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MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation

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dc.contributor.authorSwahari, Vijay
dc.contributor.authorNakamura, Ayumi
dc.contributor.authorHollville, Emilie
dc.contributor.authorStroud, Hume
dc.contributor.authorSimon, Jeremy M.
dc.contributor.authorPtacek, Travis S.
dc.contributor.authorBeck, Matthew V.
dc.contributor.authorFlowers, Cornelius
dc.contributor.authorGuo, Jiami
dc.contributor.authorPlestant, Charlotte
dc.contributor.authorLiang, Jie
dc.contributor.authorKurtz, C. Lisa
dc.contributor.authorKanke, Matt
dc.contributor.authorHammond, Scott M.
dc.contributor.authorHe, You Wen
dc.contributor.authorAnton, E. S.
dc.contributor.authorSethupathy, Praveen
dc.contributor.authorMoy, Sheryl S.
dc.contributor.authorGreenberg, Michael E.
dc.contributor.authorDeshmukh, Mohanish
dc.date.accessioned2023-06-09T11:10:01Z
dc.date.available2023-06-09T11:10:01Z
dc.date.issued2021-04-06
dc.descriptionAcknowledgments We thank the members of the Deshmukh Lab for critical review of this manuscript. We also acknowledge Dr. Natallia Riddick, Viktoriya Nikolova, and Dr. Kara Agster at the UNC Mouse Behavioral Phenotyping Laboratory, for their technical assistance. We thank Mervi Eeva, Ying Li, and Bentley Midkiff at the UNC Translational Pathology Laboratory for expert technical assistance. We also appreciate the technical assistance provided by Janice Weaver and Carolyn Suitt at the UNC Animal Histopathology and the Center for Gastrointestinal Biology and Disease (CGIBD), respectively. The graphical abstract was created partly with BioRender.com. This work was supported by NIH, United States (GM118331 and AG055304 to M.D.). H.S. is a Howard Hughes Medical Institute Fellow of the Damon Runyon Cancer Research Foundation, United States (DRG-2194-14). J.M.S. and T.S.P. were supported by The Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD079124) and NINDS (P30NS045892) of United States. The UNC Mouse Behavioral Phenotyping Laboratory is supported by a grant from the National Institute of Child Health and Human Development (NICHD), United States (U54-HD079124). The UNC Translational Pathology Laboratory is supported in part by grants from the NCI (5P30CA016086-42), NIH (U54-CA156733), NIEHS (5 P30 ES010126-17), UCRF, and NCBT (2015-IDG-1007) of United States. Author contributions V.S., A.N., and E.H. conducted most of the experiments with help as described here. H.S. and M.E.G. performed the whole-genome bisulfite sequencing and its analyses. J.M.S. and T.S.P. analyzed all RNA-seq data. C.L.K., M.K., P.S., and S.M.H. performed small RNA-seq and miRHub analysis. C.P., J.G., and E.A. helped with imaging and analysis of immunohistochemical stains. C.F. and M.B. helped manage the mouse colony. J.L. and Y.-W.H. generated the miR-29-floxed mice. S.M. conducted and analyzed many of the neurobehavioral assessments. V.S., M.E.G., and M.D. outlined the project. M.D. supervised the project. V.S., A.N., E.H., and M.D. produced the final version of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent4504350
dc.identifier219148793
dc.identifier41204a9c-3830-41dd-a9d4-b9e09acc8a46
dc.identifier85103714487
dc.identifier33826889
dc.identifier.citationSwahari, V, Nakamura, A, Hollville, E, Stroud, H, Simon, J M, Ptacek, T S, Beck, M V, Flowers, C, Guo, J, Plestant, C, Liang, J, Kurtz, C L, Kanke, M, Hammond, S M, He, Y W, Anton, E S, Sethupathy, P, Moy, S S, Greenberg, M E & Deshmukh, M 2021, 'MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation', Cell Reports, vol. 35, no. 1, 108946. https://doi.org/10.1016/j.celrep.2021.108946en
dc.identifier.doi10.1016/j.celrep.2021.108946
dc.identifier.issn2211-1247
dc.identifier.otherORCID: /0000-0001-5711-8542/work/120621962
dc.identifier.urihttps://hdl.handle.net/2164/20815
dc.identifier.urlhttps://www.scopus.com/pages/publications/85103714487en
dc.language.isoeng
dc.relation.ispartofCell Reportsen
dc.subjectNo substantive link to the University of Aberdeenen
dc.subjectautismen
dc.subjectCH methylationen
dc.subjectDNMT3Aen
dc.subjectepilepsyen
dc.subjectMeCP2en
dc.subjectmiR-29en
dc.subjectmiRNAen
dc.subjectneurodevelopmental disordersen
dc.subjectnon-CG methylationen
dc.subjectseizuresen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectQH426 Geneticsen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectDevelopmental Neuroscienceen
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.subject.lccQH426en
dc.titleMicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylationen
dc.typeJournal articleen

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