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Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB1R) "Cis-On" Agonist.

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dc.contributor.authorRodríguez-Soacha, Diego A
dc.contributor.authorSteinmüller, Sophie A M
dc.contributor.authorIşbilir, Ali
dc.contributor.authorFender, Julia
dc.contributor.authorDeventer, Marie H
dc.contributor.authorRamírez, Yesid A
dc.contributor.authorTutov, Anna
dc.contributor.authorSotriffer, Christoph
dc.contributor.authorStove, Christophe P
dc.contributor.authorLorenz, Kristina
dc.contributor.authorLohse, Martin J
dc.contributor.authorHislop, James N
dc.contributor.authorDecker, Michael
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2023-07-25T23:08:35Z
dc.date.available2023-07-25T23:08:35Z
dc.date.embargoedUntil2023-07-26
dc.date.issued2022-08-17
dc.descriptionFunding This project was financially supported by the German Research Foundation (Deutsche Forschungsgemeinschaft under DFG DE1546/10-1) and a Ph.D. scholarship for D.A.R.-S. by the German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD). Y.A.R. was granted a scholarship by the DAAD program “Research stays for university academics and scientists”. A.T. and J.F. were supported by the International Doctoral Program funded within the framework of the Elite Network of Bavaria (grant no. K-BM2013-247). J.N.H. financing support was given by NHS Grampian. The research visit of S.A.M.S. in J.N.H.’s laboratory was also funded by the Elite Network of Bavaria (grant no. KBM-2013-247). M.H.D. was supported by the Research Foundation Flanders (FWO, grant no. 1S54521N). M.J.L. was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, SFB1423, TPC03). Notes The authors declare no competing financial interest. ACKNOWLEDGMENTS Special thanks go to Dr. Rangan Maitra and RTI International for providing the Gαq16 coupled hCB1 and hCB2 CHO-K1 cell lines. The authors thank Nadine Yurdagül-Hemmrich for excellent technical support.en
dc.description.statusPeer revieweden
dc.format.extent26
dc.format.extent2064348
dc.identifier218776703
dc.identifier85aad7a3-0618-4490-9b80-93fbbb2622c1
dc.identifier35881914
dc.identifier85135901397
dc.identifier.citationRodríguez-Soacha, D A, Steinmüller, S A M, Işbilir, A, Fender, J, Deventer, M H, Ramírez, Y A, Tutov, A, Sotriffer, C, Stove, C P, Lorenz, K, Lohse, M J, Hislop, J N & Decker, M 2022, 'Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB 1 R) "Cis-On" Agonist.', ACS Chemical Neuroscience, vol. 13, no. 16, pp. 2410–2435. https://doi.org/10.1021/acschemneuro.2c00160en
dc.identifier.doi10.1021/acschemneuro.2c00160
dc.identifier.iss16en
dc.identifier.issn1948-7193
dc.identifier.urihttps://hdl.handle.net/2164/21309
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85135901397&partnerID=8YFLogxKen
dc.identifier.vol13en
dc.language.isoeng
dc.relation.ispartofACS Chemical Neuroscienceen
dc.subjectphotopharmacologyen
dc.subjectCB1 agonisten
dc.subjectG-protein-coupled receptoren
dc.subjectdiazocineen
dc.subjectphotorimonabanten
dc.subjectoptical controlen
dc.subjectR Medicine (General)en
dc.subjectSupplementary Informationen
dc.subject.lccR1en
dc.titleDevelopment of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB1R) "Cis-On" Agonist.en
dc.typeJournal articleen

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