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High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

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dc.contributor.authorCao, Huan
dc.contributor.authorAntonopoulos, Aristotelis
dc.contributor.authorHenderson, Sadie
dc.contributor.authorWassall, Heather J.h
dc.contributor.authorBrewin, John
dc.contributor.authorMasson, Alanna
dc.contributor.authorShepherd, Jenna
dc.contributor.authorKonieczny, Gabriela
dc.contributor.authorPatel, Bhinal
dc.contributor.authorWilliams, Maria-Louise
dc.contributor.authorDavie, Adam
dc.contributor.authorForrester, Megan Amy
dc.contributor.authorHall, Lindsay
dc.contributor.authorMinter, Beverley
dc.contributor.authorTampakis, Dimitris
dc.contributor.authorMoss, Michael
dc.contributor.authorLennon, Charlotte
dc.contributor.authorPickford, Wendy
dc.contributor.authorErwig, Lars
dc.contributor.authorRobertson, Beverley
dc.contributor.authorDell, Anne
dc.contributor.authorBrown, Gordon Douglas
dc.contributor.authorWilson, Heather
dc.contributor.authorRees, David C.
dc.contributor.authorHaslam, Stuart M
dc.contributor.authorRowe, J. Alexandra
dc.contributor.authorBarker, Robert
dc.contributor.authorVickers, Mark
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2024-04-11T10:21:02Z
dc.date.available2024-04-11T10:21:02Z
dc.date.issued2020-11-27
dc.descriptionAcknowledgements We are grateful for the assistance provided by both the Microscopy and Histology Core Facility, and the Iain Fraser Cytometry Centre, at the University of Aberdeen. We thank Ann Wheeler and Matt Pearson from Edinburgh Super-Resolution Imaging Consortium for technical support with 3D SIM microscopy. We also thank Janet A. Willment and Bernard Kerscher, supervised by G.D.B., for providing the Fc fusion proteins, Jeanette A. Wagener, supervised by Neil A.R.G. Gow, for providing high purity chitin, Jan Westland for obtaining blood samples and Paul Crocker for useful discussions. Principal funding for this project was provided by Wellcome Trust grant 094847 (R.N.B, L.P.E, M.A.V). In addition, support was provided by Biotechnology and Biological Sciences Research Council grants BBF0083091 (A.D. and S.M.H.) and BBK0161641 (A.D. and S.M.H.), Wellcome Trust grant 082098 (A.D.), Wellcome Trust grants 97377, 102705 (G.D.B) and funding for the MRC Centre for Medical Mycology at the University of Aberdeen MR/N006364/1 (G.D.B).en
dc.description.statusNon peer revieweden
dc.format.extent11341132
dc.identifier183819508
dc.identifier7b6c7975-1e06-4e1f-ad74-3b0fa37f83a0
dc.identifier.citationCao, H, Antonopoulos, A, Henderson, S, Wassall, H J H, Brewin, J, Masson, A, Shepherd, J, Konieczny, G, Patel, B, Williams, M-L, Davie, A, Forrester, M A, Hall, L, Minter, B, Tampakis, D, Moss, M, Lennon, C, Pickford, W, Erwig, L, Robertson, B, Dell, A, Brown, G D, Wilson, H, Rees, D C, Haslam, S M, Rowe, J A, Barker, R & Vickers, M 2020, 'High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria', bioRxiv. https://doi.org/10.1101/2020.11.26.399402en
dc.identifier.doi10.1101/2020.11.26.399402
dc.identifier.otherORCID: /0000-0002-3154-1040/work/86449712
dc.identifier.otherORCID: /0000-0002-1407-7274/work/91891238
dc.identifier.urihttps://hdl.handle.net/2164/23221
dc.language.isoeng
dc.relation.ispartofbioRxiven
dc.subjectOutside of REF 2029 publication perioden
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectQR180 Immunologyen
dc.subject.lccRen
dc.subject.lccQR180en
dc.titleHigh mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malariaen
dc.typeJournal articleen

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