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The effects of caloric restriction on adipose tissue and metabolic health are sex-and age-dependent.

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dc.contributor.authorSuchacki, Karla J.
dc.contributor.authorThomas, Ben J.
dc.contributor.authorIkushima, Yoshiko M.
dc.contributor.authorChen, Kuan Chan
dc.contributor.authorFyfe, Claire
dc.contributor.authorTavares, Adriana A.S.
dc.contributor.authorSulston, Richard J.
dc.contributor.authorLovdel, Andrea
dc.contributor.authorWoodward, Holly J.
dc.contributor.authorHan, Xuan
dc.contributor.authorMattiucci, Domenico
dc.contributor.authorBrain, Eleanor J.
dc.contributor.authorAlcaide-Corral, Carlos J.
dc.contributor.authorKobayashi, Hiroshi
dc.contributor.authorGray, Gillian A.
dc.contributor.authorWhitfield, Phillip D.
dc.contributor.authorStimson, Roland H.
dc.contributor.authorMorton, Nicholas M.
dc.contributor.authorJohnstone, Alexandra M.
dc.contributor.authorCawthorn, William P.
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Human Nutrition Unit (HNU)en
dc.date.accessioned2023-07-13T14:55:01Z
dc.date.available2023-07-13T14:55:01Z
dc.date.issued2023-04-25
dc.descriptionThis work was supported by grants from the Medical Research Council (MR/M021394/1 to W.P.C.), the British Heart Foundation (BHF) (RG/16/10/32375 and FS/19/34/34354 to A.A.S.T.; 4-year BHF PhD Studentship to B.J.T. and R.J.S.), the Takeda Science Foundation (Fellowship for Young Japanese MDs & PhDs Studying Abroad, to Y.M.I.), the Japan Society for the Promotion of Science (JSPS Overseas Research Fellowship, to Y.M.I.), the Japan Foundation for Applied Enzymology (to Y.M.I.), the University of Edinburgh (Chancellor’s Fellowship to W.P.C.; PhD Studentship to A.L.), the Carnegie Trust (RIG007416 to W.P.C.), the Wellcome Trust (Technology Development Award 221295/Z/20/Z to A.A.S.T.; Multi-user equipment grant 223818/Z/21/Z for the Promethion system), the Chief Scientist Office of the Scottish Government (SCAF/17/02 to R.H.S.), KAKENHI grants from MEXT/JSPS (21K08431 to H.K.), and a grant from the National Center for Global Health and Medicine (20A1010 to H.K.). C.F. and A.M.J. gratefully acknowledge financial support from the Scottish Government as part of the RESAS Strategic Research Programme at the Rowett Institute, University of Aberdeen. We thank Ami Onishi for assistance with indirect calorimetry studies using the Promethion system, and the BHF for supporting Ami Onishi’s salary through the Centre for Research Excellence Award III (RE/18/5/34216). The BHF also provided funding towards establishment of the Edinburgh Preclinical PET/CT laboratory (RE/13/3/30183) and support of the 2018 Very Important Project (VIP) PET prize, for which we are grateful. Finally, we thank Dr Matthew Bennett (University of Edinburgh) for advice analysing RNA-seq data; Prof Robert Semple (University of Edinburgh) and Prof Ormond MacDougald (University of Michigan) for helpful advice to interpret our findings; Stefanie Fung (University of Edinburgh) for assistance isolating RNA for RNA-seq; Dr Hai-Bin Ruan (University of Minnesota Medical School) and Dr Eleonora Pagano (Pontifical Catholic University of Argentina) for kindly providing a full text of Ballor and Poehlman’s 1994 study (78), and all staff at Edinburgh Bioresearch & Veterinary Services for their superb technical support. Finally, this manuscript was written entirely by the authors and without any use of large language models.en
dc.description.statusPeer revieweden
dc.format.extent41
dc.format.extent8021632
dc.identifier263775282
dc.identifierdd48d477-c97d-45bc-ac98-d24671b899dc
dc.identifier85156227925
dc.identifier37096321
dc.identifier.citationSuchacki, K J, Thomas, B J, Ikushima, Y M, Chen, K C, Fyfe, C, Tavares, A A S, Sulston, R J, Lovdel, A, Woodward, H J, Han, X, Mattiucci, D, Brain, E J, Alcaide-Corral, C J, Kobayashi, H, Gray, G A, Whitfield, P D, Stimson, R H, Morton, N M, Johnstone, A M & Cawthorn, W P 2023, 'The effects of caloric restriction on adipose tissue and metabolic health are sex-and age-dependent.', eLife, vol. 12, e88080. https://doi.org/10.7554/eLife.88080en
dc.identifier.doi10.7554/eLife.88080
dc.identifier.issn2050-084X
dc.identifier.otherORCID: /0000-0001-6521-2651/work/138945230
dc.identifier.otherORCID: /0000-0002-5484-292X/work/138945346
dc.identifier.urihttps://hdl.handle.net/2164/21208
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85156227925&partnerID=8YFLogxKen
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofeLifeen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectadipose tissueen
dc.subjectageingen
dc.subjectcaloric restrictionen
dc.subjectenergy balanceen
dc.subjectglucose homeostasisen
dc.subjectinsulin sensitivityen
dc.subjectlipidomicsen
dc.subjectliver metabolismen
dc.subjectPET/CTen
dc.subjectSex differencesen
dc.subjectR Medicineen
dc.subjectGeneral Neuroscienceen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Immunology and Microbiologyen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleThe effects of caloric restriction on adipose tissue and metabolic health are sex-and age-dependent.en
dc.typeJournal articleen

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