en
dc.subjectRural and Environmental Science and Analytical Services (RESAS)en
dc.subject.lccRen
dc.titleQuestioning the fetal microbiome illustrates pitfalls of low-biomass microbial studiesen
dc.typeJournal articleen

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